Cleavage of BID by Caspase 8 Mediates the Mitochondrial Damage in the Fas Pathway of Apoptosis

Cell - Tập 94 Số 4 - Trang 491-501 - 1998
Honglin Li1, Hong Zhu1, Chi-jie Xu1, Junying Yuan1
1Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.

Tóm tắt

Từ khóa


Tài liệu tham khảo

Boldin, 1996, Involvement of MACH, a novel MORT1/FADD-interacting protease, in Fas/APO-1- and TNF receptor-induced cell death, Cell, 85, 803, 10.1016/S0092-8674(00)81265-9

Bossy-Wetzel, 1998, Mitochondrial cytochrome C release in apoptosis occurs upstream of DEVD-specific caspase activation and independent of mitochondrial transmembrane depolarization, EMBO J., 17, 37, 10.1093/emboj/17.1.37

Cheng, 1997, Conversion of Bcl-2 to a Bax-like death effector by caspases, Science, 278, 1966, 10.1126/science.278.5345.1966

Chittenden, 1995, A conserved domain in Bak, distinct from BH1 and BH2, mediates cell death and protein binding functions, EMBO J., 14, 5589, 10.1002/j.1460-2075.1995.tb00246.x

Clem, 1998, Modulation of cell death by Bcl-xL through caspase interaction, Proc. Natl. Acad. Sci. USA, 95, 554, 10.1073/pnas.95.2.554

Conradt, 1998, The C. elegans protein EGL-1 is required for programmed cell death and interacts with the Bcl-2-like protein CED-9, Cell, 93, 519, 10.1016/S0092-8674(00)81182-4

Cosulich, 1997, Regulation of apoptosis by BH3 domains in a cell-free system, Curr. Biol., 7, 913, 10.1016/S0960-9822(06)00410-6

Cryns, 1998, Proteases to die for, Genes Dev., 12, 1551, 10.1101/gad.12.11.1551

Fernandes-Alnemri, 1996, In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains, Proc. Natl. Acad. Sci. USA, 93, 7464, 10.1073/pnas.93.15.7464

Hsu, 1997, Nonionic detergents induces dimerization among members of the Bcl-2 family, J. Biol. Chem., 272, 13829, 10.1074/jbc.272.21.13829

Hu, 1998, Bcl-xL interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation, Proc. Natl. Acad. Sci. USA, 95, 4386, 10.1073/pnas.95.8.4386

Huang, 1998, The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4, EMBO J., 17, 1029, 10.1093/emboj/17.4.1029

Kelekar, 1997, Bad is a BH3 domain–containing protein that forms an inactivating dimer with Bcl-XL, Mol. Cell. Biol., 17, 7040, 10.1128/MCB.17.12.7040

Kischkel, 1995, Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins form a death-inducing signaling complex (DISC) with the receptor, EMBO J., 14, 5579, 10.1002/j.1460-2075.1995.tb00245.x

Kluck, 1997, The release of cytochrome c from mitochondria, Science, 275, 1132, 10.1126/science.275.5303.1132

Knudson, 1997, Bcl-2 and Bax function independently to regulate cell death, Nat. Genet., 16, 358, 10.1038/ng0897-358

Li, 1997, Cell-specific induction of apoptosis by microinjection of cytochrome c. Bcl-xL has activity independent of cytochrome c release, J. Biol. Chem., 272, 30299, 10.1074/jbc.272.48.30299

Li, 1997, Activation of caspase-2 in apoptosis, J. Biol. Chem., 272, 21010, 10.1074/jbc.272.34.21010

Li, 1997, Cytochrome C and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade, Cell, 91, 479, 10.1016/S0092-8674(00)80434-1

Liu, 1996, Induction of apoptotic program in cell free extracts, Cell, 86, 147, 10.1016/S0092-8674(00)80085-9

Lustig, 1997, Small pool expression screening, Methods Enzymol., 283, 83, 10.1016/S0076-6879(97)83009-1

