Cleavage activation and functional comparison of Manduca sexta serine protease homologs SPH1a, SPH1b, SPH4, and SPH101 in conjunction with SPH2

Cao, 2015, Sequence conservation, phylogenetic relationships, and expression profiles of nondigestive serine proteases and serine protease homologs in Manduca sexta, Insect. Biochem. Mol. Biol., 62, 51, 10.1016/j.ibmb.2014.10.006 Cao, 2015, Integrated modeling of protein-coding genes in the Manduca sexta genome using RNA-Seq data from the biochemical model insect, Insect Biochem. Mol. Biol., 62, 2, 10.1016/j.ibmb.2015.01.007 Cao, 2020, Changes in composition and levels of hemolymph proteins during metamorphosis of Manduca sexta, Insect Biochem. Mol. Biol., 127, 103489, 10.1016/j.ibmb.2020.103489 Cao, 2017, Serine protease-related proteins in the malaria mosquito, Anopheles gambiae, Insect Biochem. Mol. Biol., 88, 48, 10.1016/j.ibmb.2017.07.008 Cao, 2018, Building a platform for predicting functions of serine protease-related proteins in Drosophila melanogaster and other insects, Insect Biochem. Mol. Biol., 103, 53, 10.1016/j.ibmb.2018.10.006 Cox, 2008, MaxQuant enables high peptide identification rates, individualized p.p.b.-range mass accuracies and proteome-wide protein quantification, Nat. Biotechnol., 26, 1367, 10.1038/nbt.1511 Dunn, 1983, Fate of bacteria injected into naïve and immunized larvae of the tobacco hornworm, Manduca sexta, J. Invertebr. Pathol., 41, 77, 10.1016/0022-2011(83)90238-0 Edgar, 2004, MUSCLE: multiple sequence alignment with high accuracy and high throughput, Nucleic Acids Res., 32, 1792, 10.1093/nar/gkh340 El Moussawi, 2019, The mosquito melanization response requires hierarchical activation of non-catalytic clip domain serine protease homologs, PLoS Pathog., 15, 10.1371/journal.ppat.1008194 Gupta, 2005, Manduca sexta prophenoloxidase (proPO) activation requires proPO-activating proteinase (PAP) and serine proteinase homologs (SPHs) simultaneously, Insect Biochem. Mol. Biol., 35, 241, 10.1016/j.ibmb.2004.12.003 He, 2016, Changes in the plasma proteome of Manduca sexta larvae in relation to the transcriptome variations after an immune challenge: evidence for high molecular weight immune complex formation, Mol. Cell. Proteomics, 15, 1176, 10.1074/mcp.M115.054296 Jiang, 2010, Immunity in lepidopteran insects, Adv. Exp. Med. Biol., 708, 181, 10.1007/978-1-4419-8059-5_10 Jiang, 2005, Molecular identification of a bevy of serine proteinases in Manduca sexta hemolymph, Insect Biochem. Mol. Biol., 35, 931, 10.1016/j.ibmb.2005.03.009 Jiang, 1997, Subunit composition of prophenoloxidase from Manduca sexta: molecular cloning of subunit proPO-p1, Insect Biochem. Mol. Biol., 27, 835, 10.1016/S0965-1748(97)00066-0 Jiang, 1998, Pro-phenoloxidase activating proteinase from an insect, Manduca sexta: a bacteria-inducible protein similar to Drosophila easter, Proc. Natl. Acad. Sci. U.S.A., 95, 12220, 10.1073/pnas.95.21.12220 Jiang, 2003, Prophenoloxidase-activating proteinase-2 from hemolymph of Manduca sexta: a bacteria-inducible serine proteinase containing two clip domains, J. Biol. Chem., 278, 3552, 10.1074/jbc.M205743200 Jiang, 2003, Prophenoloxidase-activating proteinase-3 from Manduca sexta hemolymph: a clip-domain serine proteinase regulated by serpin-1J and serine proteinase homologs, Insect Biochem. Mol. Biol., 33, 1049, 10.1016/S0965-1748(03)00123-1 Kan, 2008, Molecular control of phenoloxidase-induced melanin synthesis in an insect, J. Biol. Chem., 283, 25316, 10.1074/jbc.M804364200 Kanost, 2016, Multifaceted biological insights from a draft genome sequence of the tobacco hornworm moth, Manduca sexta, Insect Biochem. Mol. Biol., 76, 118, 10.1016/j.ibmb.2016.07.005 Kanost, 2015, Clip-domain serine proteases as immune factors in insect hemolymph, Curr. Opin. Insect Sci., 11, 47, 10.1016/j.cois.2015.09.003 Kim, 2002, A new easter-type serine protease cleaves a masquerade-like protein during prophenoloxidase activation in Holotrichia diomphalia larvae, J. Biol. Chem., 277, 39999, 10.1074/jbc.M205508200 Kumar, 2018, MEGA X: molecular evolutionary genetics analysis across computing platforms, Mol. Biol. Evol., 35, 1547, 10.1093/molbev/msy096 Kwon, 2000, A masquerade-like serine proteinase homologue is necessary for phenoloxidase activity in the coleopteran insect, Holotrichia diomphalia larvae, Eur. J. Biochem., 267, 6188, 10.1046/j.1432-1327.2000.01695.x