Characterizing Human Ion Channels in Induced Pluripotent Stem Cell–Derived Neurons

SLAS Discovery - Tập 17 Số 9 - Trang 1264-1272 - 2012
Alison Haythornthwaite1, Sonja Stoelzle2, Alexander Hasler3, Andrea Kiss3, Johannes Mosbacher4,3, Michael George2, Andrea Brüggemann2, Niels Fertig2
1Nanion Technologies GmbH, Munich, Germany
21Nanion Technologies GmbH, Munich, Germany
32Actelion Pharmaceuticals Ltd, Switzerland
4*Neuroscience Research, F. Hoffmann-La Roche AG, Basel, Switzerland

Tóm tắt

Từ khóa


Tài liệu tham khảo

Zolles, 2009, Association with the Auxiliary Subunit PEX5R/Trip8b Controls Responsiveness of HCN Channels to cAMP and Adrenergic Stimulation, Neuron, 62, 814, 10.1016/j.neuron.2009.05.008

Bett, 2008, Modification of K+ Channel-Drug Interactions by Ancillary Subunits, J. Physiol., 586, 929, 10.1113/jphysiol.2007.139279

Israel, 2012, Probing Sporadic and Familial Alzheimer’s Disease Using Induced Pluripotent Stem Cells, Nature, 482, 216, 10.1038/nature10821

Paşca, 2011, Using iPSC-Derived Neurons to Uncover Cellular Phenotypes Associated with Timothy Syndrome, Nat. Med., 17, 1657, 10.1038/nm.2576

Stoelzle, 2011, Automated Patch Clamp on mESC-Derived Cardiomyocytes for Cardiotoxicity Prediction, J. Biomol. Screen., 16, 910, 10.1177/1087057111413924

Stoelzle, 2011, State-of-the-Art Automated Patch Clamp Devices: Heat Activation, Action Potentials, and High Throughput in Ion Channel Screening, Frontiers Pharmacol., 2, 76, 10.3389/fphar.2011.00076

Farre, 2009, Port-a-patch and Patchliner: High Fidelity Electrophysiology for Secondary Screening and Safety Pharmacology, Comb. Chem. High Throughput Screen., 12, 24, 10.2174/138620709787047966

Schröter, 1991, Cloning and Functional Expression of a TEA-Sensitive A-Type Potassium Channel from Rat Brain, FEBS Lett., 278, 211, 10.1016/0014-5793(91)80119-N

Barnard, 1998, XV. Subtypes of γ-Aminobutyric AcidA Receptors: Classification on the Basis of Subunit Structure and Receptor Function, Pharm. Rev., 50, 291