Claudin 1, 4 and 7 Expression in Malignant Melanoma
Tóm tắt
Claudins are an important members of tight junction proteins. While studies about the Claudin expression in epithelial tumors are common, studies concerning Claudin expression in malignant melanoma are rare. Investigating the expression of Claudins 1, 4, 7 in malignant melanoma, and if there is an expression, investigating its relation with unfavorable prognostic parameters such as lymphovascular invasion, ulceration, absence of lymphocytic response and presence of satellite nodules. Claudins 1, 4 and 7 were stained immunohistochemically in biopsy samples of 24 cutaneous malignant melanoma and 16 malignant melanoma metastatic to lymph node. There was no significant difference in Claudin 1, 4 and 7 expression between cutaneous and lymph node metastatic malignant melanoma. Claudin 1 expression was determined in all patients. In cutaneous malignant melanoma, no correlation was found between Claudin 1 and unfavorable prognostic parameters. There was a significant correlation between lymphovascular invasion and Claudin 4 positivity. The correlation of the presence of ulceration and satellite nodules with Claudin 7 positivity were significant. Investigations for Claudin expression in malignant melanoma is very rare in the literature and mostly about Claudin 1. The significant correlation between lymphovascular invasion and Claudin 4, and also the presence of ulceration and satellite nodules with Claudin 7 suggests that the role of abnormal expressed tight junction proteins are important and it presents as one of the involved mechanisms and indicator of aggressive behavior for malignant melanoma.
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