Chemoprevention of oral carcinogenesis

Foulds, 1954, The experimental study of tumor progression: a review, Cancer Res, 14, 327 Sugimura, 1992, Multiple genetic alterations in human carcinogenesis, Environ Health Perspect, 98, 5, 10.1289/ehp.92985 Parkin, 1988, Estimates of the worldwide frequency of sixteen major cancers, Int J Cancer, 41, 184, 10.1002/ijc.2910410205 Parkin, 1993, Estimates of the worldwide incidence of eighteen major cancers in 1985, Int J Cancer, 54, 594, 10.1002/ijc.2910540413 MacFarlane, 1987, Rising mortality from cancer of the tongue in young Scottish males, Lancet, 2, 912, 10.1016/S0140-6736(87)91394-8 Dunham, 1968, A geographic study of a relationship between oral cancer and plants, Cancer Res, 28, 2369 Baden, 1968, Tobacco and oropharyngeal and bronchial cancer, Rev Med Toulouse, 14, 549 Muir, 1960, Betel, tobacco and cancer of the mouth, Br J Cancer, 14, 597, 10.1038/bjc.1960.65 Blot, 1988, Smoking and drinking in relation to oral and pharyngeal cancer, Cancer Res, 48, 3282 Davis, 1987, Increasing incidence of cancer of the tongue in the US among young adults, Lancet, 2, 910, 10.1016/S0140-6736(87)91393-6 Boring, 1992, Cancer Statistics, 1992, CA Cancer J Clin, 42, 19, 10.3322/canjclin.42.1.19 Health Welfare Statistics Association, 1993, J Health Welfare Statistics, 40, 29 Uecchia, 1993, Trends in cancer mortality, 1955–1989: Asia, Africa and Oceania, Eur J Cancer, 29A, 2168, 10.1016/0959-8049(93)90057-M Sankaranarayanan, 1990, Oral cancer in India: an epidemiologic and clinical review, Oral Surg Oral Med Oral Pathol, 69, 325, 10.1016/0030-4220(90)90294-3 Smith, 1989, Oral cancer and precancer: background, epidemiology and aetiology, Br Dent J, 167, 377, 10.1038/sj.bdj.4807055 Herity, 1981, A case—control study of head and neck cancer in the Republic of Ireland, Br J Cancer, 43, 177, 10.1038/bjc.1981.26 Leclerc, 1987, Type of alcoholic beverage and cancer of the upper respiratory and digestive tract, Eur J Cancer Clin Oncol, 23, 529, 10.1016/0277-5379(87)90315-4 Nachiappan, 1993, Ethanol-mediated promotion of oral carcinogenesis in hamsters: association with lipid peroxidation, Nutr Cancer, 20, 293, 10.1080/01635589309514297 Cox, 1991, Viruses in the etiology of oral carcinoma? Examination of the evidence, Br J Oral Maxillofac Surg, 29, 381, 10.1016/0266-4356(91)90006-Q Eskinazi, 1987, Oncogenic potential of sexually transmitted viruses with special reference to oral cancer, Oral Surg Oral Med Oral Pathol, 64, 35, 10.1016/0030-4220(87)90113-7 Hecht, 1989, The relevance of tobacco-specific nitrosamines to human cancer, Cancer Surv, 8, 273 Felton, 1990, Heterocyclic amine mutagens/carcinogens in food, 471 Ng, 1993, Oral cavity cancer in non-users of tobacco, J Natl Cancer Inst, 85, 743, 10.1093/jnci/85.9.743 WHO Collaborating Centre for Oral Precancerous Lesions, 1978, Definition of leukoplakia and related lesions: an aid to studies on oral precancer, Oral Surg Oral Med Oral Pathol, 46, 518, 10.1016/0030-4220(78)90383-3 Bánóczy, 1976, Occurrence of epithelial dysplasia in oral leukoplakia: analysis and follow-up study of 12 cases, Oral Surg Oral Med Oral Pathol, 42, 766, 10.1016/0030-4220(76)90099-2 Tanaka, 1991, Alterations of the nucleolar organizer regions during 4-nitroqui-noline 1-oxide-induced tongue carcinogenesis in rats, Carcinogenesis, 12, 329, 10.1093/carcin/12.2.329 Lippman, 1989, Second primary tumors in head and neck squamous cell carcinoma : the overshadowing threat for patients with early-stage disease, Int J Radiat Oncol Biol Phys, 17, 691, 10.1016/0360-3016(89)90126-0 Kotwall, 1989, Multiple primary cancers in squamous cell cancer of the head and neck, J Surg Oncol, 40, 97, 10.1002/jso.2930400208 Day, 1992, Second primary tumors in patients with oral cancer, Cancer, 70, 14, 10.1002/1097-0142(19920701)70:1<14::AID-CNCR2820700103>3.0.CO;2-S Jovanovic, 1994, Risk of multiple primary tumors following oral squamous-cell carcinoma, Int