Chimeric antigen receptor T cells secreting anti-PD-L1 antibodies more effectively regress renal cell carcinoma in a humanized mouse model

Oncotarget - Tập 7 Số 23 - Trang 34341-34355 - 2016
Eloah Rabello Suarez1,2,3, De Kuan Chang2,3, Jiusong Sun2,3, Jianhua Sui4, Gordon J. Freeman5,3, Sabina Signoretti6, Quan Zhu2,3, Wayne A. Marasco2,3
1Department of Biochemistry, Faculdade de Medicina do ABC, Av. Príncipe de Gales, SP, Brazil
2Department of Cancer Immunology and Virology, Dana-Farber Cancer Institute (DFCI), Boston, MA, USA
3Department of Medicine, Harvard Medical School, Boston, MA USA
4National Institute of Biological Sciences, ZGC Life Science Park, Changping, Beijing, China
5Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA, USA
6Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, USA

Tóm tắt

Từ khóa


Tài liệu tham khảo

Thompson, 2001, T-cell regulation by CD28 and CTLA-4, Nat Rev Immunol, 1, 220, 10.1038/35105024

Carter, 2000, Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation, J Exp Med, 192, 1027, 10.1084/jem.192.7.1027

Pardoll, 2012, The blockade of immune checkpoints in cancer immunotherapy, Nat Rev Cancer, 12, 252, 10.1038/nrc3239

Bhatia, 2012, Safety and activity of anti-PD-L1 antibody in patients with advanced cancer, N Engl J Med, 366, 2455, 10.1056/NEJMoa1200694

Hegde, 2014, MPDL3280A (anti-PD-L1) treatment leads to clinical activity in metastatic bladder cancer, Nature, 515, 558, 10.1038/nature13904

Gore, 2015, Immunotherapies in Early and Advanced Renal Cell Cancer, Prog Tumor Res, 42, 1, 10.1159/000436988

Choueiri, 2014, PD-1 blockade in renal cell carcinoma: to equilibrium and beyond, Cancer Immunol Res, 2, 1132, 10.1158/2326-6066.CIR-14-0193

Grupp, 2012, The future is now: chimeric antigen receptors as new targeted therapies for childhood cancer, Clin Cancer Res, 18, 2780, 10.1158/1078-0432.CCR-11-1920

Sadelain, 2002, Human T-lymphocyte cytotoxicity and proliferation directed by a single chimeric TCRzeta /CD28 receptor, Nat Biotechnol, 20, 70, 10.1038/nbt0102-70

Riddell, 2015, Engineering CAR-T cells: Design concepts, Trends Immunol, 36, 494, 10.1016/j.it.2015.06.004

Rheingold, 2014, Chimeric antigen receptor T cells for sustained remissions in leukemia, N Engl J Med, 371, 1507, 10.1056/NEJMoa1407222

Huang, 2016, Anti-CD19 chimeric antigen receptor-modified T cells for B-cell malignancies: a systematic review of efficacy and safety in clinical trials, Eur J Haematol, 96, 389, 10.1111/ejh.12602

Gottschalk, 2014, CAR T cells for solid tumors: armed and ready to go?, Cancer J, 20, 151, 10.1097/PPO.0000000000000032

Pastorekova, 2014, Carbonic anhydrase IX, a hypoxia-induced catalytic component of the pH regulating machinery in tumors, Front Physiol, 4, 400

Pastorek, 2014, Carbonic anhydrase IX: regulation and role in cancer, Subcell Biochem, 75, 199, 10.1007/978-94-007-7359-2_11

Gigante, 2010, Carbonic anhydrase 9 in clear cell renal cell carcinoma: a marker for diagnosis, prognosis and treatment, Eur J Cancer, 46, 3141, 10.1016/j.ejca.2010.07.020

Signoretti, 2010, Carbonic anhydrase IX expression in renal neoplasms: correlation with tumor type and grade, Am J Clin Pathol, 134, 873, 10.1309/AJCPPPR57HNJMSLZ

Cooper, 2011, Reprogramming CD19-specific T cells with IL-21 signaling can improve adoptive immunotherapy of B-lineage malignancies, Cancer Res, 71, 3516, 10.1158/0008-5472.CAN-10-3843

Restifo, 2008, IL-2 and IL-21 confer opposing differentiation programs to CD8+ T cells for adoptive immunotherapy, Blood, 111, 5326, 10.1182/blood-2007-09-113050

Marasco, 2014, Regression of established renal cell carcinoma in nude mice using lentivirus-transduced human T-cells expressing a human anti-CAIX chimeric antigen receptor, Mol Ther Oncolytics, 1, 1

Freeman, 2015, PD-L1 Antibodies to Its Cytoplasmic Domain Most Clearly Delineate Cell Membranes in Immunohistochemical Staining of Tumor Cells, Cancer Immunol Res, 3, 1308, 10.1158/2326-6066.CIR-15-0116

