Characterization of drug-specific T cells in lamotrigine hypersensitivity

Leeder, 1998, Mechanisms of idiosyncratic hypersensitivity reactions to antiepileptic drugs, Epilepsia, 39, S8, 10.1111/j.1528-1157.1998.tb01679.x

Bocquet, 1996, Drug-induced pseudolymphoma and drug hypersensitivity syndrome (Drug Rash with Eosinophilia and Systemic Symptoms: DRESS), Semin Cutan Med Surg, 15, 250, 10.1016/S1085-5629(96)80038-1

Pichler, 2002, Cellular and molecular pathophysiology of cutaneous drug reactions, Am J Clin Dermatol, 3, 229, 10.2165/00128071-200203040-00001

Nyfeler, 1997, The lymphocyte transformation test for the diagnosis of drug allergy: sensitivity and specificity, Clin Exp Allergy, 27, 175, 10.1111/j.1365-2222.1997.tb00690.x

Hari, 2001, T cell involvement in cutaneous drug eruptions, Clin Exp Allergy, 31, 1398, 10.1046/j.1365-2222.2001.01164.x

Landsteiner, 1935, Studies on the sensitization of animals with simple chemical compounds, J Exp Med, 61, 643, 10.1084/jem.61.5.643

Naisbitt, 2000, Immunological principles of adverse drug reactions: the initiation and propagation of immune responses elicited by drug treatment, Drug Saf, 23, 483, 10.2165/00002018-200023060-00002

Park, 2001, Metabolic activation in drug allergies, Toxicology, 158, 11, 10.1016/S0300-483X(00)00397-8

Kalish, 1999, Molecular mechanisms of CD8+ T cell-mediated delayed hypersensitivity: implications for allergies, asthma, and autoimmunity, J Allergy Clin Immunol, 103, 192, 10.1016/S0091-6749(99)70489-6

Naisbitt, 2002, Covalent binding of the nitroso metabolite of sulfamethoxazole leads to toxicity and major histocompatibility complex-restricted antigen presentation, Mol Pharmacol, 62, 628, 10.1124/mol.62.3.628

Schnyder, 1997, Direct, MHC-dependent presentation of the drug sulfamethoxazole to human alphabeta T cell clones, J Clin Invest, 100, 136, 10.1172/JCI119505

von Greyerz, 1999, Interaction of sulfonamide derivatives with the TCR of sulfamethoxazole-specific human alpha beta+ T cell clones, J Immunol, 162, 595, 10.4049/jimmunol.162.1.595

Zanni, 1998, HLA-restricted, processing- and metabolism-independent pathway of drug recognition by human alpha beta T lymphocytes, J Clin Invest, 102, 1591, 10.1172/JCI3544

Zakrzewska, 1988, In vitro lymphocyte proliferation by carbamazepine, carbamazepine-10,11-epoxide, and oxcarbazepine in the diagnosis of drug-induced hypersensitivity, J Allergy Clin Immunol, 82, 110, 10.1016/0091-6749(88)90059-0

Troger, 2000, Development of a pulmonary phenytoin-associated hypersensitivity reaction despite concomitant dexamethasone and prednisolone administration, Int J Clin Pharmacol Ther, 38, 452, 10.5414/CPP38452

Kahn, 1984, Drug-induced liver injury. In vitro demonstration of hypersensitivity to both phenytoin and phenobarbital, Arch Intern Med, 144, 1677, 10.1001/archinte.144.8.1677

Mauri-Hellweg, 1995, Activation of drug-specific CD4+ and CD8+ T cells in individuals allergic to sulfonamides, phenytoin, and carbamazepine, J Immunol, 155, 462, 10.4049/jimmunol.155.1.462

Friedmann, 1994, Investigation of mechanisms in toxic epidermal necrolysis induced by carbamazepine, Arch Dermatol, 130, 598, 10.1001/archderm.1994.01690050066011

Leyva, 2000, Anticonvulsant-induced toxic epidermal necrolysis: monitoring the immunologic response, J Allergy Clin Immunol, 105, 157, 10.1016/S0091-6749(00)90191-X

Naisbitt, 2003, Hypersensitivity reactions to carbamazepine: characterization of the specificity, phenotype and cytokine profile of drug-specific T-cell clones, Mol Pharmacol, 63, 732, 10.1124/mol.63.3.732

Sachs, 1997, Lamotrigine-induced Stevens-Johnson syndrome: demonstration of specific lymphocyte reactivity in vitro, Dermatology, 195, 60, 10.1159/000245690

