Circular RNAs in heart failure

European Journal of Heart Failure - Tập 19 Số 6 - Trang 701-709 - 2017
Yvan Devaux1, Esther E. Creemers2, Reinier A. Boon3,4, Stanislas Werfel5, Thomas Thum6,7, Stefan Engelhardt8,5, Stefanie Dimmeler4, Iain Squire9
1Cardiovascular Research Unit, Luxembourg Institute of Health, Luxembourg, Luxembourg
2Experimental Cardiology, Academic Medical Center, Amsterdam, The Netherlands
3Department of Physiology, VU University Medical Center, Amsterdam, The Netherlands
4Institute of Cardiovascular Regeneration, Goethe-University, Frankfurt, Germany
5Institute of Pharmacology and Toxicology, Technical University Munich, Munich, Germany
6Institute of Molecular and Translational Therapeutic Strategies, Hannover Medical School, Hannover, Germany
7National Heart and Lung Institute, Imperial College London, London, UK
8German Center for Cardiovascular Research, partner site Munich Heart Alliance, Munich, Germany
9Department of Cardiovascular Sciences, University of Leicester, Leicester, UK

Tóm tắt

AbstractCardiovascular disease, and particularly heart failure, is still a serious health care issue for which novel treatments and biomarkers are needed. The RNA family comprises different subgroups, among which the small‐sized microRNAs and the larger long non‐coding RNAs have shown some potential to aid in moving personalized health care of heart failure patients a step forward. Here, members of the Cardiolinc network review the recent findings suggesting that the less well‐known circular RNAs may constitute a novel reservoir of therapeutic targets and biomarkers of heart failure. The knowledge of the mode of biogenesis of circular RNAs will first be reported, followed by a description of different features that make these RNA molecules of interest for the heart failure community. The functions of circular RNAs in the heart will be described, with some emphasis given to their regulation in the failing heart. Circulating in the bloodstream, circular RNAs have appeared as potential biomarkers and recent findings associated with the use of circular RNAs as heart failure biomarkers will be discussed. Finally, some directions for future research will be provided.

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Tài liệu tham khảo

10.1002/ejhf.592

10.1161/CIR.0000000000000435

10.1002/ejhf.580

10.1002/ejhf.679

10.1002/ejhf.438

10.1002/ejhf.401

10.1093/eurjhf/hft088

10.1038/nature11247

Ohno S., 1972, So much "junk" DNA in our genome, Brookhaven Symp Biol, 23, 366

Weinberg RA, 1991, The dark side of the genome, Technology Review, 94, 45

10.1016/j.molmed.2014.10.006

10.1038/nrcardio.2015.55

10.1152/physrev.00041.2015

10.1016/j.jacc.2015.12.051

10.1016/j.jacc.2016.06.040

10.1073/pnas.1405528111

10.1038/srep34985

10.1016/j.molcel.2013.08.017

10.1038/nsmb.2959

10.1101/gr.202895.115

10.1161/CIRCRESAHA.116.309568

10.1016/j.yjmcc.2016.07.007

10.1261/rna.035667.112

10.1371/annotation/f782282b-eefa-4c8d-985c-b1484e845855

10.1016/j.molcel.2014.08.019

10.1016/j.celrep.2014.12.002

10.1016/j.cell.2014.09.001

10.1016/j.cell.2015.02.014

10.7554/eLife.07540

10.1038/nm.2693

10.1016/j.jmb.2015.02.018

10.1093/eurheartj/ehv713

10.1038/nature11993

10.1371/journal.pone.0151753

10.1093/eurheartj/ehx501.P440

10.1161/CIRCRESAHA.115.306319

10.1007/s10741-007-9034-1

10.1093/eurheartj/ehu090

10.1093/eurjhf/hft076

10.1053/euhj.1999.2045

10.1161/CIRCGENETICS.113.000077

10.1002/ejhf.495

10.1002/ejhf.625

10.1161/CIRCRESAHA.110.218297

10.1371/journal.pone.0142237

10.1016/j.ijcard.2015.10.217

10.1093/eurjhf/hfr155

10.1093/eurjhf/hft018

10.1002/ejhf.517

10.1093/eurheartj/ehu180

10.1186/s12967-016-0926-5

Li D, 2013, Transcriptome analysis reveals distinct patterns of long noncoding RNAs in heart and plasma of mice with heart failure, PLoS One, 8

10.1126/scitranslmed.aaf1475

10.1038/nature13596

10.1161/CIRCRESAHA.114.303915

10.1161/CIRCRESAHA.115.303836

10.1371/journal.pgen.1001233

10.1016/j.cca.2015.02.018

10.1159/000445617

10.1371/journal.pone.0141214

10.3389/fgene.2014.00030

10.1016/j.bbamcr.2016.11.005

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European Journal of Heart Failure

Tập 19 Số 6

701-709

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