J Cancer, 56, 320, 10.1002/ijc.2910560304 Garewal, 1991, Potential role of β-carotene in prevention of oral cancer, Am J Clin Nutr, 53, 294S, 10.1093/ajcn/53.1.294S Slaughter, 1953, “Field cancerization” in oral stratified squamous cell epithelium : clinical implications of multicentric origin, Cancer, 5, 963, 10.1002/1097-0142(195309)6:5<963::AID-CNCR2820060515>3.0.CO;2-Q Weinberg, 1989, Oncogenes, antioncogenes and the molecular basis of multistep carcinogenesis, Cancer Res, 49, 3713 Franco, 1989, Risk factors for oral cancer in Brazil: a case—control study, Int J Cancer, 43, 992, 10.1002/ijc.2910430607 Hebert, 1993, Consumption of meat and fruit in relation to oral and esophageal cancer: a cross-national study, Nutr Cancer, 19, 169, 10.1080/01635589309514247 Notani, 1987, Role of diet in upper aerodigestive tract cancers, Nutr Cancer, 10, 103, 10.1080/01635588709513945 Rossing, 1989, Diet and pharyngeal cancer, Int J Cancer, 44, 593, 10.1002/ijc.2910440406 Winn, 1984, Diet in the etiology of oral and pharyngeal cancer among women from the Southern U.S., Cancer Res, 44, 1216 Graham, 1981, Dietary factors in the epidemiology of cancer of the larynx, Am J Epidemiol, 113, 575, 10.1093/oxfordjournals.aje.a113147 Ziegler, 1989, A review of epidemiologic evidence that carotenoids reduce the risk of cancer, J Nutr, 119, 116, 10.1093/jn/119.1.116 McLaughlin, 1988, Dietary factors in oral and pharyngeal cancer, J Natl Cancer Inst, 80, 1237, 10.1093/jnci/80.15.1237 Gridley, 1990, Diet and oral and pharyngeal cancer among blacks, Nutr Cancer, 14, 219, 10.1080/01635589009514096 Block, 1992, Fruit, vegetables, and cancer prevention : a review of the epidemiological evidence, Nutr Cancer, 18, 1, 10.1080/01635589209514201 Garewal, 1993, Oral cancer prevention : the case for carotenoids and anti-oxidants nutrients, Prev Med, 22, 701, 10.1006/pmed.1993.1064 Gridley, 1992, Vitamin supplement use and reduced risk of oral and pharyngeal cancer, Am J Epidemiol, 135, 1083, 10.1093/oxfordjournals.aje.a116208 Weisburger, 1991, Nutritional approach to cancer prevention with emphasis on vitamins, antioxidants, and carotenoids, Am J Clin Nutr, 53, 226S, 10.1093/ajcn/53.1.226S Scully, 1992, Viruses and oral squamous carcinoma, Oral Oncol, Eur J Cancer, 28B, 57, 10.1016/0964-1955(92)90014-R Yeudall, 1992, Human papillomaviruses and oral neoplasia, Oral Oncol, Eur J Cancer, 28B, 61, 10.1016/0964-1955(92)90015-S Krogh, 1990, The role of yeasts in oral cancer by means of endogenous nitrosation, Acta Odontol Scand, 48, 85, 10.3109/00016359009012738 Jacobs, 1990, Etiologic considerations for head and neck squamous cancers, 265 Crissman, 1989, Dysplasia, in situ carcinoma, and progression to invasive squamous cell carcinoma of the upper aerodigestive tract, Am J Surg Pathol, 13, 5 Solt, 1981, Localization of gamma-glutamyl transpeptidase in hamster buccal pouch epithelium treated with 7,12-dimethylben-z[a]anthracene, J Natl Cancer Inst, 67, 193 Solt, 1982, Rapid induction of gamma-glutamyltrans-peptidase-rich intraepithelial clones in 7,12-dimethylben-z[a]anthracene-treated hamster buccal pouch, Cancer Res, 42, 285 Odajima, 1984, Persistence of gammaglutamyltranspeptidase-positive foci during hamster buccal pouch carcinogenesis, Cancer Res, 44, 2062 Aldaz, 1988, Sequential development of aneuploidy, keratin modifications, and γ-glutamyltransferase expression in mouse skin papillomas, Cancer Res, 48, 3253 Zhang, 1987, Gamma-glutamyl transpeptidase activity during carcinogenesis of hamster buccal pouch epithelium, Carcinogenesis, 8, 977, 10.1093/carcin/8.7.977 Zhang, 1994, The value of placental glutathione S-transferase and gamma-glutamyl transpeptidase as markers of altered foci during hamster pouch carcinogenesis, Carcinogenesis, 15, 105, 10.1093/carcin/15.1.105 Shin, 1990, Expression of epidermal growth factor receptor, polyamine levels, ornithine decarboxylase activity, micronuclei and transglutaminase