Chemoprophylaxis of colon cancer
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Reddy BS, Patlolla JM, Simi B, et al.: Prevention of colon cancer by low doses of celecoxib, a cyclooxygenase as inhibitor, administered in diet rich in omega-3 polyunsaturated fatty acids. Cancer Res 2005, in press. The results strongly indicate that very low, low, and moderately low levels of celecoxib administered in diets containing saturated fats or omega-3 fatty acids (ω-3 PUFAs) suppressed colon carcinogenesis. More importantly, the inhibition of colon adenocarcinomas was more pronounced in animals given very low doses of celecoxib in ω-3 PUFAs as compared with the effects of very low dose celecoxib given in a saturated fat diet.