Chilblains in children in the setting of COVID‐19 pandemic

Pediatric Dermatology - Tập 37 Số 3 - Trang 406-411 - 2020
David Andina Martínez1, Lucero Noguera‐Morel2, Marta Bascuas‐Arribas1, Jara Gaitero‐Tristán1, José Antonio Alonso‐Cadenas1, Silvia Escalada Pellitero1, Á. Hernández‐Martín2, Mercedes de la Torre‐Espi1, Isabel Colmenero3, Antonio Torrelo2
1Emergency Department, Hospital Infantil Universitario Niño Jesús, Madrid, Spain
2Department of Dermatology Hospital Infantil Universitario Niño Jesús Madrid Spain
3Department of Pathology, Hospital Infantil Universitario Niño Jesús, Madrid, Spain

Tóm tắt

AbstractBackgroundDifferent skin manifestations of COVID‐19 are being reported. Acral lesions on the hands and feet, closely resembling chilblains, have been recognized during the peak incidence of the COVID‐19 pandemic.Material and methodsA retrospective review of 22 children and adolescents with chilblain‐like lesions seen over a short period of time in the Emergency Department of a children's hospital during the peak incidence of COVID‐19 in Madrid, Spain.ResultsAll patients had lesions clinically consistent with chilblains of the toes or feet, with three also having lesions of the fingers. Pruritus and mild pain were the only skin symptoms elicited, and only 10 had mild respiratory and/or GI symptoms. None had fever. Coagulation tests, hemogram, serum chemistry, and lupus anticoagulant were normal in all patients tested. One out of 16 tested cases had elevated D‐dimer results, but without systemic symptoms or other laboratory anomalies. SARS‐CoV‐2 PCR tested in 19 cases was positive in just one case. Skin biopsies obtained in six patients were consistent with chilblains. On follow‐up, all cases showed spontaneous marked improvement or complete healing.ConclusionAcute chilblains were observed during COVID‐19 pandemic in children and teenagers. It is a mildly symptomatic condition with an excellent prognosis, usually requiring no therapy. Etiopathogenesis remains unknown.

Từ khóa


Tài liệu tham khảo

10.1111/jdv.16387

10.1111/jdv.16471

Marzano AV, 2020, Varicella‐like exanthem as a specific COVID‐19‐associated skin manifestation: multicenter case series of 22 patients, J Am Acad Dermatol, S0190‐9622(20)3

10.1111/jdv.16472

Manalo IF, 2020, A dermatologic manifestation of COVID‐19: transient livedo reticularis, J Am Acad Dermatol, S0190‐9622(20)3

Zhang Y, 2020, Clinical and coagulation characteristics of 7 patients with critical COVID‐2019 pneumonia and acro‐ischemia, Zhonghua Xue Ye Xue Za Zhi, 41, E006

Mazzotta F, 2020, Acute acro‐ischemia in the child at the time of COVID‐19, Eur J Pediatr Dermatol

Tagarro A, 2020, Screening and severity of coronavirus disease 2019 (COVID‐19) in children in Madrid, Spain, JAMA Pediatr, e201346

10.1024/0301-1526/a000838

10.1016/j.mayocp.2013.09.020

10.1067/mjd.2001.117861

10.1542/peds.2004-2681

10.1177/0009922809355314

10.1046/j.1525-1470.2000.01722.x

10.1111/j.1365-2133.2010.09829.x

10.1111/ced.13621

10.1016/j.jaad.2009.11.010

10.1097/RHU.0b013e3181639aaa

10.1097/DAD.0000000000000945

10.1097/00005792-200105000-00004

10.1111/j.1600-0560.2007.00900.x

10.1007/s00109-016-1465-5

Zhou Z, 2020, Overly exuberant innate immune response to SARS‐CoV‐2 infection, SSRN Electron J

10.1016/j.jdcr.2020.04.011

10.1159/000437224

10.1001/archderm.143.2.274

Gutiérrez‐Ortiz C, 2020, Miller Fisher syndrome and polyneuritis cranialis in COVID‐19, Neurology, 10.1212/