I in a 7,12-dimethylbenz[a]anthracene-induced hamster buccal pouch carcinogenesis model, Cancer Res, 50, 2505 Zenklusen, 1994, Transforming growth factor-β1 expression in Syrian hamster cheek pouch carcinogenesis, Mol Carcinogenesis, 9, 10, 10.1002/mc.2940090104 Moll, 1982, The catalog of human cytokeratins : patterns of expression in normal epithelia, tumors and cultured cells, Cell, 31, 11, 10.1016/0092-8674(82)90400-7 Gimenez-Conti, 1990, Changes in keratin expression during 7,12-dimethylbenz[a]anthracene-induced hamster cheek pouch carcinogenesis, Cancer Res, 50, 4441 Husain, 1989, Sequential expression and cooperative interaction of c-Ha-ras and c-erb B genes in in vivo chemical carcinogenesis, 86, 1264 Gimenez-Conti, 1992, Activating mutation of the Ha-ras gene in chemically induced tumors of the hamster cheek pouch, Mol Carcinogenesis, 5, 259, 10.1002/mc.2940050405 Wong, 1987, Expression of c-erb proto-oncogene during dimethylbenz[a]anthracene-induced tumorigenesis in hamster cheek pouch, Oncogene, 2, 67 Wong, 1987, Amplification of the c-erb B1 oncogene in chemi- cally induced oral carcinomas, Carcinogenesis, 8, 1963, 10.1093/carcin/8.12.1963 Wong, 1988, Transforming growth factor-α in chemically transformed hamster oral keratinocytes, Cancer Res, 48, 3130 Gimenez-Conti, 1993, The hamster cheek pouch carcinogenesis model, J Cell Biochem, 17F cm(suppl.), 83, 10.1002/jcb.240531012 Eveson, 1983, Oral premalignancy, Cancer Surv, 2, 403 Pillai, 1992, Pathogenesis of oral submucous fibrosis. Relationship to risk factors associated with oral cancer, Cancer, 69, 2011, 10.1002/1097-0142(19920415)69:8<2011::AID-CNCR2820690802>3.0.CO;2-B Lindberg, 1989, Suprabasal 40 kd keratin (K19) expression as an immunohistologic marker of premalignancy in oral epithelium, Am J Pathol, 134, 89 Wolf, 1988, Monoclonal antibodies as prognostic indicators in patients with squamous cancer of the oral cavity and oral pharynx, Acta Otolaryngol, 449, 229, 10.3109/00016488809106418 Tadokoro, 1989, Activation of oncogenes in human oral cancer cells: a novel codon 13 mutation of C-Ha-ras-1 and concurrent amplification of C-erbB-1 and c-myc, Oncogene, 4, 499 Partridge, 1988, Expression of epidermal growth factor receptor on oral squamous cell carcinoma, Br J Oral Maxillofac Surg, 26, 381, 10.1016/0266-4356(88)90090-3 Prime, 1987, The expression of cell surface HLA heavy and light chain molecules in premalignant and malignant lesions of the oral mucosa, Histopathology, 11, 81, 10.1111/j.1365-2559.1987.tb02611.x Field, 1987, Expression of oncogenes in human tumours with special reference to the head and neck region, J Oral Pathol, 16, 97, 10.1111/j.1600-0714.1987.tb01474.x Yamada, 1992, Evaluation of epidermal growth factor receptor in squamous cell carcinoma of the oral cavity, Oral Surg Oral Med Oral Pathol, 73, 67, 10.1016/0030-4220(92)90157-L Satoh, 1992, Immunohistochemical detection of ras 21 in oral squamous cell carcinomas, Oral Surg Oral Med Oral Pathol, 74, 469, 10.1016/0030-4220(92)90298-5 Lee, 1993, Detection of chromosomal polysomy in oral leukoplakia, a premalignant lesion, J Natl Cancer Inst, 85, 1951, 10.1093/jnci/85.23.1951 Voravud, 1993, Increased polysomies of chromosomes 7 and 17 during head and neck multistage tumorigenesis, Cancer Res, 53, 2874 Scully, 1992, Oncogenes, onco-suppressors, carcinogenesis and oral cancer, Br Dent J, 173, 53, 10.1038/sj.bdj.4807936 Field, 1992, Oncogenes and tumour-suppressor genes in squamous cell carcinoma of the head and neck, Oral Oncol, Eur J Cancer, 28B, 67, 10.1016/0964-1955(92)90016-T Sakai, 1992, Most human squamous cell carcinomas in the oral cavity contain mutated p53 tumor-suppressor genes, Oncogene, 7, 927 Ogden, 1992, Assessment of p53 protein expression in normal, benign, and malignant oral mucosa, J Pathol, 166, 389, 10.1002/path.1711660411 Shin, 1994, Activation of p53 gene expression in premalignant lesions during head and neck