Chiral Brønsted Acid‐Mediated Enantioselective Organocatalytic Three‐Component Reaction for the Construction of Trifluoromethyl‐Containing Molecules
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Tài liệu tham khảo
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A mixture of indole (43.8 mg 0.37 mmol) trifluoroacetaldehyde methyl hemiacetal (48.8 mg 0.37 mmol) Brønsted acid1h(0.025 mmol) and powdered 4 Å molecular sieves (50 mg) in toluene (1.0 mL) was stirred at room temperature for 96 h. No reaction occurred. When the reaction mixture was stirred at 80 °C for 72 h the hydroxyalkylated indole was obtained in 87% yield with a 3%eevalue.
CCDC 672342 contains the supplementary crystallographic data for this paper. These data can be obtained free of charge from The Cambridge Crystallographic Data Centreviawww.ccdc.cam.ac.uk/data_request/cif.