Characterization of the Partition Rate of Ibuprofen Across the Water-Octanol Interface and the Influence of Common Pharmaceutical Excipients

Kostewicz, 2014, In vitro models for the prediction of in vivo performance of oral dosage forms, Eur J Pharm Sci, 57, 342, 10.1016/j.ejps.2013.08.024 Tsume, 2014, The Biopharmaceutics Classification System: subclasses for in vivo predictive dissolution (IPD) methodology and IVIVC, Eur J Pharm Sci, 57, 152, 10.1016/j.ejps.2014.01.009 Nguyen, 2017, A survey on IVIVC/IVIVR development in the pharmaceutical industry—past experience and current perspectives, Eur J Pharm Sci, 102, 1, 10.1016/j.ejps.2017.02.029 Pestieau, 2017, In vitro biphasic dissolution tests and their suitability for establishing in vitro-in vivo correlations: a historical review, Eur J Pharm Sci, 102, 203, 10.1016/j.ejps.2017.03.019 Gao, 2017, Development and application of in vitro two-phase dissolution method for poorly water soluble drugs Sarode, 2014, Supersaturation, nucleation, and crystal growth during single- and biphasic dissolution of amorphous solid dispersions: polymer effects and implications for oral bioavailability enhancement of poorly water soluble drugs, Eur J Pharm Biopharm, 86, 351, 10.1016/j.ejpb.2013.10.005 Shi, 2016, Assessing supersaturation and its impact on in vivo bioavailability of a low-solubility compound ABT-072 with a dual pH, two-phase dissolution method, J Pharm Sci, 105, 2886, 10.1016/j.xphs.2016.04.036 Pestieau, 2017, Evaluation of different in vitro dissolution tests based on level A in vitro-in vivo correlations for fenofibrate self-emulsifying lipid-based formulations, Eur J Pharm Biopharm, 112, 18, 10.1016/j.ejpb.2016.10.030 Xu, 2018, Developing quantitative in vitro-in vivo correlation (IVIVC) for fenofibrate immediate release formulations with the biphasic dissolution-partition test method, J Pharm Sci, 107, 476, 10.1016/j.xphs.2017.06.018 Xu, 2017, In vitro characterization of ritonavir drug products and correlation to human in vivo performance, Mol Pharm, 14, 3801, 10.1021/acs.molpharmaceut.7b00552 Locher, 2016, Evolution of a mini-scale biphasic dissolution model: impact of model parameters on partitioning of dissolved API and modelling of in vivo-relevant kinetics, Eur J Pharm Biopharm, 105, 166, 10.1016/j.ejpb.2016.06.008 Fisk, 1999, Chapter 6. The kinetics of the partitioning of compounds between octanol and water, and its relationship to the movement of molecules in biological systems, In: Compton RG, Hancock G, eds. Comprehensive Chemical Kinetics, Vol 37: Applications of Kinetic Modelling, 37, 161 Sangster, 1997 Perlovich, 2004, Solvation of drugs as a key for understanding partitioning and passive transport exemplified by NSAIDs, Curr Drug Del, 1, 213, 10.2174/1567201043334786 Goldberg, 1967, Mechanisms of interphase transport I: theoretical considerations of diffusion and interfacial barriers in transport of solubilized systems, J Pharm Sci, 56, 1432, 10.1002/jps.2600561112 Howard, 1969, Two phase method for the investigation of interphase transport I: theoretical aspects, J Pharm Sci, 58, 1325, 10.1002/jps.2600581106 Howard, 1969, Two phase method for the investigation of interphase transport II: experimental aspects, J Pharm Sci, 58, 1330, 10.1002/jps.2600581107 Goldberg, 1969, Mechanisms of interphase transport II: theoretical considerations and experimental evaluation of interfacially controlled transport in solubilized systems, J Pharm Sci, 58, 1341, 10.1002/jps.2600581109 Grassi, 2007, 249 Grassi, 2002, Modeling partitioning of sparingly soluble drugs in a two-phase liquid system, Int J Pharm, 239, 157, 