Cleavage of amyloid precursor protein elicited by chronic cerebral hypoperfusion

Baiden–Amissah, 1998, Expression of amyloid precursor protein (beta-APP) in the neonatal brain following hypoxic ischemic injury, Neuropathol Appl Neurobiol, 24, 346, 10.1046/j.1365-2990.1998.00141.x Barrow, 1988, Unruptured cerebral arteriovenous malformations presenting with intracranial hypertension, Neurosurgery, 23, 484, 10.1227/00006123-198810000-00014 Bennett, 1998, Chronic cerebral hypoperfusion elicits neuronal apoptosis and behavioral impairment, Neuroreport, 9, 161, 10.1097/00001756-199801050-00033 Davidson, 2000, Chronic cerbrohypoperfusion, Brain Res, 859, 96, 10.1016/S0006-8993(00)01937-5 de la Torre, 1993, Brain blood flow restoration ‘rescues’ chronically damaged rat CA1 neurons, Brain Res, 623, 6, 10.1016/0006-8993(93)90003-6 de la Torre, 1992, Chronic cerebrovascular insufficiency induces dementia-like deficits in aged rats, Brain Res, 582, 186, 10.1016/0006-8993(92)90132-S de la Torre, 1993, Can disturbed brain microcirculation cause Alzheimer’s disease?, Neurol Res, 15, 146, 10.1080/01616412.1993.11740127 Kalaria, 1996, Cerebral vessels in ageing and Alzheimer’s Disease, Pharmacol Ther, 72, 193, 10.1016/S0163-7258(96)00116-7 Kalaria, 1993, The amyloid precursor protein in ischemic brain injury and chronic hypoperfusion, Ann NY Acad Sci, 695, 190, 10.1111/j.1749-6632.1993.tb23050.x Kalaria, 1993, Accumulation of beta-amyloid at sites of ischemic injury in rat brain, Neuroreport, 4, 211, 10.1097/00001756-199302000-00025 Kalaria, 1995, Differential degeneration of the cerebral microvasculature in Alzheimer’s disease, Neuroreport, 6, 477, 10.1097/00001756-199502000-00018 Lin, 1999, Progressive parenchymal deposition of beta-amyloid protein in rat brain following global cerebral ischemia, Acta Neuropathol, 97, 359, 10.1007/s004010050999 Nishimura, 1998, Degeneration in vivo of rat hippocampal neurons by wild-type Alzheimer amyloid precursor protein overexpressed by adenovirus-mediated gene transfer, J Neurosci, 18, 2387, 10.1523/JNEUROSCI.18-07-02387.1998 Otori, 1997, Measurement of regional cerebral blood flow and glucose utilization in rat brain under chronic hypoperfusion conditions following bilateral carotid artery occlusion. Analyzed by autoradiographical methods, Nippon Ika Diagaku Zasshi, 64, 428, 10.1272/jnms1923.64.428 Pappas, 1996, Chronic reduction of cerebral blood flow in the adult rat, Brain Res, 708, 50, 10.1016/0006-8993(95)01267-2 Plaschke, 1998, Effect of propentofylline on hippocampal brain energy state and amyloid precursor protein concentration in a rat model of cerebral hypoperfusion, J Neural Transm, 105, 1065, 10.1007/s007020050112 Schmidt–Kastner, 1997, Subtle neuronal death in striatum after short forebrain ischemia in rats detected by in situ end-labeling for DNA damage, Stroke, 28, 163, 10.1161/01.STR.28.1.163 Sekhon, 1997, Chronic cerebral hypoperfusion, Neurosurgery, 40, 548 Tsuchiya, 1992, Cerebral blood flow and histopathological changes floowing bilateral carotid artery ligation in Wistar rats, Exp Brain Res, 89, 87, 10.1007/BF00229004 Uehara, 1999, A new model of white matter injury in neonatal rats with bilateral carotid artery occlusion, Brain Res, 837, 213, 10.1016/S0006-8993(99)01675-3 Uetsuki, 1999, Activation of neuronal caspase-3 by intracellular accumulation of wild-type Alzheimer amyloid precursor protein, J Neurosci, 19, 6955, 10.1523/JNEUROSCI.19-16-06955.1999 Yokaota, 1996, Cytotxic fragment of amyloid precursor protein accumulates in hippocampus after global forebrain ischemia, Cereb Blood Flow Metab, 16, 1219, 10.1097/00004647-199611000-00016 Yoshikawa, 1992, Degeneration in vitro of post-mitotic neurons overexpressing the Alzheimer amyloid protein precursor, Nature, 359, 64, 10.1038/359064a0 Zhang, 1997, Increased susceptibility to ischemic brain damage in transgenic mice overexpressing the amyloid precursor protein, J Neurosci, 17, 7655, 10.1523/JNEUROSCI.17-20-07655.1997