Chronic minocycline administration improves spermatogenesis in rats

Nair, 2018, Minocycline: the second important antimicrobial in multidrug-resistant Acinetobacter baumanii infections, J Anaesthesiol Clin Pharmacol, 34, 140, 10.4103/joacp.JOACP_156_17 Saivin, 1998, Clinical pharmacokinetics of doxycycline and minocycline, Clin Pharmacokinet, 15, 355, 10.2165/00003088-198815060-00001 Garrido-Mesa, 2013, Minocycline: far beyond an antibiotic, Brit J Pharmacol, 169, 337, 10.1111/bph.12139 Yau, 2018, Chronic minocycline treatment improves hippocampal neuronal structure, NMDA receptor function, and memory processing in Fmr1 knockout mice, Neurobiol Dis, 113, 11, 10.1016/j.nbd.2018.01.014 Caires, 2012, VEGFA family isoforms regulate spermatogonial stem cell homeostasis in vivo, Endocrinology, 153, 887, 10.1210/en.2011-1323 Sharpe, 2010, Environmental/lifestyle effects on spermatogenesis, Philos Trans R Soc Lond Ser B: Biol Sci, 365, 1697, 10.1098/rstb.2009.0206 Malallah, 1992, Effect of minocycline on the sperm count and activity in infertile men with high pus cell count in their seminal fluid, J Chemother, 4, 286, 10.1080/1120009X.1992.11739179 Orazizadeh, 2009, Protective effect of minocycline on dexamethasone induced testicular germ cell apoptosis in mice, Eur Rev Med Pharmacol Sci, 13, 1 Nair, 2016, A simple practice guide for dose conversion between animals and human, J Basic Clin Pharma, 7, 27, 10.4103/0976-0105.177703 Seed, 1996, Methods for assessing sperm motility, morphology, and counts in the rat, rabbit, and dog: a consensus report. ILSI Risk Science Institute Expert Working Group on Sperm Evaluation, Reprod Toxicol, 10, 237, 10.1016/0890-6238(96)00028-7 Dehghani, 2013, Protective effects of l-carnitine and homogenized testis tissue on the testis and sperm parameters of busulfan-induced infertile male rats, Iran J Reprod Med, 11, 693 Johnsen, 1970, Testicular biopsy score count a method for registration of spermatogenesis in human testis, Hormones, 1, 2 Dhanapal, 2012, Reversible antispermatogenic and antisteroidogenic activities of Feronia limonia fruit pulp in adult male rats, Asian Pac J Trop Biomed, 2, 684, 10.1016/S2221-1691(12)60210-X Swerdloff, 1998, Hormonal regulation of germ cell apoptosis, 150 Kaviani, 2019, Amelioration of the apoptosis-mediated death in isolated human pancreatic islets by minocycline, Eur J Pharmacol, 5, 172518, 10.1016/j.ejphar.2019.172518 Castanares, 2005, Minocycline up-regulates BCL-2 levels in mitochondria and attenuates male germ cell apoptosis, Biochem Biophys Res Commun, 337, 663, 10.1016/j.bbrc.2005.09.101 Lue, 2003, Functional role of inducible nitric oxide synthase in the induction of male germ cell apoptosis. Regulation of sperm number, and determination of testes size: evidence from null mutant mice, Endocrinology, 144, 3092, 10.1210/en.2002-0142 Sadowski, 2001, Minocycline inhibits the production of inducible nitric oxide synthase in articular chondrocytes, J Rheumatol, 28, 336 Jinzhao, 2004, Minocycline up-regulates Bcl-2 and protects against cell death in mitochondria, J Biol Chem, 279, 19948, 10.1074/jbc.M313629200