Clinical Practice Guidelines for Clostridium difficile Infection in Adults: 2010 Update by the Society for Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA)

Infection Control and Hospital Epidemiology - Tập 31 Số 05 - Trang 431-455 - 2010
Stuart H. Cohen1, Dale N. Gerding2, Stuart Johnson2, Ciarán P. Kelly3, Vivian G. Loo4, L. Clifford McDonald5, Jean‐Louis Pépin6, Mark H. Wilcox7
1Department of Internal Medicine, Division of Infectious and Immunologic Diseases, University of California Davis Medical Center, Sacramento, California
2Research Service, Edward Hines Jr. Veterans Affairs Hospital, and Infectious Disease Division, Department of Medicine, Loyola University Chicago Stritch School of Medicine, Maywood, Illinois
3Division of Gastroenterology Beth Israel Deaconess Medical Center, Boston, Massachusetts
4Department of Microbiology, McGill University Health Center, Montreal, Quebec, Canada
5Division of Healthcare Quality Promotion, National Center for Preparedness, Detection, and Control of Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia
6Department of Microbiology and Infectious Diseases, University of Sherbrooke, Quebec, Canada
7Department of Microbiology, Leeds Teaching Hospitals National Health Service Trust and Institute of Molecular and Cellular Biology, University of Leeds, Leeds, United Kingdom

Tóm tắt

Since publication of the Society for Healthcare Epidemiology of America position paper onClostridium difficileinfection in 1995, significant changes have occurred in the epidemiology and treatment of this infection.C. difficileremains the most important cause of healthcare-associated diarrhea and is increasingly important as a community pathogen. A more virulent strain ofC. difficilehas been identified and has been responsible for more-severe cases of disease worldwide. Data reporting the decreased effectiveness of metronidazole in the treatment of severe disease have been published. Despite the increasing quantity of data available, areas of controversy still exist. This guideline updates recommendations regarding epidemiology, diagnosis, treatment, and infection control and environmental management.

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