Clinical Aspects and Pathophysiology of Inflammatory Bowel Disease

Clinical Microbiology Reviews - Tập 15 Số 1 - Trang 79-94 - 2002
Barbara A. Hendrickson1,2,3, Ranjana Gokhale4,1,2,5, Judy H. Cho6,1,2
1Department of Pediatrics and the The Martin Boyer Laboratories and Section of Gastroenterology, Department of Medicine, University of Chicago, Chicago, Illinois 60637
2Gastroenterology.
3Section of Infectious Diseases, Department of Pediatrics and the The Martin Boyer Laboratories, University of Chicago, Chicago, Illinois 60637, USA.
42Gastroenterology
5Section of Infectious Diseases
63Department of Pediatrics and the The Martin Boyer Laboratories and Section of Gastroenterology, Department of Medicine, University of Chicago, Chicago, Illinois 60637

Tóm tắt

SUMMARYThe chronic inflammatory bowel diseases (IBD), Crohn's disease and ulcerative colitis, are recognized as important causes of gastrointestinal disease in children and adults. In this review we delineate the clinical manifestations and diagnostic features of IBD. In addition, we summarize important recent advances in our understanding of the immune mediators of intestinal inflammation. This information has led to new therapeutic approaches in IBD. Further, we discuss the considerable data that point to the significance of genetic factors in the development of IBD and the genetic loci which have been implicated through genomewide searches. The commensal bacterial flora also appears to be a critical element, particularly in regards to Crohn's disease, although the precise role of the bacteria in the disease manifestations remains unclear. Current investigations promise to yield fresh insights in these areas.

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Clinical Microbiology Reviews

Tập 15 Số 1

79-94

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