Cis-acting elements responsible for dopaminergic neuron-specific expression of zebrafish slc6a3 (dopamine transporter) in vivo are located remote from the transcriptional start site

Neuroscience - Tập 164 - Trang 1138-1151 - 2009
Q. Bai1,2, E.A. Burton1,2,3,4,5
1Pittsburgh Institute for Neurodegenerative Diseases, University of Pittsburgh, School of Medicine, Pittsburgh, PA, USA
2Department of Neurology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
3Department of Microbiology and Molecular Genetics, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA
4Geriatric Research, Education and Clinical Center, Pittsburgh Veterans' Affairs Healthcare System, Pittsburgh, PA, USA
5Division of Movement Disorders, University of Pittsburgh Medical Center, Pittsburgh, PA, USA

Tài liệu tham khảo

Amsterdam, 1999, A large-scale insertional mutagenesis screen in zebrafish, Genes Dev, 13, 2713, 10.1101/gad.13.20.2713 Anichtchik, 2004, Neurochemical and behavioural changes in zebrafish Danio rerio after systemic administration of 6-hydroxydopamine and 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, J Neurochem, 88, 443, 10.1111/j.1471-4159.2004.02190.x Backman, 2006, Characterization of a mouse strain expressing Cre recombinase from the 3′ untranslated region of the dopamine transporter locus, Genesis, 44, 383, 10.1002/dvg.20228 Bai, 2007, Generation of a transgenic zebrafish model of Tauopathy using a novel promoter element derived from the zebrafish eno2 gene, Nucleic Acids Res, 35, 6501, 10.1093/nar/gkm608 Bai, 2006, Zebrafish DJ-1 is evolutionarily conserved and expressed in dopaminergic neurons, Brain Res, 1113, 33, 10.1016/j.brainres.2006.07.057 Bai, 2009, Expression of a 12-kb promoter element derived from the zebrafish enolase-2 gene in the zebrafish visual system, Neurosci Lett, 449, 252, 10.1016/j.neulet.2008.10.101 Blin, 2008, NR4A2 controls the differentiation of selective dopaminergic nuclei in the zebrafish brain, Mol Cell Neurosci, 39, 592, 10.1016/j.mcn.2008.08.006 Bretaud, 2007, p53-dependent neuronal cell death in a DJ-1-deficient zebrafish model of Parkinson's disease, J Neurochem, 100, 1626 Bretaud, 2004, Sensitivity of zebrafish to environmental toxins implicated in Parkinson's disease, Neurotoxicol Teratol, 26, 857, 10.1016/j.ntt.2004.06.014 Burton, 1999, A second promoter provides an alternative target for therapeutic up-regulation of utrophin in Duchenne muscular dystrophy, Proc Natl Acad Sci U S A, 96, 14025, 10.1073/pnas.96.24.14025 Donovan, 1995, Human and mouse dopamine transporter genes: conservation of 5′-flanking sequence elements and gene structures, Brain Res Mol Brain Res, 30, 327, 10.1016/0169-328X(95)00018-N Driever, 1996, A genetic screen for mutations affecting embryogenesis in zebrafish, Development, 123, 37, 10.1242/dev.123.1.37 Filippi, 2007, Expression and function of nr4a2, lmx1b, and pitx3 in zebrafish dopaminergic and noradrenergic neuronal development, BMC Dev Biol, 7, 135, 10.1186/1471-213X-7-135 Flames, 2009, Gene regulatory logic of dopamine neuron differentiation, Nature, 458, 885, 10.1038/nature07929 Foley, 2009, Rapid mutation of endogenous zebrafish genes using zinc finger nucleases made by Oligomerized Pool ENgineering (OPEN), PLoS One, 4, e4348, 10.1371/journal.pone.0004348 Gao, 2005, Transgenic zebrafish that express tyrosine hydroxylase promoter in inner retinal cells, Dev Dyn, 233, 921, 10.1002/dvdy.20416 Genro, 2008, A common haplotype at the dopamine transporter gene 5′ region is associated with attention-deficit/hyperactivity disorder, Am J Med Genet B Neuropsychiatr Genet, 147B, 1568, 10.1002/ajmg.b.30863 Giacomini, 2006, Antipsychotics produce locomotor impairment in larval zebrafish, Neurotoxicol Teratol, 28, 245, 10.1016/j.ntt.2006.01.013 Gong, 2003, A gene expression atlas of the central nervous system based on bacterial artificial chromosomes, Nature, 425, 917, 10.1038/nature02033 Guo, 1999, Mutations in the zebrafish unmask shared regulatory pathways controlling the development of catecholaminergic neurons, Dev Biol, 208, 473, 10.1006/dbio.1999.9204 Holzschuh, 2003, Genetic analysis of the roles of Hh, FGF8, and nodal signaling during catecholaminergic system development in the zebrafish brain, J Neurosci, 23, 5507, 10.1523/JNEUROSCI.23-13-05507.2003 Holzschuh, 2001, Dopamine transporter expression distinguishes dopaminergic neurons from other catecholaminergic neurons in the developing zebrafish embryo, Mech