Chemotherapeutic effects of luteolin on radio-sensitivity enhancement and interleukin-6/signal transducer and activator of transcription 3 signaling repression of oral cancer stem cells

Visvader, 2008, Cancer stem cells in solid tumours: accumulating evidence and unresolved questions, Nat Rev Cancer, 8, 755, 10.1038/nrc2499 Hu, 2012, Impairment of tumor-initiating stem-like property and reversal of epithelial–mesenchymal transdifferentiation in head and neck cancer by resveratrol treatment, Mol Nutr Food Res, 56, 1247, 10.1002/mnfr.201200150 Yu, 2013, miR145 targets the SOX9/ADAM17 axis to inhibit tumor-initiating cells and IL-6-mediated paracrine effects in head and neck cancer, Cancer Res, 73, 3425, 10.1158/0008-5472.CAN-12-3840 Liu, 2016, Sulforaphane targets cancer stemness and tumor initiating properties in oral squamous cell carcinomas via miR-200c induction, J Formos Med Assoc Yu, 2016, Suppression of miR-204 enables oral squamous cell carcinomas to promote cancer stemness, EMT traits, and lymph node metastasis, Oncotarget, 7, 20180, 10.18632/oncotarget.7745 Chiou, 2008, Positive correlations of Oct-4 and Nanog in oral cancer stem-like cells and high-grade oral squamous cell carcinoma, Clin Cancer Res, 14, 4085, 10.1158/1078-0432.CCR-07-4404 Chen, 2011, CD133/Src axis mediates tumor initiating property and epithelial–mesenchymal transition of head and neck cancer, PLoS One, 6, e28053, 10.1371/journal.pone.0028053 Wu, 2010, Elimination of head and neck cancer initiating cells through targeting glucose regulated protein78 signaling, Mol Cancer, 9, 283, 10.1186/1476-4598-9-283 Yu, 2016, Targeting CD133 in the enhancement of chemosensitivity in oral squamous cell carcinoma-derived side population cancer stem cells, Head Neck, 38, E231, 10.1002/hed.23975 Lin, 2008, Luteolin, a flavonoid with potential for cancer prevention and therapy, Curr Cancer Drug Targets, 8, 634, 10.2174/156800908786241050 Ding, 2014, Anti-hepatoma cells function of luteolin through inducing apoptosis and cell cycle arrest, Tumour Biol, 35, 3053, 10.1007/s13277-013-1396-5 Cai, 2011, Luteolin induced G2 phase cell cycle arrest and apoptosis on non-small cell lung cancer cells, Toxicol In Vitro, 25, 1385, 10.1016/j.tiv.2011.05.009 Chang, 2005, Increase of Bax/Bcl-XL ratio and arrest of cell cycle by luteolin in immortalized human hepatoma cell line, Life Sci, 76, 1883, 10.1016/j.lfs.2004.11.003 Chian, 2014, Luteolin inhibits the Nrf2 signaling pathway and tumor growth in vivo, Biochem Biophys Res Commun, 447, 602, 10.1016/j.bbrc.2014.04.039 Ju, 2007, A critical role of luteolin-induced reactive oxygen species in blockage of tumor necrosis factor-activated nuclear factor-kappaB pathway and sensitization of apoptosis in lung cancer cells, Mol Pharmacol, 71, 1381, 10.1124/mol.106.032185 Rao, 2012, Luteolin induces apoptosis in multidrug resistant cancer cells without affecting the drug transporter function: involvement of cell line-specific apoptotic mechanisms, Int J Cancer, 130, 2703, 10.1002/ijc.26308 Choi, 2010, Luteolin suppresses IL-1beta-induced cytokines and MMPs production via p38 MAPK, JNK, NF-kappaB and AP-1 activation in human synovial sarcoma cell line, SW982, Food Chem Toxicol, 48, 2607, 10.1016/j.fct.2010.06.029 Dia, 2016, Epithelial-to-mesenchymal transition in paclitaxel-resistant ovarian cancer cells is downregulated by luteolin, J Cell Physiol Ruan, 2012, Inhibition of hypoxia-induced epithelial mesenchymal transition by luteolin in non-small cell lung cancer cells, Mol Med Rep, 6, 232 Tsai, 2014, Oct4 mediates tumor initiating properties in oral squamous cell carcinomas through the regulation of epithelial–mesenchymal transition, PLoS One, 9, e87207, 10.1371/journal.pone.0087207 Kumar, 2014, Silibinin strongly inhibits the growth kinetics of colon cancer stem cell-enriched spheroids by modulating interleukin 4/6-mediated survival signals, Oncotarget, 5, 4972, 10.18632/oncotarget.2068 Chou, 2015, Sox2 expression involvement in the oncogenicity and radiochemoresistance of oral cancer stem cells, Oral Oncol, 51, 31, 10.1016/j.oraloncology.2014.10.002 Chen, 2010, Cucurbitacin I suppressed stem-like property and enhanced radiation-induced apoptosis in head and neck squamous carcinoma-derived CD44(+)ALDH1(+) cells, Mol Cancer Ther, 9, 2879, 10.1158/1535-7163.MCT-10-0504 Li, 2015, Molecular and cellular cues of diet-associated oral carcinogenesis-with an emphasis on areca-nut-induced oral cancer development, J Oral Pathol Med, 44, 167, 10.1111/jop.12171 Yu, 2011, MicroRNA let-7a represses chemoresistance and tumourigenicity in head and neck cancer via stem-like properties ablation, Oral Oncol, 47, 202, 10.1016/j.oraloncology.2010.12.001 Bowman, 2000, STATs in oncogenesis, Oncogene, 19, 2474, 10.1038/sj.onc.1203527 Bromberg, 2002, Stat proteins and oncogenesis, J Clin Invest, 109, 1139, 10.1172/JCI0215617 Leeman-Neill, 2011, Inhibition of EGFR-STAT3 signaling with erlotinib prevents carcinogenesis in a chemically-induced mouse model of oral squamous cell carcinoma, Cancer Prev Res (Phila), 4, 230, 10.1158/1940-6207.CAPR-10-0249 Macha, 2011, Prognostic significance of nuclear pSTAT3 in oral cancer, Head Neck, 33, 482, 10.1002/hed.21468 Tang, 2008, Progenitor/stem cells give rise to liver cancer due to aberrant TGF-beta and IL-6 signaling, Proc Natl Acad Sci U S A, 105, 2445, 10.1073/pnas.0705395105 Marotta, 2011, The JAK2/STAT3 signaling pathway is required for growth of CD44(+)CD24(−) stem cell-like breast cancer cells in human tumors, J Clin Invest, 121, 2723, 10.1172/JCI44745 Korkaya, 2011, Breast cancer stem cells, cytokine networks, and the tumor microenvironment, J Clin Invest, 121, 3804, 10.1172/JCI57099 Korkaya, 2012, Activation of an IL6 inflammatory loop mediates trastuzumab resistance in HER2+ breast cancer by expanding the cancer stem cell population, Mol Cell, 47, 570, 10.1016/j.molcel.2012.06.014 Chen, 2010, Significance of interleukin-6 signaling in the resistance of pharyngeal cancer to irradiation and the epidermal growth factor receptor inhibitor, Int J Radiat Oncol Biol Phys, 76, 1214, 10.1016/j.ijrobp.2009.09.059