Britschgi, 2001, T-cell involvement in drug-induced acute generalized exanthematous pustulosis, J Clin Invest, 107, 1433, 10.1172/JCI12118

Brunner, 1968, Quantitative assay of the lytic action of immune lymphoid cells on 51Cr-labelled allogenic target cells in vitro: Inhibition by isoantibody and by drugs, Immunology, 14, 181

Schnyder, 1998, T-cell-mediated cytotoxicity against keratinocytes in sulfamethoxazole-induced skin reaction, Clin Exp Allergy, 28, 1412, 10.1046/j.1365-2222.1998.00419.x

Schnyder, 2000, Recognition of sulfamethoxazole and its reactive metabolites by drug-specific CD4+ T cells from allergic individuals, J Immunol, 164, 6647, 10.4049/jimmunol.164.12.6647

Maggs, 2000, Metabolism of lamotrigine to a reactive arene oxide intermediate, Chem Res Toxicol, 13, 1075, 10.1021/tx0000825

Shimonkevitz, 1983, Antigen recognition by H-2-restricted T cells. I. Cell-free antigen processing, J Exp Med, 158, 303, 10.1084/jem.158.2.303

Brown, 1999, Carbamazepine hypersensitivity and the use of lymphocyte proliferation responses, Dev Med Child Neurol, 41, 267, 10.1017/S0012162299000560

Schaub, 2000, Severe hypersensitivity syndrome to Lamotrigine confirmed by lymphocyte stimulation in vitro, Allergy, 55, 191, 10.1034/j.1398-9995.2000.00467.x

Dorner, 2002, MIP-1alpha, MIP-1beta, RANTES, and ATAC/lymphotactin function together with IFN-gamma as type 1 cytokines, Proc Natl Acad Sci U S A, 99, 6181, 10.1073/pnas.092141999

Van Snick, 1996, I-309/T cell activation gene-3 chemokine protects murine T cell lymphomas against dexamethasone-induced apoptosis, J Immunol, 157, 2570, 10.4049/jimmunol.157.6.2570

Pichler, 1997, High IL-5 production by human drug-specific T cell clones, Int Arch Allergy Immunol, 113, 177, 10.1159/000237539

Yawalkar, 2000, Evidence for a role for IL-5 and eotaxin in activating and recruiting eosinophils in drug-induced cutaneous eruptions, J Allergy Clin Immunol, 106, 1171, 10.1067/mai.2000.110922

Hashizume, 2002, Characterization of drug-specific T cells in phenobarbital-induced eruption, J Immunol, 168, 5359, 10.4049/jimmunol.168.10.5359

Roujeau, 1985, Lymphocyte transformation test in drug-induced toxic epidermal necrolysis, Int Arch Allergy Appl Immunol, 78, 22, 10.1159/000233856

Picker, 1990, A unique phenotype of skin-associated lymphocytes in humans. Preferential expression of the HECA-452 epitope by benign and malignant T cells at cutaneous sites, Am J Pathol, 136, 1053

Gonzalez, 1997, Expression of the cutaneous lymphocyte associated antigen in circulating T cells in drug-allergic reactions, Int Arch Allergy Immunol, 113, 345, 10.1159/000237597

Gonzalez, 1998, Participation of T lymphocytes in cutaneous allergic reactions to drugs, Clin Exp Allergy, 28, 3

Blanca, 2000, Expression of the skin-homing receptor in peripheral blood lymphocytes from subjects with nonimmediate cutaneous allergic drug reactions, Allergy, 55, 998, 10.1034/j.1398-9995.2000.00628.x

Pirmohamed, 2001, TNFalpha promoter region gene polymorphisms in carbamazepine-hypersensitive patients, Neurology, 56, 890, 10.1212/WNL.56.7.890

Wolkenstein, 1998, Covalent binding of carbamazepine reactive metabolites to P450 isoforms present in the skin, Chem Biol Interact, 113, 39, 10.1016/S0009-2797(98)00021-0

von Greyerz, 2001, Degeneracy and additional alloreactivity of drug-specific human alpha beta(+) T cell clones, Int Immunol, 13, 877, 10.1093/intimm/13.7.877

Zanni, 1999, Recognition of local anesthetics by alphabeta+ T cells, J Invest Dermatol, 112, 197, 10.1046/j.1523-1747.1999.00484.x

Wu, 2002, Two-step binding mechanism for T-cell receptor recognition of peptide MHC, Nature, 418, 552, 10.1038/nature00920