Tamada, 2015, Immune checkpoint blockade opens an avenue of cancer immunotherapy with a potent clinical efficacy, Cancer Sci, 106, 945, 10.1111/cas.12695

Mulligan, 2006, Exogenous control of mammalian gene expression via modulation of translational termination, Nat Med, 12, 1093, 10.1038/nm1376

Liu, 2015, Clinicopathological and prognostic value of programmed death ligand-1 (PD-L1) in renal cell carcinoma: a meta-analysis, Int J Clin Exp Med, 8, 14595

Freeman, 2007, The function of programmed cell death 1 and its ligands in regulating autoimmunity and infection, Nat Immunol, 8, 239, 10.1038/ni1443

Sharpe, 2008, PD-1 and its ligands in tolerance and immunity, Annu Rev Immunol, 26, 677, 10.1146/annurev.immunol.26.021607.090331

Rosenberg, 2007, Ipilimumab (anti-CTLA4 antibody) causes regression of metastatic renal cell cancer associated with enteritis and hypophysitis, J Immunother, 30, 825, 10.1097/CJI.0b013e318156e47e

Antonia, 2012, Safety, activity, and immune correlates of anti-PD-1 antibody in cancer, N Engl J Med, 366, 2443, 10.1056/NEJMoa1200690

Parren, 2012, Crosstalk between human IgG isotypes and murine effector cells, J Immunol, 189, 3430, 10.4049/jimmunol.1200356

Dong, 2011, B7-h1 expressed by activated CD8 T cells is essential for their survival, J Immunol, 187, 5606, 10.4049/jimmunol.1003976

Marasco, 2015, Human anti-CAIX antibodies mediate immune cell inhibition of renal cell carcinomaand in a humanized mouse model, Mol Cancer, 14, 119, 10.1186/s12943-015-0384-3

Chen, 2004, NK and CD8+ T cell-mediated eradication of poorly immunogenic B16-F10 melanoma by the combined action of IL-12 gene therapy and 4-1BB costimulation, Int J Cancer, 109, 499, 10.1002/ijc.11696

Dhodapkar, 2015, Combination therapy with anti-CTLA-4 and anti-PD-1 leads to distinct immunologic changes, J Immunol, 194, 950, 10.4049/jimmunol.1401686

Patsch, 2015, Radiation and dual checkpoint blockade activate non-redundant immune mechanisms in cancer, Nature, 520, 373, 10.1038/nature14292

Kronenberg, 2013, Nivolumab plus ipilimumab in advanced melanoma, N Engl J Med, 369, 122, 10.1056/NEJMoa1302369

Darcy, 2013, Anti-PD-1 antibody therapy potently enhances the eradication of established tumors by gene-modified T cells, Clin Cancer Res, 19, 5636, 10.1158/1078-0432.CCR-13-0458

Wolchok, 2015, Toxicities of the anti-PD-1 and anti-PD-L1 immune checkpoint antibodies, Ann Oncol, 26, 2375, 10.1093/annonc/mdv383

Gratama, 2013, Treatment of metastatic renal cell carcinoma with CAIX CAR-engineered T cells: clinical evaluation and management of on-target toxicity, Mol Ther, 21, 904, 10.1038/mt.2013.17

Gratama, 2007, Gene-modified T cells for adoptive immunotherapy of renal cell cancer maintain transgene-specific immune functions, Cancer Immunol Immunother, 56, 1875, 10.1007/s00262-007-0330-3

Gratama, 2011, Immune responses to transgene and retroviral vector in patients treated with-engineered T cells, Blood, 117, 72, 10.1182/blood-2010-07-294520

Fry, 2015, 4-1BB costimulation ameliorates T cell exhaustion induced by tonic signaling of chimeric antigen receptors, Nat Med, 21, 581, 10.1038/nm.3838

Marasco, 2010, Unique biological properties of catalytic domain directed human anti-CAIX antibodies discovered through phage-display technology, PLoS One, 5, e9625, 10.1371/journal.pone.0009625

Sodroski, 2000, Paramagnetic proteoliposomes containing a pure, native, and oriented seven-transmembrane segment protein, CCR5, Nat Biotechnol, 18, 649, 10.1038/76501

Salfeld, 2007, Isotype selection in antibody engineering, Nat Biotechnol, 25, 1369, 10.1038/nbt1207-1369

Uludag, 2012, A simple and rapid nonviral approach to efficiently transfect primary tissue-derived cells using polyethylenimine, Nat Protoc, 7, 935, 10.1038/nprot.2012.038

Kupper, 2012, Humanization of an anti-CCR4 antibody that kills cutaneous T-cell lymphoma cells and abrogates suppression by T-regulatory cells, Mol Cancer Ther, 11, 2451, 10.1158/1535-7163.MCT-12-0278

De, 2014, IHC Profiler: an open source plugin for the quantitative evaluation and automated scoring of immunohistochemistry images of human tissue samples, PLoS One, 9, e96801, 10.1371/journal.pone.0096801