Chronically administered islet amyloid polypeptide in rats serves as an adiposity inhibitor and regulates energy homeostasis

Butler, 1990, Effects of meal ingestion on plasma amylin concentration in NIDDM and nondiabetic humans, Diabetes, 39, 752, 10.2337/diab.39.6.752 Cooper, 1987, Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients, Proc Natl Acad Sci USA, 84, 8628, 10.1073/pnas.84.23.8628 Westermark, 1987, Amyloid fibrils in human insulinoma and islets of Langerhans of the diabetic cat are derived from a neuropeptide-like protein also present in normal islet cells, Proc Natl Acad Sci USA, 84, 3881, 10.1073/pnas.84.11.3881 Ohsawa, 1989, Islet amyloid polypeptide inhibits glucose-stimulated insulin secretion from isolated rat pancreatic islets, Biochem Biophys Res Commun, 160, 961, 10.1016/0006-291X(89)92529-1 Fehmann, 1990, Islet amyloid polypeptide (IAPP; amylin) influences the endocrine but not the exocrine rat pancreas, Biochem Biophys Res Commun, 167, 1102, 10.1016/0006-291X(90)90636-2 Broderick, 1991, Human and rat amylin have no effects on insulin secretion in isolated rat pancreatic islets, Biochem Biophys Res Commun, 177, 932, 10.1016/0006-291X(91)90628-K Leighton, 1988, Pancreatic amylin and calcitonin generelated peptide cause resistance to insulin in skeletal muscle in vitro, Nature, 335, 632, 10.1038/335632a0 Kassir, 1991, Lack of effect of islet amyloid polypeptide in causing insulin resistance in conscious dogs during euglycemic clamp studies, Diabetes, 40, 998, 10.2337/diab.40.8.998 D'Alessio, 1994, Pancreatic expression and secretion of human islet amyloid polypeptide in a transgenic mouse, Diabetes, 43, 1457, 10.2337/diab.43.12.1457 Ahren, 1998, Transgenic overexpression of human islet amyloid polypeptide inhibits insulin secretion and glucose elimination after gastric glucose gavage in mice, Diabetologia, 41, 1374, 10.1007/s001250051079 Bennet, 1994, Amylin tonally regulates arginine-stimulated insulin secretion in rats, Diabetologia, 37, 436, 10.1007/BF00408483 Wang, 1999, Islet amyloid polypeptide tonally inhibits beta-, alpha-, and delta-cell secretion in isolated rat pancreatic islets, Am J Physiol, 276, E19 Mather, 2002, Role of amylin in insulin secretion and action in humans: Antagonist studies across the spectrum of insulin sensitivity, Diabetes Metab Res Rev, 18, 118, 10.1002/dmrr.263 Cooper, 1988, Amylin found in amyloid deposits in human type 2 diabetes mellitus may be a hormone that regulates glycogen metabolism in skeletal muscle, Proc Natl Acad Sci USA, 85, 7763, 10.1073/pnas.85.20.7763 Young, 1994, Amylin regulation of fuel metabolism, J Cell Biochem, 55, 12, 10.1002/jcb.240550003 Ye, 2001, Evidence that amylin stimulates lipolysis in vivo: A possible mediator of induced insulin resistance, Am J Physiol Endocrinol Metab, 280, E562, 10.1152/ajpendo.2001.280.4.E562 Woods, 2000, Adiposity signals and the control of energy homeostasis, Nutrition, 16, 894, 10.1016/S0899-9007(00)00454-8 Arnelo, 1998, Sufficiency of postprandial plasma levels of islet amyloid polypeptide for suppression of feeding in rats, Am J Physiol, 275, R1537 Reidelberger, 2001, Comparative effects of amylin and cholecystokinin on food intake and gastric emptying in rats, Am J Physiol Regul Integr Comp Physiol, 280, R605, 10.1152/ajpregu.2001.280.3.R605 Blevins, 2000, Brain regions where cholecystokinin suppresses feeding in rats, Brain Res, 860, 1, 10.1016/S0006-8993(99)02477-4 Labarca, 1980, A simple, rapid, and sensitive DNA assay procedure, Anal Biochem, 102, 344, 10.1016/0003-2697(80)90165-7 Lust, 1975, The measurement of glycogen in tissues by amylo-alpha-1,4-alpha-1,6-glucosidase after the destruction of preexisting glucose, Anal Biochem, 68, 328, 10.1016/0003-2697(75)90712-5 Wang, 1998, In vitro influences between pancreatic adenocarcinoma cells and pancreatic islets, J Surg Res, 79, 13, 10.1006/jsre.1998.5393 Hellmer, 1989, Automatic