tumorigenesis, Cancer Res, 54, 321 Nees, 1993, Expression of mutated p53 occurs in tumor-distant epithelia of head and neck cancer patients: a possible molecular basis for the development of multiple tumors, Cancer Res, 53, 4189 Chung, 1993, Discordant p53 gene mutations in primary head and neck cancers and corresponding second primary cancers of the upper aerodigestive tract, Cancer Res, 53, 1676 Bosch, 1989, Extensive changes in cytokeratin expression patterns in pathologically affected human gingiva, Virch Arch B Cell Pathol, 58, 59, 10.1007/BF02890059 Maestro, 1993, Three discrete deletions at 3p in head and neck cancer, Cancer Res, 53, 5775 Sporn, 1976, Prevention of chemical carcinogenesis by vitamin A and its synthetic analogs (retinoids), 35, 1332 Wattenberg, 1985, Chemoprevention of cancer, Cancer Res, 45, 1 Morse, 1993, Cancer Chemoprevention: principles and prospects, Carcinogenesis, 14, 1737, 10.1093/carcin/14.9.1737 Micozzi, 1990, Carotenoid analyses of selected raw and cooked foods associated with a lower risk for cancer, J Natl Cancer Inst, 82, 282, 10.1093/jnci/82.4.282 Thorling, 1993, Dietary non-nutritive cancer protective factors, Eur J Cancer Prev, 2, 95, 10.1097/00008469-199303000-00002 Marshall, 1982, Diet in the epidemiology of oral cancer, Nutr Cancer, 3, 145, 10.1080/01635588109513716 Ibrahim, 1977, Plasma vitamin ‘A’ and carotene levels in squamous cell carcinoma of oral cavity and oropharynx, Clin Oncol, 3, 203 Wollbach, 1925, Tissue changes following deprivation of fat soluble A vitamin, J Exp Med, 42, 753, 10.1084/jem.42.6.753 Shklar, 1980, Inhibition of hamster buccal pouch carcinogenesis by 13-cis retinoic acid, Oral Surg Oral Med Oral Pathol, 50, 45, 10.1016/0030-4220(80)90330-8 Shklar, 1980, Retinoid inhibition of experimental lingual carcinogenesis: ultrastructural observations, J Natl Cancer Inst, 65, 1307 Shklar, 1980, Retinoid inhibition of lingual carcinogenesis, Oral Surg Oral Med Oral Pathol, 49, 325, 10.1016/0030-4220(80)90142-5 Burge-Bottenbley, 1983, Retardation of experimental oral cancer development by retinyl acetate, Nutr Cancer, 5, 121, 10.1080/01635588309513788 Inoue, 1993, Chemoprevention of tongue carcinogenesis in rats, Oral Surg Oral Med Oral Pathol, 76, 608, 10.1016/0030-4220(93)90070-K Stich, 1991, Remission of precancerous lesions in the oral cavity of tobacco chewers and maintenance of the protective effect of β-carotene or vitamin A, Am J Clin Nutr, 53, 298S, 10.1093/ajcn/53.1.298S Hong, 1990, Prevention of second primary tumors with isotretinoin in squamous cell carcinoma of the head and neck, N Engl J Med, 323, 795, 10.1056/NEJM199009203231205 Bollag, 1992, Retinoids in cancer prevention and therapy, Ann Oncol, 3, 513, 10.1093/oxfordjournals.annonc.a058252 Tallman, 1992, Retinoids in cancer treatment, J Clin Pharmacol, 32, 868, 10.1002/j.1552-4604.1992.tb04633.x Mori, 1993, Chemopreventive retinoids, Drugs Future, 18, 737 Glass, 1989, Positive and negative regulation of gene transcription by a retinoic acid-thyroid hormone receptor heterodimer, Cell, 59, 697, 10.1016/0092-8674(89)90016-0 Sonis, 1981, Preliminary immunologic studies on retinoid inhibition of experimental carcinogenesis, J Oral Med, 36, 117 Lippman, 1989, Retinoids for the prevention of cancer, 243 Mayne, 1991, Dietary retinol: prevention or promotion of carcinogenesis in humans?, Cancer Causes Cont, 2, 443, 10.1007/BF00054305 Schroder, 1980, Retinoids : tumor preventers or tumor enhancers?, J Natl Cancer Inst, 65, 671, 10.1093/jnci/65.4.671 Birt, 1986, Update on the effects of vitamins A, C, and E and selenium on carcinogenesis, 183, 311 Moon, 1984, Retinoids and cancer, 327 Levij, 1968, Potentiating effect of vitamin A on 9,10 dimethyl, 1-2-benzanthracene-carcinogenesis in the hamster cheek pouch, Cancer, 22, 300, 10.1002/1097-0142(196808)22:2<300::AID-CNCR2820220207>3.0.CO;2-2 Teelmann, 1989, Retinoids: toxicology and teratogebicity to date, Pharmacol