Chemical Property and Antibacterial Activity of Metronidazole-decorated Ti through Adhesive Dopamine
Tóm tắt
In order to present a novel metronidazole-decorated Ti implanted with antibacterial activity through adhesive dopamine, and prepare metronidazole-decorated Ti, Ti substrates were pre-modified with dopamine (DA) coating, and metronidazole was subsequently immobilized onto the surface of DA-modified Ti substrates. The prepared MET-decorated Ti interfaces were prepared for surface characterization tests: contacting angle measurements, scanning electron microscope, ATR-FTIR spectroscopy and in vitro anti-biofilm formation assay. Statistical tests were performed using by SPSS16.0. Contacting angle measurement, scanning electron microscopy, and ATR-FTIR spectroscopy confIrmed the successful presence of MET grafted on the Ti surface. In addition, the MET-decorated Ti induced good in vitro antibacterial activity toward Escherichia coli and Streptococcus mutans,Gram-negative and Gram-positive bacteria, respectively. The modified Ti substrate with enhanced antibacterial activity holds a great potential as implanting material for applications in dental and bone graft substitutes.
Tài liệu tham khảo
Mouhyi J, Dohan Ehrenfest DM, Albrektsson T. The Peri-Implantitis: Implant Surfaces, Microstructure, and Physicochemical Aspects[J]. Clinical Implant Dentistry and Related Research, 2012, 14(2): 170–183
Kumeria T, Mon H, Aw MS, et al. Advanced Biopolymer-coated Drug-releasing Titania nanotubes (TNTs) Implants with Simultaneously Enhanced Osteoblast Adhesion and Antibacterial Properties[J]. Colloids and Surfaces B: Biointerfaces, 2015, 130: 255–263
Zhao L, Chu PK, Zhang Y, et al. Antibacterial Coatings on Titanium Implants[J]. J. Biomed. Mater. Res. B Appl. Biomater., 2009, 91(1):470–480
Wang C, Feng Y, Wang D, et al. Effect of a Hybrid Micro/Nano-integrated Titanium Surface on Behavior of Rat Osteoblasts[J]. Journal of Wuhan University of Technology -Materials Science Edition, 2017, 32(2): 459–468
Lv H, Chen Z, Yang X, et al. Layer-by-layer Self-assembly of Minocycline-loaded Chitosan/Alginate Multilayer on Titanium Substrates to Inhibit Biofilm Formation[J]. Journal of Dentistry, 2014, 42(11): 1 464–1 472
Ungureanu C, Dumitriu C, Popescu S, et al. Enhancing Antimicrobial Activity of TiO2/Ti by Torularhodin Bioinspired Surface Modification[J]. Bioelectrochemistry, 2016, 107: 14–24
Jiang J, Zhu L, Zhu L, et al. Surface Characteristics of a Self-polymerized Dopamine Coating Deposited on Hydrophobic Polymer Films[J]. Langmuir the Acs Journal of Surfaces & Colloids, 2011, 27(23):14 180
Zhang Y, Zheng Y, Li Y, et al. Tantalum Nitride-Decorated Titanium with Enhanced Resistance to Microbiologically Induced Corrosion and Mechanical Property for Dental Application[J]. Plos One, 2015, 10(6): e130774
ZHANG Rui, WAN Yi, AI Xing et al. Fabrication of Micro/Nano-textured Titanium Alloy Implant Surface and Its Infuence on Hydroxyapatite Coatings[J]. Journal of Wuhan University of Technology-Mater. Sci. Ed., 2016(2): 441–446
Ma Yihui, Wang Ruoli, Cheng Xiangrong, et al. The Behavior of New Hydrophilic Composite Bone Cements for Immediate Loading of Dental Implant[J]. Journal Wuhan University of Technology- Materials Science Edition, 2013, 28(3): 627–633
He S, Zhou P, Wang L, et al. Antibiotic-decorated Titanium with En hanced Antibacterial Activity Through Adhesive Polydopamine for Dental/Bone Implant[J]. J. R. Soc. Interface, 2014, 11(95): 20 140 169
Zhao L, Chu PK, Zhang Y, et al. Antibacterial Coatings on Titanium Implants[J]. Journal of Biomedical Materials Research.Part B, Applied Biomaterials, 2009, 91(1): 470–480
Cazander G, Mc VDV, Vandenbrouckegrauls CM, et al. Maggot Excretions Inhibit Bioflm Formation on Biomaterials[J]. Clinical Orthopaedics & Related Research, 2010, 468(10): 2 789–2 796
Hickok NJ, Shapiro IM. Immobilized Antibiotics to Prevent Orthopedic Implant Infections[J]. Advanced Drug Delivery Reviews, 2012, 64(12): 1 165–1 176
Lee H, Dellatore SM, Miller WM, et al. Mussel-inspired Surface Chemistry for Multifunctional Coatings.[J]. Science, 2007, 318(5849): 426–430
Ku SH, Ryu J, Hong SK, et al. General Functionalization Route for cell Adhesion on Non-wetting Surfaces[J]. Biomaterials, 2010, 31(9): 2 535–2 541
Broggini N, Mcmanus LM, Hermann JS, et al. Peri-implant Infammation Defned by the Implant-abutment Interface[J]. J. Dent. Res., 2006, 85(5): 473–478
Nastri L, DeRosa A, DeGregorio V, et al. A New Controlled-Release Material Containing Metronidazole and Doxycycline for the Treatment of Periodontal and Peri-Implant Diseases: Formulation and in vitro Testing[J]. Int. J. Dent., 2019: 9374607
Lynge ME, van der Westen R, Postma A, et al. Polydopamine-a Nature-inspired Polymer Coating for Biomedical Science[J]. Nanoscale, 2011, 3(12): 4 916–4 928
Yang K, Lee JS, Kim J, et al. Polydopamine-mediated Surface Modifcation of Scaffold Materials for Human Neural Stem Cell Engineering[J]. Biomaterials, 2012, 33(29): 6 952–6 964
O'Toole G, Kaplan HB, Kolter R. Bioflm Formation as Microbial Development[J]. Annual Review of Microbiology, 2000, 54(1): 49–79
Kazemzadehnarbat M, Lai BF, Ding C, et al. Multilayered Coating on Titanium for Controlled Release of Antimicrobial Peptides for the Prevention of Implant-associated Infections[J]. Biomaterials, 2013, 34(24): 5 969–5 977
Walsh FM, Amyes SG. Microbiology and Drug Resistance Mechanisms of Fully Resistant Pathogens[J]. Current Opinion in Microbiology, 2004, 7(5): 439–444