Circulating microRNA miR-21-5p, miR-150-5p and miR-30e-5p correlate with clinical status in late onset myasthenia gravis

Benatar, 2012, Recommendations for myasthenia gravis clinical trials, Muscle Nerve, 45, 909, 10.1002/mus.23330 Chen, 2016, The role of microRNAs in the pathogenesis of autoimmune diseases, Autoimmun. Rev., 15, 1171, 10.1016/j.autrev.2016.09.003 Gilhus, 2015, Myasthenia gravis: subgroup classification and therapeutic strategies, Lancet Neurol., 14, 1023, 10.1016/S1474-4422(15)00145-3 Hu, 2013, MicroRNA control in the development of systemic autoimmunity, Arthritis Res. Ther., 15, 202, 10.1186/ar4131 Kim, 2016, Circulating hsa-miR-30e-5p, hsa-miR-92a-3p, and hsa-miR-223-3p may be novel biomarkers in systemic lupus erythematosus, HLA, 88, 187, 10.1111/tan.12874 Kroesen, 2015, Immuno-miRs: critical regulators of T-cell development, function and ageing, Immunology, 144, 1, 10.1111/imm.12367 Meriggioli, 2009, Autoimmune myasthenia gravis: emerging clinical and biological heterogeneity, Lancet Neurol., 8, 475, 10.1016/S1474-4422(09)70063-8 Molin, 2018, Thymectomy lowers the myasthenia gravis biomarker miR-150-5p, Neurol. Neuroimmunol. Neuroinflamm., 5, 10.1212/NXI.0000000000000450 Nogales-Gadea, 2014, Analysis of serum miRNA profiles of myasthenia gravis patients, PLoS One, 9, 10.1371/journal.pone.0091927 Punga, 2018, Circulating microRNAs as potential biomarkers in myasthenia gravis patients, Ann. N. Y. Acad. Sci., 1412, 33, 10.1111/nyas.13510 Punga, 2014, Circulating miRNAs in myasthenia gravis: miR-150-5p as a new potential biomarker, Ann. Clin. Transl. Neurol., 1, 49, 10.1002/acn3.24 Punga, 2015, Disease specific signature of circulating miR-150-5p and miR-21-5p in myasthenia gravis patients, J. Neurol. Sci., 356, 90, 10.1016/j.jns.2015.06.019 Punga, 2016, Disease specific enrichment of circulating let-7 family microRNA in MuSK+ myasthenia gravis, J. Neuroimmunol., 292, 21, 10.1016/j.jneuroim.2016.01.003 Rostedt Punga, 2015, How clinical trials of myasthenia gravis can inform pre-clinical drug development, Exp. Neurol., 270, 78, 10.1016/j.expneurol.2014.12.022 Schmittgen, 2008, Analyzing real-time PCR data by the comparative C(T) method, Nat. Protoc., 3, 1101, 10.1038/nprot.2008.73 Weis, 2018, Challenging the current model of early-onset myasthenia gravis pathogenesis in the light of the MGTX trial and histological heterogeneity of thymectomy specimens, Ann. N. Y. Acad. Sci., 1413, 82, 10.1111/nyas.13563