Therapeut, 40, 29, 10.1016/0163-7258(89)90072-7 Chiesa, 1993, Fenretinide (4-HPR) in chemoprevention of oral leukoplakia, J Cell Biochem, 17F, 255, 10.1002/jcb.240531038 Modiano, 1990, Ocular toxic effects of fenretinide, J Natl Cancer Inst, 82, 1063, 10.1093/jnci/82.12.1063 Tanaka T, Makita H, Ohnishi M. Chemoprevention of 4-NQO-induced oral carcinogenesis by newly synthesized retinoid KYN-54 and arotenoid Ro 40-8757. Submitted. Mori, 1993, Inhibitory effect of 5-hydroxy-4-(2-phenyl-(E)-ethyl)-2(5H)-furanone, a novel synthesized retinoid, on azoxymethane-induced intestinal carcinogenesis in rats, Cancer Lett, 66, 93, 10.1016/0304-3835(92)90220-P Richtsmeier, 1993, Biologic modifiers and chemoprevention of cancer of the oral cavity, N Engl J Med, 328, 58, 10.1056/NEJM199301073280111 Bertram, 1987, Rationale and strategies for chemoprevention for cancer in humans, Cancer Res, 47, 3012 Khachik, 1986, Separation, identification, and quantification of the major carotenoid and chlorophyll constituents in extracts of several green vegetables by liquid chromatography, J Agr Food Chem, 34, 603, 10.1021/jf00070a006 Bendich, 1989, Biological actions of carotenoids, FASEB J, 3, 1927, 10.1096/fasebj.3.8.2656356 Monn, 1989, Comparative aspects of carotenoids and retinoids as Chemopreventive agents for cancer, J Nutr, 119, 127, 10.1093/jn/119.1.127 Lim, 1992, Antioxidant activity of xanthophyls on peroxy radical-mediated phospholipid peroxidation, Biochim Biophys Acta, 1126, 178, 10.1016/0005-2760(92)90288-7 Matthews-Roth, 1982, Antitumor activity of β-carotene, canthaxanthin and phytoene, Oncology, 39, 33, 10.1159/000225601 Schwartz, 1986, Beta carotene is associated with the regression of hamster buccal pouch carcinoma and the induction of tumor necrosis factor in macrophages, Biochem Biophys Res Commun, 136, 1130, 10.1016/0006-291X(86)90451-1 Suda, 1986, Inhibition of experimental oral carcinogenesis by topical beta carotene, Carcinogenesis, 7, 711, 10.1093/carcin/7.5.711 Suda, 1987, GGT reduction in beta carotene inhibition of hamster buccal pouch carcinogenesis, Eur J Cancer Clin Oncol, 23, 43, 10.1016/0277-5379(87)90417-2 Shklar, 1988, Tumor necrosis factor in experimental cancer regression with alpha tocopherol, beta-carotene, canthax- anthin and algae extract, Eur J Cancer Clin Oncol, 24, 839, 10.1016/0277-5379(88)90192-7 Schwartz, 1989, Prevention and inhibition of oral cancer in the hamster buccal pouch model associated with carotenoid immune enhancement, Tumor Biol, 10, 297, 10.1159/000217629 Okuzumi, 1990, Inhibitory effects of fucoxanthin, a natural carotenoid, on N-myc expression and cell cycle progression in human malignant tumor cells, Cancer Lett, 55, 75, 10.1016/0304-3835(90)90068-9 Tanaka, 1994, Chemoprevention of mouse urinary bladder carcinogenesis by the naturally occurring carotenoid astaxanthin, Carcinogenesis, 15, 15, 10.1093/carcin/15.1.15 Zhang, 1991, Carotenoids enhance gap junctional communication and inhibit lipid peroxidation in C3H/10T1/2 cells: relationship to their cancer Chemopreventive action, Carcinogenesis, 12, 2109, 10.1093/carcin/12.11.2109 Tanaka T, Makita H, Ohnishi M. Inhibitory effects of β-carotene, canthaxanthin and astaxanthin on 4-NQO-induced oral carcinogenesis in rats. Submitted. Schwartz, 1988, Regression of experimental oral carcinomas by local injection of beta carotene and canthaxanthin, Nutr Cancer, 11, 35, 10.1080/01635588809513967 Tannenbaum, 1980, Reaction of nitrite with vitamins C and E, Ann NY Acad Sci, 355, 267, 10.1111/j.1749-6632.1980.tb21345.x Mirvish, 1981, Inhibition of the formation of carcinogenic N-nitroso compounds by ascorbic acid and other compounds, 557 Schwartz, 1993, Vitamin C enhances the development of carcinomas in the hamster buccal pouch experimental model, Oral Surg Oral Med Oral Pathol, 76, 718, 10.1016/0030-4220(93)90041-2 Brandt, 1991, Regression of oral lesions with the use of antioxidant vitamins and