Chronic psychological stress during adolescence induces sex-dependent adulthood inflammation, increased adiposity, and abnormal behaviors that are ameliorated by selective inhibition of soluble tumor necrosis factor with XPro1595

Albert, 1988, Cohabitation with a female activates testosterone-dependent social aggression in male rats independently of changes in serum testosterone concentration, Physiol. Behav., 44, 735, 10.1016/0031-9384(88)90054-6 Bale, 2015, Sex differences and stress across the lifespan, Nat. Neurosci., 18, 1413, 10.1038/nn.4112 Barnum, 2014, Peripheral administration of the selective inhibitor of soluble tumor necrosis factor (TNF) XPro(R)1595 attenuates nigral cell loss and glial activation in 6-OHDA hemiparkinsonian rats, J. Parkinson's Dis., 4, 349, 10.3233/JPD-140410 Barnum, 2012, Psychological stress in adolescent and adult mice increases neuroinflammation and attenuates the response to LPS challenge, J. Neuroinflammation, 9, 9, 10.1186/1742-2094-9-9 Baumeister, 2016, Childhood trauma and adulthood inflammation: a meta-analysis of peripheral C-reactive protein, interleukin-6 and tumour necrosis factor-alpha, Mol. Psychiatry, 21, 642, 10.1038/mp.2015.67 Bayer, 1982, Changes in the total number of dentate granule cells in juvenile and adult rats: a correlated volumetric and 3H-thymidine autoradiographic study, Exp. Brain Res., 46, 315, 10.1007/BF00238626 Bechara, 2002, Decision-making and addiction (part I): impaired activation of somatic states in substance dependent individuals when pondering decisions with negative future consequences, Neuropsychologia, 40, 1675, 10.1016/S0028-3932(02)00015-5 Besedovsky, 2000, The cytokine-HPA axis feed-back circuit, Z. Rheumatol., 59 Boeck, 2016, Inflammation in adult women with a history of child maltreatment: the involvement of mitochondrial alterations and oxidative stress, Mitochondrion, 30, 197, 10.1016/j.mito.2016.08.006 Bohn, 1991, Glial cells express both mineralocorticoid and glucocorticoid receptors, J. Steroid Biochem. Mol. Biol., 40, 105, 10.1016/0960-0760(91)90173-3 Bourke, 2011, Behavioral effects of chronic adolescent stress are sustained and sexually dimorphic, Horm. Behav., 60, 112, 10.1016/j.yhbeh.2011.03.011 Braun, 2009, Juvenile separation stress induces rapid region- and layer-specific changes in S100ss- and glial fibrillary acidic protein-immunoreactivity in astrocytes of the rodent medial prefrontal cortex, Neuroscience, 160, 629, 10.1016/j.neuroscience.2009.02.074 Carpenter, 2007, Decreased adrenocorticotropic hormone and cortisol responses to stress in healthy adults reporting significant childhood maltreatment, Biol. Psychiatry, 62, 1080, 10.1016/j.biopsych.2007.05.002 Carpenter, 2010, Association between plasma IL-6 response to acute stress and early-life adversity in healthy adults, Neuropsychopharmacology, 35, 2617, 10.1038/npp.2010.159 Carpenter, 2011, Effect of childhood physical abuse on cortisol stress response, Psychopharmacology, 214, 367, 10.1007/s00213-010-2007-4 Carroll, 2008, Body mass index, abdominal adiposity, obesity, and cardiovascular reactions to psychological stress in a large community sample, Psychosom. Med., 70, 653, 10.1097/PSY.0b013e31817b9382 Caruso, 2017, Exposure to chronic variable social stress during adolescence alters affect-related behaviors and adrenocortical activity in adult male and female inbred mice, Dev. Psychobiol., 59, 679, 10.1002/dev.21541 Chen, 2008, Vasopressin does not mediate hypersensitivity of the hypothalamic pituitary adrenal axis during chronic stress, Ann. N. Y. Acad. Sci., 1148, 349, 10.1196/annals.1410.037 Crowell, 2015, Cumulative adversity in early childhood is associated with increased BMI and behavioural problems, Evid. Based Nurs., 18, 48, 10.1136/eb-2014-101878 Dahmen, 2018, Effects of early-life adversity on hippocampal structures and associated HPA axis functions, Dev. Neurosci., 40, 13, 10.1159/000484238 Demuyser, 2016, In-depth behavioral characterization of the corticosterone mouse model and the critical involvement of