Cisplatinum and Taxol Induce Different Patterns of p53 Phosphorylation

Ko, 1996, p53: puzzle and paradigm, Genes Dev, 56, 2649 Levine, 1997, p53, the cellular gatekeeper for growth and division, Cell, 66, 323, 10.1016/S0092-8674(00)81871-1 Chen, 1996, p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells, Genes Dev, 10, 2438, 10.1101/gad.10.19.2438 Ullrich, 1992, The p53 tumor suppressor protein, a modulator of cell proliferation, J Biol Chem, 267, 15259, 10.1016/S0021-9258(19)49524-0 Wahl, 1996, Loss of normal p53 function confers sensitization to Taxol by increasing G2/M arrest and apoptosis, Nat Med, 2, 72, 10.1038/nm0196-72 Vikhanskaya, 1998, Inactivation of p53 in a human ovarian cancer cell line increases the sensitivity to paclitaxel by inducing G2/M arrest and apoptosis, Exp Cell Res, 241, 96, 10.1006/excr.1998.4018 O'Connor, 1997, Characterization of the p53 tumor suppressor pathway in cell lines of the National Cancer Institute anticancer drug screen and correlations with the growth-inhibitory potency of 123 anticancer agents, Cancer Res, 57, 4285 Fan, 1995, Disruption of p53 function sensitizes breast cancer MCF-7 cells to cisplatin and pentoxifylline, Cancer Res, 55, 1649 Eastman, 1983, Characterization of the adducts produced in DNA by cis-diamminedichloroplatinum (II) and cis-dichloro(ethylenediamine) platinum, Biochemistry, 22, 3927, 10.1021/bi00285a031 Horwitz, 1992, Mechanism of action of taxol, Trends Pharmacol Sci, 13, 134, 10.1016/0165-6147(92)90048-B Debernardis, 1997, p53 status does not affect sensitivity of human ovarian cancer cell lines to paclitaxel, Cancer Res, 57, 870 Tishler, 1995, Microtubuleactive drugs taxol, vinblastine, and nocodazole increase the levels of transcriptionally active p53, Cancer Res, 55, 6021 De Feudis, 1997, DDP-induced cytotoxicity is not influenced by p53 in nine human ovarian cancer cell lines with different p53 status, Br J Cancer, 76, 474, 10.1038/bjc.1997.412 Meek, 1998, Multisite phosphorylation and the integration of stress signals at p53, Cell Signal, 10, 159, 10.1016/S0898-6568(97)00119-8 Lane, 1998, Awakening angels, Nature, 394, 616, 10.1038/29166 Giaccia, 1998, The complexity of p53 modulation: emerging patterns from divergent signals, Genes Dev, 12, 2973, 10.1101/gad.12.19.2973 Kapoor, 1998, Functional activation of p53 via phosphorylation following DNA damage by UV but not gamma radiation, Proc Natl Acad Sci USA, 95, 2834, 10.1073/pnas.95.6.2834 Lu, 1998, Ultraviolet radiation, but not gamma radiation or etoposide-induced DNA damage, results in the phosphorylation of the murine p53 protein at serine-389, Proc Natl Acad Sci USA, 95, 6399, 10.1073/pnas.95.11.6399 Siliciano, 1997, DNA damage induces phosphorylation of the amino terminus of p53, Genes Dev, 11, 3471, 10.1101/gad.11.24.3471 Shieh, 1997, DNA damageinduced phosphorylation of p53 alleviates inhibition by MDM2, Cell, 91, 325, 10.1016/S0092-8674(00)80416-X Meek, 1997, Multi-site phosphorylation of p53 by protein kinases inducible by p53 and DNA damage, Biochem Soc Trans, 25, 416, 10.1042/bst0250416 Anderson, 1993, DNA damage and the DNA-activated protein kinase, Trends Biochem Sci, 18, 433, 10.1016/0968-0004(93)90144-C Woo, 1998, DNA-dependent protein kinase acts upstream of p53 in response to DNA damage, Nature, 394, 700, 10.1038/29343 Banin, 1998, Enhanced phosphorylation of p53 by ATM in response to DNA damage, Science, 281, 1674, 10.1126/science.281.5383.1674 Common, 1998, Activation of the ATM kinase by ionizing radiation and phosphorylation of p53, Science, 281, 1677, 10.1126/science.281.5383.1677 Liu, 1999, p53 sites acetylated in vitro by PCAF and p300 are acetylated in vivo in response to DNA damage, Mol Cell Blot, 19, 1202, 10.1128/MCB.19.2.1202 Gu, 1997, Activation of p53 sequence-specific DNA binding by acetylation of the p53 C-terminal domain, Cell, 90, 595, 10.1016/S0092-8674(00)80521-8 Hirao, 2000, DNA damage-induced activation of p53 by the checkpoint kinase Chk2, Science, 287, 1824, 10.1126/science.287.5459.1824 Shieh, 2000, The human homologs of checkpoint kinases Chkl and Cdsl (Chk2) phosphorylate p53 at multiple DNA damage -inducible sites, Genes Dev, 14, 289, 10.1101/gad.14.3.289 Chehab, 2000, Chk2/hCdsl functions as a DNA damage checkpoint in Gl by stabilizing p53, Genes Dev, 14, 278, 10.1101/gad.14.3.278 Allalunis-Turner, 1995, Lack of correlation between DNA-dependent protein kinase activity and tumor cell radiosensitivity, Cancer Res, 55, 5200 Sarkaria, 1998, Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin, Cancer Res, 58, 4375 Tibbetts, 1999, A role for ATR in the DNA damage-induced phosphorylation of p53, Genes Dev, 13, 152, 10.1101/gad.13.2.152 Westphal, 1997, Cell-cycle signaling: ATM displays its many talents, Curr Biol, 7, 789, 10.1016/S0960-9822(06)00406-4 Smith, 1999, The DNA-dependent protein kinase, Genes Dev, 13, 916, 10.1101/gad.13.8.916 Sakaguchi, 1997, Phosphorylation of serine 392 stabilizes the tetramer formation of tumor suppressor protein p53, Biochemistry, 36, 10117, 10.1021/bi970759w Sakaguchi, 1998, DNA damage activates p53 through a phosphorylation-acetylation cascade, Genes Dev, 12, 2831, 10.1101/gad.12.18.2831 Waterman, 1998, ATM-dependent activation of p53 involves dephosphorylation and association with 14-3-3 proteins, Nat Genet, 19, 175, 10.1038/542 Chehab, 1999, Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage, Proc Nall Acad Sci USA, 96, 13777, 10.1073/pnas.96.24.13777 Lees-Miller, 1992, Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53, Mol Cell Blot, 12, 5041, 10.1128/MCB.12.11.5041 Khanna, 1998, ATM associates with and phosphorylates p53: mapping the region of interaction, Nat Genet, 20, 398, 10.1038/3882 Prives, 1998, Signaling to p53: breaking the MDM2-p53 circuit, Cell, 95, 5, 10.1016/S0092-8674(00)81774-2 Lambert, 1998, Phosphorylation of p53 serine 15 increases interaction with CBP, J Biol Chem, 273, 33048, 10.1074/jbc.273.49.33048 Dumaz, 1999, Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2, EMBO J, 18, 7002, 10.1093/emboj/18.24.7002