Ciprofloxacin triggers the apoptosis of human triple-negative breast cancer MDA-MB-231 cells via the p53/Bax/Bcl-2 signaling pathway

Torre, 2016, Global cancer incidence and mortality rates and trends-An update, Cancer Epidemiol Biomarkers Prev, 25, 16, 10.1158/1055-9965.EPI-15-0578

Yao, 2017, Triple-negative breast cancer: Is there a treatment on the horizon?, Oncotarget, 8, 1913, 10.18632/oncotarget.12284

Anders, 2008, Understanding and treating triple-negative breast cancer, Oncology (Williston Park), 22, 12331243

Wahba, 2015, Current approaches in treatment of triple-negative breast cancer, Cancer Biol Med, 12, 106

Wang, 2002, Cellular roles of DNA topoisomerases: A molecular perspective, Nat Rev Mol Cell Biol, 3, 430, 10.1038/nrm831

Tse-Dinh, 2007, Exploring DNA topoisomerases as targets of novel therapeutic agents in the treatment of infectious diseases, Infect Disord Drug Targets, 7, 3, 10.2174/187152607780090748

Kaur, 2015, DNA Topoisomerase II: promising target for anticancer drugs, Multi-Targeted Approach to Treatment of Cancer, 323, 10.1007/978-3-319-12253-3_20

Cowell, 2012, Mechanism of generation of therapy related leukemia in response to anti-topoisomerase II agents, Int J Environ Res Public Health, 9, 2075, 10.3390/ijerph9062075

Aldred, 2014, Mechanism of quinolone action and resistance, Biochemistry, 53, 1565, 10.1021/bi5000564

Seo, 2012, Fluoroquinolone-mediated inhibition of cell growth, S-G2/M cell cycle arrest, and apoptosis in canine osteosarcoma cell lines, PLoS One, 7, e42960, 10.1371/journal.pone.0042960

Herold, 2002, Ciprofloxacin induces apoptosis and inhibits proliferation of human colorectal carcinoma cells, Br J Cancer, 86, 443, 10.1038/sj.bjc.6600079

Yadav, 2012, Gatifloxacin induces S and G2-phase cell cycle arrest in pancreatic cancer cells via p21/p27/p53, PLoS One, 7, e47796, 10.1371/journal.pone.0047796

Yadav, 2015, Moxifloxacin and ciprofloxacin induces S-phase arrest and augments apoptotic effects of cisplatin in human pancreatic cancer cells via ERK activation, BMC Cancer, 15, 581, 10.1186/s12885-015-1560-y

Aranha, 2003, Suppression of human prostate cancer cell growth by ciprofloxacin is associated with cell cycle arrest and apoptosis, Int J Oncol, 22, 787

Aranha, 2000, Ciprofloxacin mediated cell growth inhibition, S/G2-M cell cycle arrest, and apoptosis in a human transitional cell carcinoma of the bladder cell line, Clin Cancer Res, 6, 891

Oliphant, 2002, Quinolones: A comprehensive review, Am Fam Physician, 65, 455

Talla, 2011, Oxidative stress induced by fluoroquinolones on treatment for complicated urinary tract infections in Indian patients, J Young Pharm, 3, 304, 10.4103/0975-1483.90242

Bisacchi, 2016, A 'Double-Edged' scaffold: Antitumor power within the antibacterial quinolone, Curr Med Chem, 23, 520, 10.2174/0929867323666151223095839

Arriola, 2008, Genomic analysis of the HER2/TOP2A amplicon in breast cancer and breast cancer cell lines, Lab Invest, 88, 491, 10.1038/labinvest.2008.19

Żaczek, 2012, Prognostic significance of TOP2A gene dosage in HER-2-negative breast cancer, Oncologist, 17, 1246, 10.1634/theoncologist.2012-0023

Shyur, 2010, Taiwanin A inhibits MCF-7 cancer cell activity through induction of oxidative stress, upregulation of DNA damage checkpoint kinases, and activation of p53 and FasL/Fas signaling pathways, Phytomedicine, 18, 16, 10.1016/j.phymed.2010.06.005

Panieri, 2016, ROS homeostasis and metabolism: A dangerous liason in cancer cells, Cell Death Dis, 7, e2253, 10.1038/cddis.2016.105

Blaydes, 2000, Synergistic activation of p53-dependent transcription by two cooperating damage recognition pathways, Oncogene, 19, 3829, 10.1038/sj.onc.1203773