beta-carotene supplements Sporn, 1980, Combination chemoprevention of cancer, Nature, 287, 107, 10.1038/287107a0 Ip, 1991, Combination of blocking agents and suppressing agents in cancer, Carcinogenesis, 12, 365, 10.1093/carcin/12.2.365 Reddy, 1990, Chemoprevention of colon carcinogenesis by concurrent administration of piroxicam, a nonsteroidal antiinflammatory drug, with d,l-α-difluoromethylornithine, an ornithine decarboxylase inhibitor, in diet, Cancer Res, 50, 2562 Bendich, 1988, Safety of oral intake of vitamin E, Am J Clin Nutr, 48, 612, 10.1093/ajcn/48.3.612 Boone, 1990, Identification of candidate Chemopreventive agents and their evaluation in animal models and human clinical trials: a review, Cancer Res, 50, 2 Harman, 1969, Dimethylbenzanthracene-induced cancer. Inhibit- ing effect of dietary vitamin E, Clin Res, 17, 125 Gijare, 1990, Modulatory effects of snuff, retinoic acid, and β-carotene on DMBA-induced hamster cheek pouch carcinogenesis in relation to keratin expression, Nutr Cancer, 14, 253, 10.1080/01635589009514101 Cerutti, 1991, Inflammation and oxidative stress in carcinogenesis, Cancer Res, 3, 1 Cerutti, 1985, Prooxidant states and tumor promotion, Science, 227, 375, 10.1126/science.2981433 Shklar, 1982, Inhibition of oral mucosal carcinogenesis by vitamin E, J Natl Cancer Inst, 68, 791 Okukoya, 1984, Retardation of experimental oral cancer by topical vitamin E, Nutr Cancer, 6, 98 Trickier, 1987, Prevention by vitamin E of oral carcinogenesis, J Natl Cancer Inst, 78, 165, 10.1093/jnci/78.1.165 Shklar, 1987, Regression by vitamin E of experimental oral cancer, J Natl Cancer Inst, 78, 987 Borek, 1990, Vitamin E as an anticarcinogen, Ann NY Acad Sci, 570, 417, 10.1111/j.1749-6632.1989.tb14944.x Shamburger, 1972, Increase in peroxidation in carcinogenesis, J Natl Cancer Inst, 48, 1491 Shklar, 1990, Prevention of experimental cancer and immunostimulation by vitamin E (immunosurveillance), J Oral Pathol Med, 19, 60, 10.1111/j.1600-0714.1990.tb00797.x Garewal, 1993, Beta-carotene and vitamin E in oral cancer prevention, J Cell Biochem, 17F, 262, 10.1002/jcb.240531039 Schwartz, 1987, Regression of experimental oral cancer by beta carotene and algae extract, J Oral Maxillofac Surg, 45, 510, 10.1016/S0278-2391(87)80011-3 Schwanz, 1988, Prevention of experimental oral cancer by extracts of Spirulina dunaliella alagae, Nutr Cancer, 11, 127, 10.1080/01635588809513979 Niukian, 1987, Effects of onion extract on the development of hamster buccal pouch carcinogenesis as expressed in tumor burden, Nutr Cancer, 9, 171, 10.1080/01635588709513924 Niukian, 1987, In vitro inhibitory effect of onion extract on hamster buccal pouch carcinogenesis, Nutr Cancer, 10, 137, 10.1080/01635588709513950 Meng, 1990, Inhibition of experimental carcinogenesis by painting with garlic extract, Nutr Cancer, 14, 207, 10.1080/01635589009514095 Miller, 1988, Inhibition of hamster buccal pouch carcinogenesis by green coffee beans, Oral Surg Oral Med Oral Pathol, 65, 745, 10.1016/0030-4220(88)90022-9 Miller, 1991, Kahweol and cafestol: inhibitors of hamster buccal pouch carcinogenesis, Nutr Cancer, 15, 41, 10.1080/01635589109514110 Miller, 1992, Inhibition of hamster buccal pouch carcinogenesis by limonin 17-β-d-glucopyranoside, Nutr Cancer, 17, 1, 10.1080/01635589209514167 Tanaka, 1992, Inhibitory effects of the natural products indole-3-carbinol and sinigrin during initiation and promotion phases of 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis, Jpn J Cancer Res, 83, 835, 10.1111/j.1349-7006.1992.tb01988.x Tanaka, 1993, Inhibition of 4-nitroquinoline 1-oxide-induced rat tongue carcinogenesis by the naturally occurring plant phenolics caffeic ellagic, chlorogenic and ferulic acids, Carcinogenesis, 14, 1321, 10.1093/carcin/14.7.1321 Tanaka, 1994, Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis by dietary protocatechuic acid during initiation and postinitiation phases, Cancer Res, 54, 