10.1016/S0378-5173(02)00101-1 Mudie, 2012, Mechanistic analysis of solute transport in an in vitro physiological two-phase dissolution apparatus, Biopharm Drug Dispos, 33, 378, 10.1002/bdd.1803 Gao, 1995, Diffusion in HPMC gels. I. Determination of drug and water diffusivity by pulsed-field-gradient spin-echo NMR, Pharm Res, 12, 955, 10.1023/A:1016293911499 Sigma-Aldrich Indulkar, 2017, Impact of micellar surfactant on supersaturation and insight into solubilization mechanisms in supersaturated solutions of atazanavir, Pharm Res, 34, 1276, 10.1007/s11095-017-2144-0 Steel, 2004, Solvent polarity across strongly associating interfaces, J Phys Chem B, 108, 16107, 10.1021/jp048234i Steel, 2003, Measuring dipolar width across liquid-liquid interfaces with molecular rulers, Nature, 424, 296, 10.1038/nature01791 Napoleon, 2006, Structural characterization of interfacial n-octanol and 3-octanol using molecular dynamic simulations, J Phys Chem B, 110, 3666, 10.1021/jp054933z Chari, 1991, Adsorption at the air/water interface from an aqueous solution of poly(vinylpyrrolidone) and sodium dodecyl sulfate, J Phys Chem, 95, 3302, 10.1021/j100161a062 Chari, 1995, Polymer-surfactant assembly at an interface, J Phys France, 5, 1421 Krishnan, 2004, Competitive adsorption at the air-water interface from a self-assembling polymer-surfactant mixture, J Phys Chem B, 108, 11442, 10.1021/jp049062s Novikov, 2017, Dual action of hydrotropes at the water/oil interface, J Phys Chem C, 121, 16423, 10.1021/acs.jpcc.7b05156 Tang, 2014, Molecular dynamics simulations of structure-property relationships of Tween 80 surfactants in water and interfaces, J Phys Chem B, 118, 12907, 10.1021/jp507499k Chanda, 2006, Molecular dynamics study of surfactant monolayers adsorbed at the oil/water and air/water interfaces, J Phys Chem B, 110, 23482, 10.1021/jp063205o Staples, 2000, Adsorption of mixed surfactants and the oil-water interface, J Phys Chem B, 106, 606, 10.1021/jp992955d Borwankar, 1988, Equilibrium and dynamics of adsorption of surfactants at fluid-fluid interface, Chem Enge Sci, 43, 1231 Ali, 2001, Surface behaviour of bile salts and tetrahydrolipstatin at air/water and oil/water interfaces, Chem Phys Lipids, 111, 73, 10.1016/S0009-3084(01)00149-9 Martinez, 2011, The intrinsic interfacial structure of ionic surfactant monolayers at water-oil and water-vapor interfaces, Proc R Soc A, 467, 1939, 10.1098/rspa.2010.0516 Scholtens, 1979, Liquid-liquid mass transfer and its retardation by macromolecular adsorption, Chem Eng Sci, 34, 661, 10.1016/0009-2509(79)85111-8 Scholtens, 1980, The influence of molecular architecture on the surface activity of vinyl alcohol-acetate copolymers, J Colloid Interface Sci, 77, 162, 10.1016/0021-9797(80)90427-0 Lundqvist, 1999, Molecular weight studies on hydroxypropyl methylcellulose II. Intrinsic viscosity, Int J Polym Anal Charact, 5, 61, 10.1080/10236669908014174 Rowe RC, Sheskey PJ, Weller PJ. Handbook of Pharmaceutical Excipients, 4th ed. Washington, DC: Pharmaceutical Press; 2003. BASF Fukasaw, 2004, Molecular weight determination of hypromellose acetate succinate (HPMCAS) using size exclusion chromatography with a multi-angle laser light scattering detector, Chem Pharm Bull (Tokyo), 52, 1391, 10.1248/cpb.52.1391 Wesselingh, 1993, Controlling diffusion, J Control Release, 24, 47, 10.1016/0168-3659(93)90167-4 Brodin, 1975, Rates of transfer of organic protolytic solutes between an aqueous and an organic phase IV. Mass transfer in the presence of surfactants, Acta Pharm Suec, 12, 41 Aragón, 2011, Solution thermodynamics of ibuprofen in aqueous media at pH 1.2 and 6.8, Lat Am J Pharm, 30, 1720