Chronic exposure to excess iron promotes EMT and cancer via p53 loss in pancreatic cancer
Tài liệu tham khảo
Kozlowski, 2014, General aspects of metal toxicity, Curr Med Chem, 21, 3721, 10.2174/0929867321666140716093838
Porter, 2016, New insights into transfusion-related iron toxicity: implications for the oncologist, Crit Rev Oncol Hematol, 99, 261, 10.1016/j.critrevonc.2015.11.017
Dutra, 2014, Heme on innate immunity and inflammation, Front Pharmacol, 5, 115, 10.3389/fphar.2014.00115
Hooda, 2014, Heme, an essential nutrient from dietary proteins, critically impacts diverse physiological and pathological processes, Nutrients, 6, 1080, 10.3390/nu6031080
Babitt, 2011, The molecular pathogenesis of hereditary hemochromatosis, Semin Liver Dis, 31, 280, 10.1055/s-0031-1286059
Pietrangelo, 2011, Non-HFE hepatic iron overload, Semin Liver Dis, 31, 302, 10.1055/s-0031-1286061
Ganz, 2012, Hepcidin and iron homeostasis, Biochim Biophys Acta, 1823, 1434, 10.1016/j.bbamcr.2012.01.014
Kew, 2014, Hepatic iron overload and hepatocellular carcinoma, Liver Cancer, 3, 31, 10.1159/000343856
Torti, 2013, Iron and cancer: more ore to be mined, Nat Rev Cancer, 13, 342, 10.1038/nrc3495
Bystrom, 2015, Cancer cells with irons in the fire, Free Radic Biol Med, 79, 337, 10.1016/j.freeradbiomed.2014.04.035
Cross, 2007, A prospective study of red and processed meat intake in relation to cancer risk, PLoS Med, 4, e325, 10.1371/journal.pmed.0040325
Bastide, 2011, Heme iron from meat and risk of colorectal cancer: a meta-analysis and a review of the mechanisms involved, Cancer Prev Res (Phila), 4, 177, 10.1158/1940-6207.CAPR-10-0113
Qiao, 2013, Intakes of heme iron and zinc and colorectal cancer incidence: a meta-analysis of prospective studies, Cancer Causes Control, 24, 1175, 10.1007/s10552-013-0197-x
Shen, 2014, Iron metabolism regulates p53 signaling through direct heme-p53 interaction and modulation of p53 localization, stability, and function, Cell Rep, 7, 180, 10.1016/j.celrep.2014.02.042
Grippo, 2003, Preinvasive pancreatic neoplasia of ductal phenotype induced by acinar cell targeting of mutant kras in transgenic mice, Cancer Res, 63, 2016
Levy, 2000, Genes that modify the hemochromatosis phenotype in mice, J Clin Invest, 105, 1209, 10.1172/JCI9635
Coothankandaswamy, 2016, Amino acid transporter SLC6A14 is a novel and effective drug target for pancreatic cancer, Br J Pharmacol, 173, 3292, 10.1111/bph.13616
Bhutia, 2015, Interferon-gamma induces a tryptophan-selective amino acid transporter in human colonic epithelial cells and mouse dendritic cells, Biochim Biophys Acta, 1848, 453, 10.1016/j.bbamem.2014.10.021
Gnanaprakasam, 2009, Absence of iron-regulatory protein hfe results in hyperproliferation of retinal pigment epithelium: role of cystine/glutamate exchanger, Biochem J, 424, 243, 10.1042/BJ20090424
Gnanaprakasam, 2013, Loss of hfe leads to progression of tumor phenotype in primary retinal pigment epithelial cells, Invest Ophthalmol Vis Sci, 54, 63, 10.1167/iovs.12-10312
Menendez, 2009, The expanding universe of p53 targets, Nat Rev Cancer, 9, 724, 10.1038/nrc2730
Levine, 2009, The first 30 years of p53: growing ever more complex, Nat Rev Cancer, 9, 749, 10.1038/nrc2723
Bieging, 2014, Unravelling mechanisms of p53-mediated tumour suppression, Nat Rev Cancer, 14, 359, 10.1038/nrc3711
Fotiadis, 2013, The SLC3 and SLC7 families of amino acid transporters, Mol Aspects Med, 3, 139, 10.1016/j.mam.2012.10.007
Lewerenz, 2013, The cystine/glutamate antiporter system x(c)(-) in health and disease: from molecular mechanisms to novel therapeutic opportunities, Antioxid Redox Signal, 18, 522, 10.1089/ars.2011.4391
Stepulak, 2014, Glutamate and its receptors in cancer, J Neural Transm (Vienna), 121, 933, 10.1007/s00702-014-1182-6
Hu, 2014, Hypoxia-inducible factors enhance glutamate signaling in cancer cells, Oncotarget, 5, 8853, 10.18632/oncotarget.2593
Yang, 2016, Ferroptosis: death by lipid peroxidation, Trends Cell Biol, 26, 165, 10.1016/j.tcb.2015.10.014
Bridges, 2001, Structure, function, and regulation of human cystine/glutamate transporter in retinal pigment epithelial cells, Invest Ophthalmol Vis Sci, 42, 47
Xu, 2008, Wilson disease and hepatocellular carcinoma, Gastroenterol Hepatol, 49, 438
McBride, 2014, Li-Fraumeni syndrome: cancer risk assessment and clinical management, Nat Rev Clin Oncol, 11, 260, 10.1038/nrclinonc.2014.41
Bhutia, 2015, Amino acid transporters in cancer and their relevance to “glutamine addiction”: novel targets for the design of a new class of anticancer drugs, Cancer Res, 75, 1782, 10.1158/0008-5472.CAN-14-3745
Weisz, 2007, Transcription regulation by mutant p53, Oncogene, 26, 2202, 10.1038/sj.onc.1210294
Cooksey, 2004, Oxidative stress, beta-cell apoptosis, and decreased insulin secretory capacity in mouse models of hemochromatosis, Endocrinology, 145, 5305, 10.1210/en.2004-0392
Principe, 2016, TGFβ signaling in the pancreatic tumor microenvironment promotes fibrosis and immune evasion to facilitate tumorigenesis, Cancer Res, 76, 2525, 10.1158/0008-5472.CAN-15-1293
Lunova, 2017, Hepcidin knockout mice spontaneously develop chronic pancreatitis owing to cytoplasmic iron overload in acinar cells, J Pathol, 241, 104, 10.1002/path.4822
Altamura, 2014, Resistance of ferroportin to hepcidin binding causes exocrine pancreatic failure and fatal iron overload, Cell Metab, 20, 359, 10.1016/j.cmet.2014.07.007