housing conditions, Physiol. Behav., 156, 199, 10.1016/j.physbeh.2015.12.018 Eiland, 2012, Chronic juvenile stress produces corticolimbic dendritic architectural remodeling and modulates emotional behavior in male and female rats, Psychoneuroendocrinology, 37, 39, 10.1016/j.psyneuen.2011.04.015 Elwenspoek, 2017, Proinflammatory T cell status associated with early life adversity, J. Immunol., 199, 4046, 10.4049/jimmunol.1701082 Elwenspoek, 2017, The effects of early life adversity on the immune system, Psychoneuroendocrinology, 82, 140, 10.1016/j.psyneuen.2017.05.012 Elzinga, 2008, Diminished cortisol responses to psychosocial stress associated with lifetime adverse events a study among healthy young subjects, Psychoneuroendocrinology, 33, 227, 10.1016/j.psyneuen.2007.11.004 Engert, 2010, Perceived early-life maternal care and the cortisol response to repeated psychosocial stress, J. Psychiatry Neurosci., 35, 370, 10.1503/jpn.100022 Eriksson, 2014, Early life stress and later health outcomes–findings from the Helsinki Birth Cohort Study, Am J Hum Biol, 26, 111, 10.1002/ajhb.22502 Felger, 2016, Inflammation is associated with decreased functional connectivity within corticostriatal reward circuitry in depression, Mol. Psychiatry, 21, 1358, 10.1038/mp.2015.168 Ganguly, 2015, Broken or maladaptive? Altered trajectories in neuroinflammation and behavior after early life adversity, Dev. Cogn. Neurosci., 11, 18, 10.1016/j.dcn.2014.07.001 Green, 2018, Developmental expression of anxiety and depressive behaviours after prenatal predator exposure and early life homecage enhancement, Behav. Brain Res., 346, 122, 10.1016/j.bbr.2017.11.028 Green, 2012, A role for interleukin-1beta in determining the lineage fate of embryonic rat hippocampal neural precursor cells, Mol. Cell. Neurosci., 49, 311, 10.1016/j.mcn.2012.01.001 Haller, 2014, Effects of adverse early-life events on aggression and anti-social behaviours in animals and humans, J. Neuroendocrinol., 26, 724, 10.1111/jne.12182 Hattay, 2017, Psychological stress-induced colonic barrier dysfunction: Role of immune-mediated mechanisms, Neurogastroenterol. Motil., 29 He, 2007, Neurogenesis decreases during brain maturation from adolescence to adulthood, Pharmacol. Biochem. Behav., 86, 327, 10.1016/j.pbb.2006.11.003 Heim, 2001, The role of childhood trauma in the neurobiology of mood and anxiety disorders: preclinical and clinical studies, Biol. Psychiatry, 49, 1023, 10.1016/S0006-3223(01)01157-X Hewson-Bower, 1996, Secretory immunoglobulin A increases during relaxation in children with and without recurrent upper respiratory tract infections, J. Dev. Behav. Pediatr., 17, 311, 10.1097/00004703-199610000-00004 Hong, 2012, Social isolation in adolescence alters behaviors in the forced swim and sucrose preference tests in female but not in male rats, Physiol. Behav., 105, 269, 10.1016/j.physbeh.2011.08.036 Hueston, 2017, Adolescent social isolation stress unmasks the combined effects of adolescent exercise and adult inflammation on hippocampal neurogenesis and behavior, Neuroscience, 365, 226, 10.1016/j.neuroscience.2017.09.020 Hueston, 2014, The inflamed axis: the interaction between stress, hormones, and the expression of inflammatory-related genes within key structures comprising the hypothalamic-pituitary-adrenal axis, Physiol. Behav., 124, 77, 10.1016/j.physbeh.2013.10.035 Isgor, 2004, Delayed effects of chronic variable stress during peripubertal-juvenile period on hippocampal morphology and on cognitive and stress axis functions in rats, Hippocampus, 14, 636, 10.1002/hipo.10207 Joung, 2014, Early life adversity is associated with elevated levels of circulating leptin, irisin, and decreased levels of adiponectin in midlife adults, J. Clin. Endocrinol. Metab., 99, E1055, 10.1210/jc.2013-3669 Kaneko, 2006, Suppression of cell proliferation by interferon-alpha through interleukin-1 production in adult rat dentate gyrus, Neuropsychopharmacology, 31, 2619, 10.1038/sj.npp.1301137 Kapuku, 2002, Relationships among socioeconomic status, stress