Lee, 2002, A zymogen form of masquerade-like serine proteinase homologue is cleaved during pro-phenoloxidase activation by Ca2+ in coleopteran and Tenebrio molitor larvae, Eur. J. Biochem., 269, 4375, 10.1046/j.1432-1033.2002.03155.x Lee, 1998, In vitro activation of pro-phenol-oxidase by two kinds of pro-phenol-oxidase-activating factors isolated from hemolymph of coleopteran, Holotrichia diomphalia larvae, Eur. J. Biochem., 254, 50, 10.1046/j.1432-1327.1998.2540050.x Lu, 2008, Expression of Manduca sexta serine proteinase homolog precursors in insect cells and their proteolytic activation, Insect Biochem. Mol. Biol., 38, 89, 10.1016/j.ibmb.2007.09.011 Miao, 2020, Digestion-related proteins in the tobacco hornworm, Manduca sexta, Insect Biochem. Mol. Biol., 126, 103457, 10.1016/j.ibmb.2020.103457 Murugasu-Oei, 1996, Mutations in masquerade, a novel serine-protease-like molecule, affect axonal guidance and taste behavior in Drosophila, Mech. Dev., 57, 91, 10.1016/0925-4773(96)00537-0 Nakhleh, 2017, The serine protease homolog CLIPA14 modulates the intensity of the immune response in the mosquito Anopheles gambiae, J. Biol. Chem., 292, 18217, 10.1074/jbc.M117.797787 Nappi, 2005, Melanogenesis and associated cytotoxic reactions: applications to insect innate immunity, Insect Biochem. Mol. Biol., 35, 443, 10.1016/j.ibmb.2005.01.014 Park, 2010, Beetle immunity, vol. 708, 163 Peterson, 2012, Parallel reaction monitoring for high resolution and high mass accuracy quantitative, targeted proteomics, Mol. Cell. Proteomics, 11, 1475, 10.1074/mcp.O112.020131 Piao, 2005, Crystal structure of a clip-domain serine protease and functional roles of the clip domains, EMBO J., 24, 4404, 10.1038/sj.emboj.7600891 Povelones, 2013, The clip domain serine protease homolog SPCLIP1 regulates complement recruitment to microbial surfaces in the malaria mosquito Anopheles gambiae, PLoS Pathog., 9, 10.1371/journal.ppat.1003623 Rousset, 2010, The Drosophila serine protease homologue Scarface regulates JNK signaling in a negative-feedback loop during epithelial morphogenesis, Development, 137, 2177, 10.1242/dev.050781 Satoh, 1999, Prophenoloxidase-activating enzyme of the silkworm, Bombyx mori: purification, characterization, and cDNA cloning, J. Biol. Chem., 274, 7441, 10.1074/jbc.274.11.7441 Sousa, 2020, The clip-domain serine protease CLIPC9 regulates melanization downstream of SPCLIP1, CLIPA8, and CLIPA28 in the malaria vector Anopheles gambiae, PLoS Pathog., 16, 10.1371/journal.ppat.1008985 Sumathipala, 2010, Involvement of Manduca sexta peptidoglycan recognition protein-1 in the recognition of bacteria and activation of prophenoloxidase system, Insect Biochem. Mol. Biol., 40, 487, 10.1016/j.ibmb.2010.04.008 Volz, 2006, A genetic module regulates the melanization response of Anopheles to Plasmodium, Cell Microbiol., 8, 1392, 10.1111/j.1462-5822.2006.00718.x Wang, 2004, Prophenoloxidase (proPO) activation in Manduca sexta: an analysis of molecular interactions among proPO, proPO-activating proteiase-3, and a cofactor, Insect Biochem. Mol. Biol., 34, 731, 10.1016/j.ibmb.2004.03.008 Wang, 2014, Manduca sexta proprophenoloxidase activating proteinase-3 (PAP3) stimulates melanization by activating proPAP3, proSPHs, and proPOs, Insect Biochem. Mol. Biol., 50, 82, 10.1016/j.ibmb.2014.04.005 Yassine, 2014, A serine protease homolog negatively regulates TEP1 consumption in systemic infections of the malaria vector Anopheles gambiae, J. Innate Immun., 6, 806, 10.1159/000363296 Yu, 2003, Nonproteolytic serine protease homologs are involved in prophenoloxidase activation in the tobacco hornworm, Manduca sexta, Insect Biochem. Mol. Biol., 33, 197, 10.1016/S0965-1748(02)00191-1 Zhang, 2014, Semi-quantitative analysis of changes in the plasma peptidome of Manduca sexta larvae and their correlation with the transcriptome variations upon immune challenge, Insect Biochem. Mol. Biol., 47, 46, 10.1016/j.ibmb.2014.02.002 Zhao, 2007, Broad-spectrum antimicrobial activity of the reactive compounds generated in vitro by Manduca sexta phenoloxidase, Insect Biochem. Mol. Biol., 37, 952, 10.1016/j.ibmb.2007.05.001 Zhao, 2011, Antiviral, anti-parasitic, and cytotoxic effects of 5, 6-dihydroxyindole (DHI), a reactive compound generated by phenoloxidase during insect immune response, Insect Biochem. Mol. Biol., 41, 645, 10.1016/j.ibmb.2011.04.006