Medema, 1998, Bcl-xL acts downstream of caspase-8 activation by the CD95 death- inducing signaling complex, J. Biol. Chem., 273, 3388, 10.1074/jbc.273.6.3388

Merry, 1997, Bcl-2 gene family in the nervous system, Annu. Rev. Neurosci., 20, 245, 10.1146/annurev.neuro.20.1.245

Miura, 1993, Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3, Cell, 75, 653, 10.1016/0092-8674(93)90486-A

Muzio, 1996, FLICE, a novel FADD-homologous ICE/CED-3-like protease, is recruited to the CD95 (Fas/APO-1) death-inducing signaling complex, Cell, 85, 817, 10.1016/S0092-8674(00)81266-0

Oltvai, 1994, Checkpoints of dueling dimers foil death wishes, Cell, 79, 189, 10.1016/0092-8674(94)90188-0

Pan, 1998, Caspase-9, Bcl-xL, and Apaf-1 form a ternary complex, J. Biol. Chem., 273, 5916, 10.1074/jbc.273.10.5841

Salvesen, 1997, Caspases, Cell, 91, 443, 10.1016/S0092-8674(00)80430-4

Scaffidi, 1998, Two CD95 (APO-1/Fas) signaling pathways, EMBO J., 17, 1675, 10.1093/emboj/17.6.1675

Shimizu, 1996, Bcl-2 blocks loss of mitochondrial membrane potential while ICE inhibitors act a different step during inhibition of death induced by respiratory chain inhibitors, Oncogene, 13, 21

Shimizu, 1998, Bcl-2 prevents apoptotic mitochondrial dysfunction by regulating proton flux, Proc. Natl. Acad. Sci. USA, 95, 1455, 10.1073/pnas.95.4.1455

Srinivasan, 1998, Bcl-xL functions downstream of caspase-8 to inhibit Fas- and tumor necrosis factor receptor 1-induced apoptosis of MCF7 breast carcinoma cells, J. Biol. Chem., 273, 4523, 10.1074/jbc.273.8.4523

Susin, 1996, Bcl-2 inhibits the mitochondrial release of an apoptogenic protease, J. Exp. Med., 184, 1331, 10.1084/jem.184.4.1331

Thornberry, 1997, A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis, J. Biol. Chem., 272, 17907, 10.1074/jbc.272.29.17907

Vander Heiden, 1997, Bcl-xL regulates the membrane potential and volume homeostasis of mitochondria, Cell, 91, 627, 10.1016/S0092-8674(00)80450-X

Wang, 1996, BID, Genes Dev., 10, 2859, 10.1101/gad.10.22.2859

Wolter, 1997, Movement of Bax from the cytosol to mitochondria during apoptosis, J. Cell. Biol., 139, 1281, 10.1083/jcb.139.5.1281

Xue, 1997, Caenorhabditis elegans CED-9 protein is a bifunctional cell-death inhibitor, Nature, 390, 305, 10.1038/36889

Yang, 1995, Bad, a heterodimeric partner for Bcl-xl and Bcl-2, displaces Bax and promotes cell death, Cell, 80, 285, 10.1016/0092-8674(95)90411-5

Yang, 1997, Prevention of apoptosis by Bcl-2, Science, 275, 1129, 10.1126/science.275.5303.1129

Zha, 1996, Serine phosphorylation of death agonist BAD in response to survival factor results in binding to 14–3–3 not BCL-XL, Cell, 87, 619, 10.1016/S0092-8674(00)81382-3

Zhou, 1997, Target protease specificity of the viral serpin CrmA. Analysis of five caspases, J. Biol. Chem., 272, 7797, 10.1074/jbc.272.12.7797

Zou, 1997, Apaf-1, a human protein homologous to C. elegans CED-4, participates in cytochrome c-dependent activation of caspase-3, Cell, 90, 405, 10.1016/S0092-8674(00)80501-2