induced changes in cortisol, and blood pressure in African American males, Ann. Behav. Med., 24, 320, 10.1207/S15324796ABM2404_08 Kessler, 2010, Childhood adversities and adult psychopathology in the WHO World Mental Health Surveys, Br. J. Psychiatry, 197, 378, 10.1192/bjp.bp.110.080499 Knoth, 2010, Murine features of neurogenesis in the human hippocampus across the lifespan from 0 to 100 years, PLoS One, 5, 10.1371/journal.pone.0008809 Lee, 2017, Probiotics reduce repeated water avoidance stress-induced colonic microinflammation in Wistar rats in a sex-specific manner, PLoS One, 12, 10.1371/journal.pone.0188992 Leussis, 2008, Is adolescence a sensitive period for depression? Behavioral and neuroanatomical findings from a social stress model, Synapse, 62, 22, 10.1002/syn.20462 Lovallo, 2013, Early life adversity reduces stress reactivity and enhances impulsive behavior: implications for health behaviors, Int. J. Psychophysiol., 90, 8, 10.1016/j.ijpsycho.2012.10.006 Lovallo, 2012, Lifetime adversity leads to blunted stress axis reactivity: studies from the Oklahoma Family Health Patterns Project, Biol. Psychiatry, 71, 344, 10.1016/j.biopsych.2011.10.018 Lynch, 2002, Interleukin-1 beta exerts a myriad of effects in the brain and in particular in the hippocampus: analysis of some of these actions, Vitam. Horm., 64, 185, 10.1016/S0083-6729(02)64006-3 Macht, 2018, Chronic stress from adolescence to aging in the prefrontal cortex: a neuroimmune perspective, Front. Neuroendocrinol., 49, 31, 10.1016/j.yfrne.2017.12.001 McCormick, 2015, Peer pressures: social instability stress in adolescence and social deficits in adulthood in a rodent model, Dev. Cogn. Neurosci., 11, 2, 10.1016/j.dcn.2014.04.002 McCormick, 2007, HPA function in adolescence: role of sex hormones in its regulation and the enduring consequences of exposure to stressors, Pharmacol. Biochem. Behav., 86, 220, 10.1016/j.pbb.2006.07.012 Menard, 2017, Social stress induces neurovascular pathology promoting depression, Nat. Neurosci., 20, 1752, 10.1038/s41593-017-0010-3 Merrick, 2018, Prevalence of adverse childhood experiences from the 2011-2014 behavioral risk factor surveillance system in 23 states, JAMA Pediatr., 10.1001/jamapediatrics.2018.2537 Miller, 2007, Unfavorable socioeconomic conditions in early life presage expression of proinflammatory phenotype in adolescence, Psychosom. Med., 69, 402, 10.1097/PSY.0b013e318068fcf9 Moy, 2004, Sociability and preference for social novelty in five inbred strains: an approach to assess autistic-like behavior in mice, Genes Brain Behav., 3, 287, 10.1111/j.1601-1848.2004.00076.x Osler, 2016, Stressful life events and leucocyte telomere length: do lifestyle factors, somatic and mental health, or low grade inflammation mediate this relationship? Results from a cohort of Danish men born in 1953, Brain Behav. Immun., 58, 248, 10.1016/j.bbi.2016.07.154 Ouellet-Morin, 2011, Blunted cortisol responses to stress signal social and behavioral problems among maltreated/bullied 12-year-old children, Biol. Psychiatry, 70, 1016, 10.1016/j.biopsych.2011.06.017 Pace, 2013, Engagement with cognitively-based compassion training is associated with reduced salivary C-reactive protein from before to after training in foster care program adolescents, Psychoneuroendocrinology, 38, 294, 10.1016/j.psyneuen.2012.05.019 Palma-Gudiel, 2015, Glucocorticoid receptor gene (NR3C1) methylation processes as mediators of early adversity in stress-related disorders causality: a critical review, Neurosci. Biobehav. Rev., 55, 520, 10.1016/j.neubiorev.2015.05.016 Paolicelli, 2011, Synaptic pruning by microglia is necessary for normal brain development, Science, 333, 1456, 10.1126/science.1202529 Papp, 1991, An animal model of anhedonia: attenuation of sucrose consumption and place preference conditioning by chronic unpredictable mild stress, Psychopharmacology, 104, 255, 10.1007/BF02244188 Perlman, 2007, Age-related differences in glucocorticoid receptor mRNA levels in the human brain, Neurobiol. Aging, 28, 447, 