Dev, 101, 237, 10.1016/S0925-4773(01)00287-8 Kawarai, 1997, Structure and organization of the gene encoding human dopamine transporter, Gene, 195, 11, 10.1016/S0378-1119(97)00131-5 Kimmel, 1989, Genetics and early development of zebrafish, Trends Genet, 5, 283, 10.1016/0168-9525(89)90103-0 Kouzmenko, 1997, Intronic sequences are involved in neural targeting of human dopamine transporter gene expression, Biochem Biophys Res Commun, 240, 807, 10.1006/bbrc.1997.7754 Lam, 2005, Zebrafish embryos are susceptible to the dopaminergic neurotoxin MPTP, Eur J Neurosci, 21, 1758, 10.1111/j.1460-9568.2005.03988.x Lee, 2001, A highly efficient Escherichia coli-based chromosome engineering system adapted for recombinogenic targeting and subcloning of BAC DNA, Genomics, 73, 56, 10.1006/geno.2000.6451 Ma, 2003, Catecholaminergic systems in the zebrafish, J Comp Neurol, 460, 13, 10.1002/cne.10544 McCollum, 2007, A zebrafish LMO4 ortholog limits the size of the forebrain and eyes through negative regulation of six3b and rx3, Dev Biol, 309, 373, 10.1016/j.ydbio.2007.07.004 McKinley, 2005, Neuroprotection of MPTP-induced toxicity in zebrafish dopaminergic neurons, Brain Res Mol Brain Res, 141, 128, 10.1016/j.molbrainres.2005.08.014 McLean, 2008, Using imaging and genetics in zebrafish to study developing spinal circuits in vivo, Dev Neurobiol, 68, 817, 10.1002/dneu.20617 Meng, 2008, Targeting retinal dopaminergic neurons in tyrosine hydroxylase-driven green fluorescent protein transgenic zebrafish, Mol Vis, 14, 2475 Miller, 2005, CHIP suppresses polyglutamine aggregation and toxicity in vitro and in vivo, J Neurosci, 25, 9152, 10.1523/JNEUROSCI.3001-05.2005 Mongeon, 2008, Synaptic homeostasis in a zebrafish glial glycine transporter mutant, J Neurophysiol, 100, 1716, 10.1152/jn.90596.2008 Peters, 1995, Green fluorescent fusion proteins: powerful tools for monitoring protein expression in live zebrafish embryos, Dev Biol, 171, 252, 10.1006/dbio.1995.1276 Prober, 2006, Hypocretin/orexin overexpression induces an insomnia-like phenotype in zebrafish, J Neurosci, 26, 13400, 10.1523/JNEUROSCI.4332-06.2006 Reifers, 1998, Fgf8 is mutated in zebrafish acerebellar (ace) mutants and is required for maintenance of midbrain-hindbrain boundary development and somitogenesis, Development, 125, 2381, 10.1242/dev.125.13.2381 Rink, 2001, The teleostean (zebrafish) dopaminergic system ascending to the subpallium (striatum) is located in the basal diencephalon (posterior tuberculum), Brain Res, 889, 316, 10.1016/S0006-8993(00)03174-7 Rink, 2002, Development of the catecholaminergic system in the early zebrafish brain: an immunohistochemical study, Brain Res Dev Brain Res, 137, 89, 10.1016/S0165-3806(02)00354-1 Ryu, 2006, Genetic analysis of dopaminergic system development in zebrafish, J Neural Transm Suppl, 70, 61, 10.1007/978-3-211-45295-0_11 Sallinen, 2008, MPTP and MPP+ target specific aminergic cell populations in larval zebrafish, J Neurochem, 108, 719, 10.1111/j.1471-4159.2008.05793.x Solnica-Krezel, 1994, Efficient recovery of ENU-induced mutations from the zebrafish germline, Genetics, 136, 1401, 10.1093/genetics/136.4.1401 Tarnok, 2007, Dopaminergic candidate genes in Tourette syndrome: association between tic severity and 3′ UTR polymorphism of the dopamine transporter gene, Am J Med Genet B Neuropsychiatr Genet, 144B, 900, 10.1002/ajmg.b.30517 Thermes, 2002, I-SceI meganuclease mediates highly efficient transgenesis in fish, Mech Dev, 118, 91, 10.1016/S0925-4773(02)00218-6 Thirumalai, 2008, Endogenous dopamine suppresses initiation of swimming in prefeeding zebrafish larvae, J Neurophysiol, 100, 1635, 10.1152/jn.90568.2008 Torres, 2006, The dopamine transporter proteome, J Neurochem, 97, 3, 10.1111/j.1471-4159.2006.03719.x Wang, 2005, Sp1 and Sp3 activate transcription of the human dopamine transporter gene, J Neurochem, 93, 474, 10.1111/j.1471-4159.2005.03051.x Watts, 2004 Wen, 2008, Visualization of monoaminergic neurons and neurotoxicity of MPTP in live transgenic zebrafish, Dev Biol, 314, 84, 10.1016/j.ydbio.2007.11.012 Williams, 2008, Novel targets for Huntington's disease in an mTOR-independent autophagy pathway, Nat Chem Biol, 4, 295, 10.1038/nchembio.79 Zhuang, 2005, Targeted gene expression in dopamine and serotonin neurons of the mouse brain, J Neurosci Methods, 143, 27, 10.1016/j.jneumeth.2004.09.020 Zon, 2005, In vivo drug discovery in the zebrafish, Nat Rev Drug Discov, 4, 35, 10.1038/nrd1606