Chemical Fingerprint and Multicomponent Quantitative Analysis for the Quality Evaluation of Cyclocarya paliurus Leaves by HPLC–Q–TOF–MS

Springer Science and Business Media LLC - Tập 22 Số 11 - Trang 1927
Yanni Cao1, Shengzuo Fang2,1, Zhiqi Yin3, Xiangxiang Fu2,1, Xulan Shang2,1, Wanxia Yang2,1, Huimin Yang3
1College of Forestry, Nanjing Forestry University, Nanjing 210037, China
2Co-Innovation Center for Sustainable Forestry in Southern China, Nanjing Forestry University, Nanjing 210037, China
3Department of Natural Medicinal Chemistry and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing 10009, China

Tóm tắt

Cyclocarya paliurus is an edible and medicinal plant containing various bioactive components with significant health benefits. A combinative method using high-performance liquid chromatography (HPLC) fingerprint and quantitative analysis was developed and successfully applied for characterization and quality evaluation of C. paliurus leaves collected from 18 geographical locations of China. For the fingerprint analysis, 21 common peaks were observed among the 18 samples, and these peaks were identified by high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (HPLC–Q–TOF–MS), while a simultaneous quantification of 16 markers was conducted to interpret the variations of contents of these bioactive compounds among the C. paliurus leaves from different geographical locations. Quantification results showed that the contents of these sixteen investigated compounds varied greatly among the leaves from different locations. The developed new method would be a valuable reference for further study and development of this bioactive plant.

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Tài liệu tham khảo

Fang, 2006, Methods to break seed dormancy in Cyclocarya paliurus (Batal.) Iljinskaja, Sci. Hortic., 110, 305, 10.1016/j.scienta.2006.06.031

Birari, 2007, Pancreatic lipase inhibitors from natural source: Unexplored potential, Drug Discov. Today, 12, 879, 10.1016/j.drudis.2007.07.024

Xie, 2010, Isolation, chemical composition and antioxidant activities of a watersoluble polysaccharide from Cyclocarya paliurus (Batal.) Iljinskaja, Food Chem., 119, 1626, 10.1016/j.foodchem.2009.09.055

Hou, 2014, Effect of the flavonoids from Cyclocarya paliurus on spontaneous hypertension rats, Pharm. Clin. Chin. Mater. Med., 30, 62

Kurihara, 2003, Hypoglycemic action of Cyclocarya paliurus (Batal.) Iljinskaja in normal and diabetic mice, Biosci. Biotechnol. Biochem., 67, 877, 10.1271/bbb.67.877

Zhang, 2010, Phenolic compounds from the leaves of Cyclocarya paliurus (Batal.) Ijinskaja and their inhibitory activity against PTP1B, Food Chem., 119, 1491, 10.1016/j.foodchem.2009.09.031

Kurihara, 2003, Hypolipemic effect of Cyclocarya paliurus (Batal) Iljinskaja in lipid-loaded mice, Biol. Pharm. Bull., 26, 383, 10.1248/bpb.26.383

Yang, 2016, Structural characterization and hypolipidemic effect of Cyclocarya paliurus polysaccharide in rat, Int. J. Biol. Macromol., 91, 1073, 10.1016/j.ijbiomac.2016.06.063

Wu, 2017, Antihyperlipidaemic effect of triterpenic acid-enriched fraction from Cyclocarya paliurus leaves in hyperlipidaemic rats, Pharm. Biol., 55, 712, 10.1080/13880209.2016.1267231

Liu, 2017, Immunomodulatory effects of an acetylated Cyclocarya paliurus polysaccharide on murine macrophages raw264.7, Int. J. Biol. Macromol., 98, 576, 10.1016/j.ijbiomac.2017.02.028

Xie, 2013, Purification, physicochemical characterization and anticancer activity of a polysaccharide from Cyclocarya paliurus leaves, Food Chem., 136, 1453, 10.1016/j.foodchem.2012.09.078

Zhang, 2010, Water-soluble phenolic compounds and their anti-HIV-1 activities from the leaves of Cyclocarya paliurus, J. Food Drug Anal., 18, 398

Xie, 2012, Ultrasonic-assisted extraction, antimicrobial and antioxidant activities of Cyclocarya paliurus (Batal.) Iljinskaja polysaccharides, Carbohydr. Polym., 89, 177, 10.1016/j.carbpol.2012.02.068

Shu, 1995, Cyclocariosides II and III: Two secodammarane triterpenoid saponins from Cyclocarya paliurus, Planta Med., 61, 551, 10.1055/s-2006-959369

Shu, 1995, Studies on the sweet principles from the leaves of Cyclocarya paliurus (Batal.) Iljinsk, Acta Pharm. Sin., 30, 757

Kennelly, 1995, Novel highly sweet secodammarane glycosides from Pterocarya paliurus, J. Agric. Food Chem., 43, 2602, 10.1021/jf00058a009

Wright, 2014, Isolation and structural clarification of triterpenes from Cyclocarya paliurus: Cyclocaric acid A and B, Planta Med., 80, 139, 10.1055/s-0034-1382440

Li, 2015, Chemical fingerprint and quantitative analysis for quality control of polyphenols extracted from pomegranate peel by HPLC, Food Chem., 176, 7, 10.1016/j.foodchem.2014.12.040

Fang, 2011, Provenance and temporal variations in selected flavonoids in leaves of Cyclocarya paliurus, Food Chem., 124, 1382, 10.1016/j.foodchem.2010.07.095

Deng, 2012, Integrated effects of light intensity and fertilization on growth and flavonoid accumulation in Cyclocarya paliurus, J. Agric. Food Chem., 60, 6286, 10.1021/jf301525s

