Characterizing the spatio-temporal dynamics of the epileptogenic process with nonlinear EEG analyses

C.E. Elger1, F. Mormann1, T. Kreuz2,1, R.G. Andrzejak2,1, C. Rieke1, R. Sowa1, S. Florin1, P. David3, K. Lehnertz1
1Department of Epileptology, University of Bonn, Germany
2Research Center Jülich, John von Neumann Institute for Computing, Germany
3Institute for Radiation and Nuclear Physics, University of Bonn, Germany

Tóm tắt

In this overview we present our work investigating the spatio-temporal dynamics of the epileptogenic process using time series analysis techniques derived from the theory of nonlinear dynamics. Apart from a localization of epileptic foci in different anatomical locations during the seizure-free interval we discuss possibilities for seizure prediction, a field that represents one of the greatest challenges in epileptology. The unequivocal definition of a pre-seizure state of a sufficient length would enable investigation of basic mechanisms leading to seizure initiation in humans and provide a basis for the development of adequate seizure prevention strategies.

Từ khóa

#Epilepsy #Electroencephalography #Electrodes #Time series analysis #Humans #Drugs #Surgery #Medical treatment #Physics computing #Nuclear physics

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