2359 Toda, 1985, Natural antioxidants. III. Antioxidative components isolated from Rhizome of Curcume longa L, Chem Pharm Bull, 33, 1725, 10.1248/cpb.33.1725 Tanaka, 1993, Chemoprevention of diethylnitrosamine-induced hepatocarcinogenesis by simple phenolic acid protocatechuic acid in rats, Cancer Res, 53, 2775 Tanaka, 1993, Chemoprevention of colon carcinogenesis by the natural product of a simple phenolic compound protocatechuic acid: suppressing effects on tumor development and biomarkers expression of colon tumorigenesis, Cancer Res, 53, 3908 Tanaka, 1994, Chemoprevention of 4-NQO-induced oral carcinogenesis by dietary curcumin and hesperidin: comparison with the protective effect of β-carotene, Cancer Res, 54, 4653 Goodwin, 1983, Selenium and glutathione peroxidase levels in patients with epidermoid cancer of the oral cavity and oropharynx, Cancer, 51, 110, 10.1002/1097-0142(19830101)51:1<110::AID-CNCR2820510122>3.0.CO;2-V Shamburger, 1970, Relationship of selenium to cancer. I. Inhibitory effect of selenium on carcinogenesis, J Natl Cancer Inst, 44, 931 Wontzram, 1981, Effect of dietary selenium on the interaction between 2-acetylaminofluorene and rat liver DNA in vivo, Cancer Res, 40, 2670 Massadi, 1986, Inhibition of oral carcinogenesis by a protease inhibitor, J Natl Cancer Inst, 76, 447 Kennedy, 1993, Effects of various preparations of dietary protease inhibitors on oral carcinogenesis in hamsters induced by DMBA, Nutr Cancer, 19, 191, 10.1080/01635589309514249 Parkins, 1982, Delay in hamster buccal pouch carcinogenesis by aspirin and indomethacin, Oral Surg Oral Med Oral Pathol, 53, 170, 10.1016/0030-4220(82)90283-3 Cornwall, 1983, Oral mucosal tumor inhibition by ibuprofen, J Oral Maxillofac Surg, 41, 795, 10.1016/S0278-2391(83)80046-9 Giunta, 1974, Bacillus Calmette-Guerin and antilymphocyte serum in carcinogenesis. Effects on the hamster pouch, Arch Pathol, 98, 237 Eisenberg, 1977, Levamisole and hamster buccal pouch carcinogenesis, Oral Surg Oral Med Oral Pathol, 43, 562, 10.1016/0030-4220(77)90109-8 Malament, 1981, Inhibition of DMBA carcinogenesis of hamster buccal pouch by phenanthrene and dimethylnaphthalene, Carcinogenesis, 2, 723, 10.1093/carcin/2.8.723 Tanaka, 1987, Inhibitory effect of butylated hydroxytoluene, butylated hydroxyanisole and disulfiram on 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in male ACI rats, J Nutr Growth Cancer, 4, 239 Tanaka, 1989, Inhibitory effects of non-steroidal anti-inflammatory drugs, piroxicam and indomethacin on 4-nitroquinoline 1-oxide-induced tongue carcinogenesis in male ACI/N rats, Cancer Lett, 48, 177, 10.1016/0304-3835(89)90115-8 Tanaka, 1993, Chemoprevention of oral carcinogenesis by d,l-α-difluoromethylornithine, an ornithine decarboxylase inhibitor: dose-dependent reduction in 4-nitroquinoline 1-oxide-induced tongue neoplasms in rats, Cancer Res, 53, 772 De Vries, 1993, N-Acetyl-l-cysteine, J Cell Biochem, 17F, 270, 10.1002/jcb.240531040 Benson, 1993, Oltipraz: a laboratory and clinical review, J Cell Biochem, 17F, 278, 10.1002/jcb.240531041 Goodwin, 1986, Inhibition of hamster tongue carcinogenesis by selenium and retinoic acid, Ann Otol Rhinol Laryngol, 95, 162, 10.1177/000348948609500210 Shklar, 1989, Regression of experimental cancer by oral administration of combined alpha-tocopherol and beta-carotene, Nutr Cancer, 12, 321, 10.1080/01635588909514032 Shklar, 1993, Oral cancer inhibition by micronutrients. The experimental basis for clinical trials, Oral Oncol, Eur J Cancer, 29B, 9, 10.1016/0964-1955(93)90004-X Greenwald, 1986, Diet and Chemoprevention in NCI's research strategy to achieve national cancer control objectives, Am Rev Public Health, 7, 267, 10.1146/annurev.pu.07.050186.001411 Greenwald, 1990, Concepts in cancer Chemoprevention research, Cancer, 65, 1483, 10.1002/1097-0142(19900401)65:7<1483::AID-CNCR2820650706>3.0.CO;2-E Kelloff, 1990, Progress in applied Chemoprevention research, Semin