10.1016/j.neurobiolaging.2006.01.010 Pohl, 2015, Early-life stress origins of gastrointestinal disease: animal models, intestinal pathophysiology, and translational implications, Am. J. Physiol., 309, G927 Pyter, 2013, Sex differences in the effects of adolescent stress on adult brain inflammatory markers in rats, Brain Behav. Immun., 30, 88, 10.1016/j.bbi.2013.01.075 Ros-Simo, 2012, Early-life social experiences in mice affect emotional behaviour and hypothalamic-pituitary-adrenal axis function, Pharmacol. Biochem. Behav., 102, 434, 10.1016/j.pbb.2012.06.001 Roth, 2012, Effects of chronic plus acute prolonged stress on measures of coping style, anxiety, and evoked HPA-axis reactivity, Neuropharmacology, 63, 1118, 10.1016/j.neuropharm.2012.07.034 Rowson, 2016, Neuroinflammation and behavior in HIV-1 transgenic rats exposed to chronic adolescent stress, Front. Psychiatry, 7, 102, 10.3389/fpsyt.2016.00102 Sapolsky, 1986, Maturation of the adrenocortical stress response: neuroendocrine control mechanisms and the stress hyporesponsive period, Brain Res., 396, 64, 10.1016/0165-0173(86)90010-X Schneider, 2013, Adolescence as a vulnerable period to alter rodent behavior, Cell Tissue Res., 354, 99, 10.1007/s00441-013-1581-2 Schutte, 2014, A meta-analytic review of the effects of mindfulness meditation on telomerase activity, Psychoneuroendocrinology, 42, 45, 10.1016/j.psyneuen.2013.12.017 Schwaiger, 2016, Altered stress-induced regulation of genes in monocytes in adults with a history of childhood adversity, Neuropsychopharmacology, 41, 2530, 10.1038/npp.2016.57 Sher, 1991, Characteristics of children of alcoholics: putative risk factors, substance use and abuse, and psychopathology, J. Abnorm. Psychol., 100, 427, 10.1037/0021-843X.100.4.427 Shirtcliff, 2009, Early childhood stress is associated with elevated antibody levels to herpes simplex virus type 1, Proc. Natl. Acad. Sci. U.S.A., 106, 2963, 10.1073/pnas.0806660106 Sierra, 2008, Steroid hormone receptor expression and function in microglia, Glia, 56, 659, 10.1002/glia.20644 Sirevaag, 1991, Plasticity of GFAP-immunoreactive astrocyte size and number in visual cortex of rats reared in complex environments, Brain Res., 540, 273, 10.1016/0006-8993(91)90517-Y Sorocco, 2006, Blunted hypothalamic-pituitary-adrenocortical axis responsivity to stress in persons with a family history of alcoholism, Int. J. Psychophysiol., 59, 210, 10.1016/j.ijpsycho.2005.10.009 Sorrells, 2014, Glucocorticoids increase excitotoxic injury and inflammation in the hippocampus of adult male rats, Neuroendocrinology, 100, 129, 10.1159/000367849 Sterlemann, 2008, Long-term behavioral and neuroendocrine alterations following chronic social stress in mice: implications for stress-related disorders, Horm. Behav., 53, 386, 10.1016/j.yhbeh.2007.11.001 Tarter, 2004, Neurobehavior disinhibition in childhood predisposes boys to substance use disorder by young adulthood: direct and mediated etiologic pathways, Drug Alcohol Depend., 73, 121, 10.1016/j.drugalcdep.2003.07.004 Tomasdottir, 2015, Self reported childhood difficulties, adult multimorbidity and allostatic load. A cross-sectional analysis of the Norwegian HUNT study, PLoS One, 10, 10.1371/journal.pone.0130591 Tsai, 2014, Social instability stress differentially affects amygdalar neuron adaptations and memory performance in adolescent and adult rats, Front. Behav. Neurosci., 8, 27, 10.3389/fnbeh.2014.00027 Tursich, 2014, Association of trauma exposure with proinflammatory activity: a transdiagnostic meta-analysis, Transl. Psychiatry, 4, 10.1038/tp.2014.56 Van Eldik, 2003, The Janus face of glial-derived S100B: beneficial and detrimental functions in the brain, Restor. Neurol. Neurosci., 21, 97 Weber, 2017, Repeated social defeat, neuroinflammation, and behavior: monocytes carry the signal, Neuropsychopharmacology, 42, 46, 10.1038/npp.2016.102 West, 2016, Effects of Saccharomyces cerevisiae or boulardii yeasts on acute stress induced intestinal dysmotility, World J. Gastroenterol., 22, 10532, 10.3748/wjg.v22.i48.10532