luminometric kinetic assay of glycerol for lipolysis studies, Anal Biochem, 177, 132, 10.1016/0003-2697(89)90027-4 Permert, 1994, Islet amyloid polypeptide in patients with pancreatic cancer and diabetes, N Engl J Med, 330, 313, 10.1056/NEJM199402033300503 Wallberg-Henriksson, 1987, Reversibility of decreased insulin-stimulated glucose transport capacity in diabetic muscle with in vitro incubation. Insulin is not required, J Biol Chem, 262, 7665, 10.1016/S0021-9258(18)47618-1 Chomczynski, 1987, Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction, Anal Biochem, 162, 156, 10.1016/0003-2697(87)90021-2 Isaksson, 2002, Obstructive jaundice results in increased liver expression of uncoupling protein 2 and intact skeletal muscle glucose metabolism in the rat, Scand J Gastroenterol, 37, 104, 10.1080/003655202753387446 Furnsinn, 1994, Islet amyloid polypeptide inhibits insulin secretion in conscious rats, Am J Physiol, 267, E300 Huang, 1992, Hyperamylinemia, hyperinsulinemia, and insulin resistance in genetically obese LA/N-cp rats, Hypertension, 19, I101, 10.1161/01.HYP.19.1_Suppl.I101 Jamal, 1990, Islet amyloid polypeptide-like immunoreactivity (amylin) in rats treated with dexamethasone and streptozotocin, J Endocrinol, 126, 425, 10.1677/joe.0.1260425 Giesecke, 1989, Protein and amino acid metabolism during early starvation as reflected by excretion of urea and methylhistidines, Metabolism, 38, 1196, 10.1016/0026-0495(89)90159-5 Rushing, 2000, Amylin and insulin interact to reduce food intake in rats, Horm Metab Res, 32, 62, 10.1055/s-2007-978590 Arnelo, 1996, Effects of acute and chronic infusion of islet amyloid polypeptide on food intake in rats, Scand J Gastroenterol, 31, 83, 10.3109/00365529609031632 Arnelo, 1996, Chronic infusion of islet amyloid polypeptide causes anorexia in rats, Am J Physiol, 271, R1654 Arnelo, 2000, Effects of long-term infusion of anorexic concentrations of islet amyloid polypeptide on neuro-transmitters and neuropeptides in rat brain, Brain Res, 887, 391, 10.1016/S0006-8993(00)03070-5 Rushing, 2000, Amylin: A novel action in the brain to reduce body weight, Endocrinology, 141, 850, 10.1210/en.141.2.850 Dua, 1996, Leptin: A significant indicator of total body fat but not of visceral fat and insulin insensitivity in African-American women, Diabetes, 45, 1635, 10.2337/diab.45.11.1635 Cnop, 2002, The concurrent accumulation of intra-abdominal and subcutaneous fat explains the association between insulin resistance and plasma leptin concentrations: Distinct metabolic effects of two fat compartments, Diabetes, 51, 1005, 10.2337/diabetes.51.4.1005 Ar'Rajab, 1991, Effects of amidated rat islet amyloid polypeptide on glucose-stimulated insulin secretion in vivo and in vitro in rats, Eur J Pharmacol, 192, 443, 10.1016/0014-2999(91)90239-M Polonsky, 1988, Twenty-four-hour profiles and pulsatile patterns of insulin secretion in normal and obese subjects, J Clin Invest, 81, 442, 10.1172/JCI113339 Sowa, 1990, Islet amyloid polypeptide amide causes peripheral insulin resistance in vivo in dogs, Diabetologia, 33, 118, 10.1007/BF00401051 Castle, 1998, Amylinmediated inhibition of insulin-stimulated glucose transport in skeletal muscle, Am J Physiol, 275, E531 Zierath, 1992, Human islet amyloid polypeptide at pharmacological levels inhibits insulin and phorbol esterstimulated glucose transport in in vitro incubated human muscle strips, Diabetologia, 35, 26, 10.1007/BF00400848 Kissebah, 1996, Intra-abdominal fat: Is it a major factor in developing diabetes and coronary artery disease?, Diabetes Res Clin Pract, 30, 25, 10.1016/S0168-8227(96)80035-0 Chen, 1996, Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy, Proc Natl Acad Sci USA, 93, 14795, 10.1073/pnas.93.25.14795 Levin, 1996, Decreased food intake does not completely account for adiposity reduction after ob protein infusion, Proc Natl Acad Sci USA, 93, 1726, 10.1073/pnas.93.4.1726