Chronological and Morphological Study of Heart Development in the Rat

Anatomical Record - Tập 295 Số 8 - Trang 1267-1290 - 2012
Marcela Salazar–García1,2, Revilla Monsalve María Cristina3, Palomino Garibay Miguel Angel4, Arteaga Martínez Manuel5,6, Sofia Díaz‐Cintra7, Patricia de la Rosa Santander7, Bladimir Roque‐Ramírez8, Sánchez Gómez Concepción2
1Laboratorio de Citología, Escuela Nacional de Ciencias Biológicas, IPN
2Laboratorio de Investigación en Biología del Desarrollo y Teratogénesis Experimental, Hospital Infantil de México Federico Gómez
3Unidad de Investigación en Enfermedades Metabólicas, Centro Médico Nacional Siglo XXI. Instituto Mexicano del Seguro Social
4Colegio Ciencia y Tecnología, Universidad Autónoma de la Ciudad de México, UACM
5Escuela de Medicina, Universidad Panamericana
6Facultad de Medicina, Universidad Nacional Autónoma de México
7Departamento de Neurobiología del Desarrollo y Neurofisiología, Instituto de Neurobiología, Campus UNAM-Juriquilla
8División de Investigación Biomédica, Subdirección de Enseñanza e Investigación, CMN "20 de Noviembre", ISSSTE

Tóm tắt

AbstractAdult and embryonic laboratory rats have been used as a mammalian model organism in biomedical research, descriptive and experimental cardiac embryology, and experimental teratology. There have been, however, considerable variations and discrepancies concerning the developmental staging of the rat embryo in the reported literature, which have resulted in several controversies and inconsistencies. Therefore, we carried out a careful anatomical and histological study of rat cardiac morphogenesis from the premorphogenetic period to the mature heart in a newborn pup. A correlation between the chronology and morphological features of the heart and embryo or newborn was made. We provide a simple and comprehensive guide relating the developmental timing and fate of the embryonic components of the heart and their morphological changes in the rat based on in vivo labeling studies in the chick. We also compare the timing of heart development in rats, humans, and mice. Anat Rec, 2012. © 2012 Wiley Periodicals, Inc.

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