Chronic Enteropathies in Dogs: Evaluation of Risk Factors for Negative Outcome

Journal of Veterinary Internal Medicine - Tập 21 Số 4 - Trang 700-708 - 2007
Karin Allenspach1,2, Barbara Wieland3, Andrea Gröne4,2, Frédéric Gaschen5,2
1Dr Karin Allenspach is currently affiliated with the Department of Veterinary Clinical Sciences, Royal Veterinary College, University of London, North Mymms, UK.
2Small Animal Teaching Hospital of the University of Bern, Department of Veterinary Clinical Medicine, Vetsuisse Faculty, Switzerland
3Department of Veterinary Clinical Sciences, Royal Veterinary College, University of London, North Mymms, UK (Wieland)
4Dr Andrea Gröne is currently affiliated with the Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, The Netherlands.
5Dr Frederic Gaschen is currently affiliated with the Department of Veterinary Clinical Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA

Tóm tắt

Hypothesis: Certain variables that are routinely measured during the diagnostic evaluation of dogs with chronic enteropathies will be predictive for outcome and a new clinical disease activity index incorporating these variables can be applied to predict outcome of disease.Animals: Seventy dogs were entered into a sequential treatment trial with elimination diet (FR, food‐responsive group) followed by immunosuppressive treatment with steroids if no response was seen with the dietary trial alone (ST, steroidtreatment group). A 3rd group consisted of dogs with panhypoproteinemia and ascites (PLE, protein‐losing enteropathy) that were treated with immunosuppressive doses of steroids.Methods: Three years of follow‐up information was available for all dogs. Clinicopathologic variables were tested for their ability to predict negative outcome, defined as euthanasia due to refractoriness to treatment. Different scoring systems including different combinations of these variables were evaluated using receiver operating characteristic (ROC) curves.Results: Thirteen of 70 (18%) dogs were euthanized because of intractable disease. Univariate analysis identified a high clinical activity index, high endoscopic score in the duodenum, hypocobalaminemia (<200 ng/L) and hypoalbuminemia (<20 g/L) as risk factors for negative outcome.Conclusions and Clinical Importance: Based on the factors identified by logistic regression and ROC curve analysis, a new clinical scoring index (CCECAI) was defined that predicts negative outcome in dogs suffering from chronic enteropathies.

Từ khóa


Tài liệu tham khảo

Jergens AE, 1992, Idiopathic inflammatory bowel disease in dogs and cats: 84 Cases (1987–1990), J Am Vet Med Assoc, 201, 1603, 10.2460/javma.1992.201.10.1603

10.1111/j.1939-1676.2003.tb01318.x

Hall E., 2005, Textbook of Veterinary Internal Medicine, 1332

10.1016/S0195-5616(99)50032-6

10.1111/j.1748-5827.2004.tb00245.x

10.1111/j.1939-1676.2003.tb02450.x

10.1111/j.1939-1676.2006.tb02849.x

Jergens AE, 1992, Idiopathic inflammatory bowel disease in dogs and cats: 84 Cases (1987–1990), J Am Vet Med Assoc, 201, 1603, 10.2460/javma.1992.201.10.1603

10.1136/vr.154.17.519

10.2460/javma.2000.217.703

10.2460/javma.2002.220.1177

10.1111/j.1939-1676.2001.tb02293.x

10.1111/j.1939-1676.2005.tb02676.x

10.1111/j.1939-1676.2003.tb01321.x

Simpson KW, 1989, Effect of exocrine pancreatic insufficiency on cobalamin absorption in dogs, Am J Vet Res, 50, 1233

Batt RM, 1991, Role of the pancreas in the absorption and malabsorption of cobalamin (vitamin B‐12) in dogs, J Nutr, 121, S75, 10.1093/jn/121.suppl_11.S75

Thông tin
Thông tin xuất bản

Journal of Veterinary Internal Medicine

Tập 21 Số 4

700-708

Thông tin tác giả