Chronic cough and laryngeal dysfunction improve with specific treatment of cough and paradoxical vocal fold movement
Tóm tắt
Chronic persistent cough can be associated with laryngeal dysfunction that leads to symptoms such as dysphonia, sensory hyperresponsiveness to capsaicin, and motor dysfunction with paradoxical vocal fold movement and variable extrathoracic airflow obstruction (reduced inspiratory airflow). Successful therapy of chronic persistent cough improves symptoms and sensory hyperresponsiveness. The effects of treatment for chronic cough on laryngeal dysfunction are not known. The aim of this study was to investigate effects of therapy for chronic cough and paradoxical vocal fold movement. Adults with chronic cough (n = 24) were assessed before and after treatment for chronic persistent cough by measuring quality of life, extrathoracic airway hyperresponsiveness to hypertonic saline provocation, capsaicin cough reflex hypersensitivity and fibreoptic laryngoscopy to observe paradoxical vocal fold movement. Subjects with chronic cough were classified into those with (n = 14) or without (n = 10) paradoxical vocal fold movement based on direct observation at laryngoscopy. Following treatment there was a significant improvement in cough related quality of life and cough reflex sensitivity in both groups. Subjects with chronic cough and paradoxical vocal fold movement also had additional improvements in extrathoracic airway hyperresponsiveness and paradoxical vocal fold movement. The degree of improvement in cough reflex sensitivity correlated with the improvement in extrathoracic airway hyperresponsiveness. Laryngeal dysfunction is common in chronic persistent cough, where it is manifest as paradoxical vocal fold movement and extrathoracic airway hyperresponsiveness. Successful treatment for chronic persistent cough leads to improvements in these features of laryngeal dysfunction.
Tài liệu tham khảo
Everett CF, Kastelik JA, Thompson RH, Morice AH: Chronic persistent cough in the community: a questionnaire survey. Cough. 2007, 3: 5-10.1186/1745-9974-3-5.
Vertigan A, Theodoros D, Gibson P, Winkworth A: Voice and upper airway symptoms in people with chronic cough and paradoxical vocal fold movement. J Voice. 2007, 21: 361-383. 10.1016/j.jvoice.2005.12.008.
Prudon B, Birring SS, Vara DD, Hall AP, Thompson JP, Pavord ID: Cough and glottic-stop reflex sensitivity in health and disease. Chest. 2005, 127: 550-557. 10.1378/chest.127.2.550.
Bucca C, Rolla G, Scappaticci E, Baldi S, Caria E, Oliva A: Histamine hyperresponsiveness of the extrathoracic airway in patients with asthmatic symptoms. Allergy. 1991, 46: 147-153. 10.1111/j.1398-9995.1991.tb00559.x.
Bucca C, Rolla G, Scappaticci E, Chiampo F, Bugiani M, Magnano M, D'Alberto M: Extrathoracic and intrathoracic airway responsiveness in sinusitis. J Allergy Clin Immunol. 1995, 95: 52-59. 10.1016/S0091-6749(95)70152-4.
Vertigan AE, Theodoros DG, Gibson PG, Winkworth AL: Efficacy of speech pathology management for chronic cough: a randomised placebo controlled trial of treatment efficacy. Thorax. 2006, 61: 1065-1069. 10.1136/thx.2006.064337.
Vertigan AE, Theodoros DG, Gibson PG, Winkworth AL: The relationship between chronic cough and paradoxical vocal fold movement: A review of the literature. Journal of Voice. 2006, 20: 466-480. 10.1016/j.jvoice.2005.08.001.
Murry T, Tabaee A, Aviv J: Respiratory retraining of refractory cough and laryngopharyngeal reflux in patients with paradoxical vocal fold movement disorder. The Laryngoscope. 2004, 114 (8): 1341-1345. 10.1097/00005537-200408000-00005.
Vertigan AE, Theodoras DG, Winkworth AL, Gibson PG: A comparison of two approaches to the treatment of chronic cough: perceptual, acoustic, and electroglotographic outcomes. J Voice. 2008, 22 (5): 581-589. 10.1016/j.jvoice.2007.01.001.
Birring SS, Prudon B, Carr AJ, Singh SJ, Morgan MDL, Pavord ID: Development of a symptom specific health status measure for patients with chronic cough: Leicester Cough Questionnaire. Thorax. 2003, 58: 339-343. 10.1136/thorax.58.4.339.