Burns, 1999, The p53 pathway and apoptosis, J Cell Physiol, 181, 231, 10.1002/(SICI)1097-4652(199911)181:2<231::AID-JCP5>3.0.CO;2-L

Pietenpol, 2002, Cell cycle checkpoint signaling: Cell cycle arrest versus apoptosis, Toxicology, 181–182, 475, 10.1016/S0300-483X(02)00460-2

Elmore, 2007, Apoptosis: A review of programmed cell death, Toxicol Pathol, 35, 495, 10.1080/01926230701320337

Chavez, 2010, Triple negative breast cancer cell lines: One tool in the search for better treatment of triple negative breast cancer, Breast Dis, 32, 35, 10.3233/BD-2010-0307

Beberok, 2017, Lomefloxacin induces oxidative stress and apoptosis in COLO829 melanoma cells, Int J Mol Sci, 18, E2194, 10.3390/ijms18102194

Bai, 2014, Targeting apoptosis pathways for new cancer therapeutics, Annu Rev Med, 65, 139, 10.1146/annurev-med-010713-141310

Ferlay, 2015, Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012, Int J Cancer, 136, E359, 10.1002/ijc.29210

Kloskowski, 2012, Ciprofloxacin is a potential topoisomerase II inhibitor for the treatment of NSCLC, Int J Oncol, 41, 1943, 10.3892/ijo.2012.1653

Thadepalli, 2005, Antitumor activity of trovafloxacin in an animal model, In Vivo, 19, 269

Beberok, 2012, Impact of lomefloxacin on antioxidant enzymes activity in normal melanocytes HEMa-LP, Curr Issues Pharm Med Sci, 25, 426, 10.12923/j.2084-980X/25.4/a.18

Beberok, 2015, Effect of norfloxacin and moxifloxacin on melanin synthesis and antioxidant enzymes activity in normal human melanocytes, Mol Cell Biochem, 401, 107, 10.1007/s11010-014-2297-7

Beberok, 2015, Impact of sparfloxacin on melanogenesis and antioxidant defense system in normal human melanocytes HEMa-LP - An in vitro study, Pharmacol Rep, 67, 38, 10.1016/j.pharep.2014.07.015

Liou, 2010, Reactive oxygen species in cancer, Free Radic Res, 44, 479, 10.3109/10715761003667554

Hall, 1999, Review: The role of glutathione in the regulation of apoptosis, Eur J Clin Invest, 29, 238, 10.1046/j.1365-2362.1999.00447.x

Mirkovic, 1997, Resistance to radiation-induced apoptosis in Bcl-2-expressing cells is reversed by depleting cellular thiols, Oncogene, 15, 1461, 10.1038/sj.onc.1201310

Dai, 1999, Malignant cells can be sensitized to undergo growth inhibition and apoptosis by arsenic trioxide through modulation of the glutathione redox system, Blood, 93, 268, 10.1182/blood.V93.1.268

Blau, 2007, Moxifloxacin but not ciprofloxacin or azithromycin selectively inhibits IL-8, IL-6, ERK1/2, JNK, and NF-kappaB activation in a cystic fibrosis epithelial cell line, Am J Physiol Lung Cell Mol Physiol, 292, L343, 10.1152/ajplung.00030.2006

Beberok, 2017, Ciprofloxacin-mediated induction of S-phase cell cycle arrest and apoptosis in COLO829 melanoma cells, Pharmacol Rep, 70, 6, 10.1016/j.pharep.2017.07.007

Shah, 1994, Comparative pharmacokinetics and safety of ciprofloxacin 400 mg i.v. thrice daily versus 750 mg po twice daily, J Antimicrob Chemother, 33, 795, 10.1093/jac/33.4.795

Rohwedder, 1991, Penetration of ciprofloxacin and metabolites into human lung, bronchial and pleural tissue after 250 and 500 mg oral ciprofloxacin, Chemotherapy, 37, 229, 10.1159/000238860

Beberok, 2011, Interaction between ciprofloxacin and melanin: The effect on proliferation and melanization in melanocytes, Eur J Pharmacol, 669, 32, 10.1016/j.ejphar.2011.08.003

d'Ischia, 2015, Melanins and melanogenesis: From pigment cells to human health and technological applications, Pigment Cell Melanoma Res, 28, 520, 10.1111/pcmr.12393

Wyatt, 2006, Cutaneous metastatic breast carcinoma with melanocyte colonization: A clinical and dermoscopic mimic of malignant melanoma, Dermatol Surg, 32, 949