Oncol, 17, 438 Lippman, 1990, Biomarkers as intermediate endopoints in chemoprevention trials, J Natl Cancer Inst, 82, 555, 10.1093/jnci/82.7.555 Malone, 1989, Chemoprevention research, 31 Tanaka, 1992, Cancer Chemoprevention, Cancer J, 5, 11 Tanaka T. Chemoprevention of human cancer: biology and therapy. Crit Rev Oncol/Hematol, in press. Hong, 1993, Recent advances in head and neck cancer-larynx preservation and cancer Chemoprevention: the Seventeenth Annual Richard and Hinda Rosenthal Foundation Award Lecture, Cancer Res, 53, 5113 Benner, 1992, Current status of Chemoprevention of head and neck cancer, Oncology, 6, 61 Heyne, 1991, Chemoprevention in head and neck cancer, Hematol/Oncol Clin North Am, 5, 783, 10.1016/S0889-8588(18)30416-7 Benner, 1993, Regression of oral leukoplakia with α-tocopherol: a community clinical oncology program (CCOP) chemoprevention study, J Natl Cancer Inst, 85, 44, 10.1093/jnci/85.1.44 Lippman, 1987, Retinoids as preventive and therapeutic anticancer agents, Cancer Treat Rep, 71, 391 Lippman, 1987, Retinoids as preventive and therapeutic anticancer agents, Cancer Treat Rep, 71, 493 Lippman, 1992, Retinoid chemoprevention of upper aerodigestive tract carcinogenesis, 93 Stich, 1988, Remission of oral leukoplakia and micronuclei in tobacco/betal quid chewers treated with beta-carotene and with beta-carotene plus vitamin A, Int J Cancer, 42, 195, 10.1002/ijc.2910420209 Koch, 1978, Biochemical treatment of precancerous oral lesions: the effectiveness of various analogues of retinoic acid, J Maxillofac Surg, 6, 59, 10.1016/S0301-0503(78)80069-1 Shah, 1983, Effect of retinoids on oral leukoplakia, Am J Surg, 146, 466, 10.1016/0002-9610(83)90232-5 Hong, 1986, 13-cis-retinoic acid in the treatment of oral leukoplakia, N Engl J Med, 315, 1501, 10.1056/NEJM198612113152401 Koch, 1981, Effect of retinoids on precancerous lesions of oral mucosa, 307 Garewal, 1990, Response of oral leukoplakia to beta-carotene, J Clin Oncol, 8, 1715, 10.1200/JCO.1990.8.10.1715 Malaker, 1991, Management of oral mucosal dysplasia with beta-carotene retinoic acid: a pilot crossover study, Cancer Detect Prev, 15, 335 Kaugars, 1990, Beta-carotene supplementation in the treatment of oral lesions, Oral Surg Oral Med Oral Palhol, 70, 607 Toma, 1991, Response of oral leukoplakia to β-carotene treatment, Vol. 2, 222 Lippman, 1993, Comparison of low-dose isotretinoin with beta carotene to prevent oral carcinogenesis, N Engl J Med, 328, 15, 10.1056/NEJM199301073280103 Stich, 1988, Response of oral leukoplakia to the administration of vitamin A, Cancer Lett, 40, 93, 10.1016/0304-3835(88)90266-2 Han, 1990, Evaluation of N-4-(hydroxycarbophenyl)retinamide as a cancer prevention against and as a center chemotherapeutic agent, In Vivo (Athens), 4, 153 Chiasa, 1992, Prevention of local relapses and new localizations of oral leukoplakias with the synthetic retinoid fenretinide (4-HPR). Preliminary results, Oral Oncol, Eur J Cancer, 28B, 97, 10.1016/0964-1955(92)90035-Y Chiasa, 1993, Fenretinide (4-HPR) in chemoprevention of oral leukoplakia, J Cell Biochem, 17F, 255, 10.1002/jcb.240531038 Kaugars, 1993, A review of the use of antioxidant supplements in the treatment of human oral leukoplakia, J Cell Biochem, 17F, 292, 10.1002/jcb.240531042 Malone, 1991, Studies evaluating antioxidants and beta-carotene as chemopreventives, Am J Clin Nutr, 53, 305S, 10.1093/ajcn/53.1.305S Garewal, 1992, Beta-carotene in oral leukoplakia, 11, 141 De Vries, 1991, The EUROSCAN trial, Br J Cancer, 64, 985, 10.1038/bjc.1991.451 Benner, 1994, Prevention of second primary tumors with isotretinoin in patients with squamous cell carcinoma of the head and neck: long-term follow-up, J Natl Cancer Inst, 86, 140, 10.1093/jnci/86.2.140 Pilot, 1993, Stage of tumor progression, progressor agents, and human risk, 202, 37 Sporn, 1991, Carcinogenesis and cancer: different perspectives on the same disease, Cancer Res, 51, 6215