Locke GR, Talley NJ, Weaver AL, Zinsmeister AR: A New Questionnaire for Gastroesophageal Reflux Disease. Mayo Clinical Procedures. 1994, 69: 539-547.
Ware JEJ, Sherbourne CD: The MOS 36-item short-form health survey (SF-36). I. Conceptual framework and item selection. Med Care. 1992, 30: 473-483. 10.1097/00005650-199206000-00002.
Powell GH, Ryan NM, Taramarcaz P, Gibson PG: Development and validation of a vocal cord dysfunction questionnaire [abstract]. Respirology. 2007, 12 (Suppl 1): A39-
Irving JM, Clark EC, Crombie IK, Smith WCS: Evaluation of a portable measure of expired-air carbon monoxide. Preventive Medicine. 1988, 17: 109-115. 10.1016/0091-7435(88)90076-X.
Jarvis MJ, Tunstall-Pedoe H, Feyerabend C, Vesey C, Saloojee Y: Comparison of tests used to distinguish smokers from nonsmokers. American Journal of Public Health. 1987, 77: 1435-1438. 10.2105/AJPH.77.11.1435.
ATS/ERS: ATS/ERS Recommendations for Standardized Procedures for the Online and Offline Measurement of Exhaled Lower Respiratory Nitric Oxide and Nasal Nitric Oxide. Am J Respir Crit Care Med. 2005, 171: 912-930. 10.1164/rccm.200406-710ST.
Dicpinigaitis PV: Short- and long-term reproducibility of capsaicin cough challenge testing. Pulm Pharmacol & Therapeutics. 2003, 16: 61-65. 10.1016/S1094-5539(02)00149-9.
Birring SS, Matos S, Patel RB, Prudon B, Evans DH, Pavord ID: Cough frequency, cough sensitivity and health status in patients with chronic cough. Respir Med. 2006, 100: 1105-1109. 10.1016/j.rmed.2005.09.023.
Paggiaro PL, Chanez P, Holz O, Ind PW, Djukanovic R, Maestrelli P, Sterk PJ: Sputum induction. Eur Respir J. 2002, 20 (supplement 37): 3s-8s. 10.1183/09031936.02.00000302.
Anderson S, Gibson PG: The use of aerosols of hypertonic saline and distilled water (fog) for the patient with asthma. Asthma. Edited by: Barnes P, Grunstein M, Leff A, Woolcock A. 1997, New York, NY: Raven Press, 1135-1149.
Gibson PG, Taramarcaz P, Borgas T: Evaluation of diagnostic tests for vocal cord dysfunction. Amer J Resp Crit Care Med. 2004, 169: A317-
Kastelik JA, Aziz I, Ojoo JC, Thompson RH, Redington AE, Morice AH: Investigation and management of chronic cough using a probability-based algorithm. Eur Respir J. 2005, 25: 235-243. 10.1183/09031936.05.00140803.
Pavord ID, Chung KF: Management of chronic cough. Lancet. 2008, 371: 1375-1384. 10.1016/S0140-6736(08)60596-6.
Taramarcaz P, Grissell TV, Borgas T, Gibson PG: Transient postviral vocal cord dysfunction. J Allergy Clin Immunol. 2004, 114: 1471-1472. 10.1016/j.jaci.2004.08.038.
Birring SS, Ing AJ, Chan K, Cossa G, Matos S, Morgan MDL, Pavord ID: Obstructive sleep apnoea: a cause of chronic cough. Cough. 2007, 3: 7-10.1186/1745-9974-3-7.
Riedler J, Reade T, Dalton M, Holst D, Robertson C: Hypertonic saline challenge in an epidemiologic survey of asthma in children. Am J Respir Crit Care Med. 1994, 150: 1632-1639.
Decalmer SC, Webster D, Alice Kelsall A, McGuinness K, Woodcock AA, Smith JA: Chronic cough: how do cough reflex sensitivity and subjective assessments correlate with objective cough counts during ambulatory monitoring. Thorax. 2007, 62: 329-334. 10.1136/thx.2006.067413.
Nieto L, De Diego A, Perpina L, Compte L, Garrigues V, Martinez E, Ponce J: Cough reflex testing with inhaled capsaicin in the study of chronic cough. Respir Med. 2003, 97: 393-400. 10.1053/rmed.2002.1460.