Shang, 2015, Simultaneous determination of flavonoids and triterpenoids in Cyclocarya paliurus leaves using high-performance liquid chromatography, Afr. J. Tradit. Complemt. Altern. Med., 12, 125, 10.4314/ajtcam.v12i3.16

Gu, 2004, Comparison of high-speed counter-current chromatography and high-performance liquid chromatography on fingerprinting of Chinese traditional medicine, J. Chromatogr. A, 1022, 139, 10.1016/j.chroma.2003.09.038

Chou, 2009, Quantitative and fingerprint analyses of Chinese sweet tea plant (Rubus suavissimus S. Lee), J. Agric. Food Chem., 57, 1076, 10.1021/jf8029397

Zhao, 2013, Chromatographic and mass spectrometric fingerprinting analyses of Angelica sinensis (Oliv.) Diels-derived dietary supplements, Anal. Bioanal. Chem., 405, 4477, 10.1007/s00216-012-6668-1

Tang, 2014, Investigation of a novel method for quality control of Chinese herbal compound prescription: HPLC fingerprint and multi-index components combining blending technology control for quality stability of Zhou’s prescription extract, Anal. Methods, 6, 4158, 10.1039/c3ay41884g

Yudthavorasit, 2014, Characteristic fingerprint based on gingerol derivative analysis for discrimination of ginger (Zingiber officinale) according to geographical origin using HPLC-DAD combined with chemometrics, Food Chem., 158, 101, 10.1016/j.foodchem.2014.02.086

Arceusz, 2013, Quality consistency evaluation of Melissa officinalis L. commercial herbs by HPLC fingerprint and quantitation of selected phenolic acids, J. Pharm. Biomed. Anal., 83, 215, 10.1016/j.jpba.2013.05.020

Salminen, 2015, Rapid fingerprint analysis of plant extracts for ellagitannins, gallic acid, and quinic acid derivatives and quercetin-, kaempferol- and myricetin-based flavonol glycosides by UPLC-QqQ-MS/MS, J. Agric. Food Chem., 63, 4068, 10.1021/acs.jafc.5b00595

Wang, 2016, Variations in chemical fingerprints and major flavonoid contents from the leaves of thirty-one accessions of Hibiscus sabdariffa L., Biomed. Chromatogr., 30, 880, 10.1002/bmc.3623

Li, 2010, Combinative method using HPLC fingerprint and quantitative analyses for quality consistency evaluation of an herbal medicinal preparation produced by different manufacturers, J. Pharm. Biomed. Anal., 52, 597, 10.1016/j.jpba.2010.01.018

Qin, 2015, Quality assessment of raw and processed Arctium. lappa L. through multicomponent quantification, chromatographic fingerprint, and related chemometric analysis, J. Sep. Sci., 38, 1491, 10.1002/jssc.201401299

Viapiana, 2016, An approach based on HPLC-fingerprint and chemometrics to quality consistency evaluation of Matricaria chamomillal L. commercial samples, Front. Plant Sci., 7, 1561, 10.3389/fpls.2016.01561

Ni, 2012, Analysis of HPLC fingerprints: Discrimination of raw and processed Rhubarb samples with the aid of chemometrics, Anal. Methods, 4, 171, 10.1039/C1AY05661A

Kite, 2006, Data-directed scan sequence for the general assignment of C-glycosylflavone O-glycosides in plant extracts by liquid chromatography-ion trap mass spectrometry, J. Chromatogr. A, 1104, 123, 10.1016/j.chroma.2005.11.070

Li, 2016, Chemical constituents and quality control of two Dracocephalum species based on high-performance liquid chromatographic fingerprints coupled with tandem mass spectrometry and chemometrics, J. Sep. Sci., 39, 4071, 10.1002/jssc.201600645

Chen, 2017, Antioxidant activities and identification of bioactive components of Cyclocarya paliurus leaves by UPLC-QTOF-MS/MS, Food Sci., 38, 122

Cui, 2015, New triterpenoid saponins from the leaves of Cyclocarya paliurus, Chin. Chem. Lett., 26, 585, 10.1016/j.cclet.2014.11.033

Jiang, 2015, Cholesterol-lowering effects and potential mechanisms of different polar extracts from Cyclocarya paliurus leaves in hyperlipidemic mice, J. Ethnopharmacol., 176, 17, 10.1016/j.jep.2015.10.006

Oufir, 2009, Influence of environment and genotype on polyphenol compounds and vitro antioxidant capacity of native Andean potatoes (Solanum tuberosum L.), J. Food Compos. Anal., 22, 517, 10.1016/j.jfca.2008.11.010

Liu, 2016, Effect of regime and provenance on leaf characteristics, growth and flavonoid accumulation in Cyclocarya paliurus (Batal) Iljinskaja coppices, Bot. Stud., 57, 28, 10.1186/s40529-016-0145-7

Schmidt, 2010, Genotypic and climatic influence on the concentration and composition of flavonoids in kales (Brassica oleracea var. sabellica), Food Chem., 119, 1293, 10.1016/j.foodchem.2009.09.004

Lu, 2013, Effect of genotype, environment, and their interaction on phytochemical compositions and antioxidant properties of soft winter wheat flour, Food Chem., 138, 454, 10.1016/j.foodchem.2012.10.069

Deng, 2015, Variation and stability of growth and leaf flavonoid content in Cyclocarya paliurus across environments, Ind. Crops Prod., 76, 386, 10.1016/j.indcrop.2015.07.011

Solar, 2006, Seasonal variations of selected flavonoids, phenolic acids and quinones in annual shoots of common walnut (Juglans regia L.), Plant Sci., 170, 453, 10.1016/j.plantsci.2005.09.012

Fu, 2015, Seasonal and genotypic variation of water-soluble polysaccharide content in leaves of Cyclocarya paliurus, South. For., 77, 231, 10.2989/20702620.2015.1010698