Characterization of MNK1b DNA Aptamers That Inhibit Proliferation in MDA-MB231 Breast Cancer Cells

Fukunaga, 1997, MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates, EMBO J, 16, 1921, 10.1093/emboj/16.8.1921 O'Loghlen, 2004, Identification and molecular characterization of Mnk1b, a splice variant of human MAP kinase-interacting kinase Mnk1, Exp Cell Res, 299, 343, 10.1016/j.yexcr.2004.06.006 Parra-Palau, 2003, Features in the N and C termini of the MAPK-interacting kinase Mnk1 mediate its nucleocytoplasmic shuttling, J Biol Chem, 278, 44197, 10.1074/jbc.M302398200 Morley, 1997, Involvement of stress-activated protein kinase and p38/RK mitogen-activated protein kinase signaling pathways in the enhanced phosphorylation of initiation factor 4E in NIH 3T3 cells, J Biol Chem, 272, 17887, 10.1074/jbc.272.28.17887 Flynn, 1995, Serine 209, not serine 53, is the major site of phosphorylation in initiation factor eIF-4E in serum-treated Chinese hamster ovary cells, J Biol Chem, 270, 21684, 10.1074/jbc.270.37.21684 Joshi, 1995, Phosphorylation of eukaryotic protein synthesis initiation factor 4E at Ser-209, J Biol Chem, 270, 14597, 10.1074/jbc.270.24.14597 Makkinje, 1995, Phosphorylation of eukaryotic protein synthesis initiation factor 4E by insulin-stimulated protamine kinase, J Biol Chem, 270, 14824, 10.1074/jbc.270.24.14824 Topisirovic, 2004, Phosphorylation of the eukaryotic translation initiation factor eIF4E contributes to its transformation and mRNA transport activities, Cancer Res, 64, 8639, 10.1158/0008-5472.CAN-04-2677 Phillips, 2008, MNK1 and EIF4E are downstream effectors of MEKs in the regulation of the nuclear export of HDM2 mRNA, Oncogene, 27, 1645, 10.1038/sj.onc.1210785 Proud, 2015, Mnks, eIF4E phosphorylation and cancer, Biochim Biophys Acta, 1849, 766, 10.1016/j.bbagrm.2014.10.003 Chrestensen, 2007, MNK1 and MNK2 regulation in HER2-overexpressing breast cancer lines, J Biol Chem, 282, 4243, 10.1074/jbc.M607368200 Wheater, 2010, The role of MNK proteins and eIF4E phosphorylation in breast cancer cell proliferation and survival, Cancer Biol Ther, 10, 728, 10.4161/cbt.10.7.12965 Konicek, 2011, Therapeutic inhibition of MAP kinase interacting kinase blocks eukaryotic initiation factor 4E phosphorylation and suppresses outgrowth of experimental lung metastases, Cancer Res, 71, 1849, 10.1158/0008-5472.CAN-10-3298 Furic, 2010, eIF4E phosphorylation promotes tumorigenesis and is associated with prostate cancer progression, Proc Natl Acad Sci USA, 107, 14134, 10.1073/pnas.1005320107 Wendel, 2007, Dissecting eIF4E action in tumorigenesis, Genes Dev, 21, 3232, 10.1101/gad.1604407 Ueda, 2004, Mnk2 and Mnk1 are essential for constitutive and inducible phosphorylation of eukaryotic initiation factor 4E but not for cell growth or development, Mol Cell Biol, 24, 6539, 10.1128/MCB.24.15.6539-6549.2004 Ellington, 1990, In vitro selection of RNA molecules that bind specific ligands, Nature, 346, 818, 10.1038/346818a0 Ellington, 1992, Selection in vitro of single-stranded DNA molecules that fold into specific ligand-binding structures, Nature, 355, 850, 10.1038/355850a0 Tuerk, 1990, Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase, Science, 249, 505, 10.1126/science.2200121 White, 2000, Developing aptamers into therapeutics, J Clin Invest, 106, 929, 10.1172/JCI11325 Thiel, 2009, Therapeutic applications of DNA and RNA aptamers, Oligonucleotides, 19, 209, 10.1089/oli.2009.0199 Hu, 2011, A G-quadruplex aptamer inhibits the phosphatase activity of oncogenic protein Shp2 in vitro, Chembiochem, 12, 424, 10.1002/cbic.201000470 Nagatoishi, 2011, Loop residues of thrombin-binding DNA aptamer impact G-quadruplex stability and thrombin binding, Biochimie, 93, 1231, 10.1016/j.biochi.2011.03.013 Fujita, 2013, Structural and affinity analyses of g-quadruplex DNA aptamers for camptothecin derivatives, Pharmaceuticals (Basel), 6, 1082, 10.3390/ph6091082 O'Loghlen, 2007, Characterization of the activity of human MAP kinase-interacting kinase Mnk1b, Biochim Biophys Acta, 1773, 1416, 10.1016/j.bbamcr.2007.05.009 Beggs, 2015, The MAP kinase-interacting kinases regulate cell migration, vimentin expression and eIF4E/CYFIP1 binding, Biochem J, 467, 63, 10.1042/BJ20141066 Zhou, 2013, Overexpression of HnRNP A1 promotes tumor invasion through regulating CD44v6 and indicates poor prognosis for hepatocellular carcinoma, Int J Cancer, 132, 1080, 10.1002/ijc.27742 Piekielko-Witkowska, 2010, Disturbed expression of splicing factors in renal cancer affects alternative splicing of apoptosis regulators, oncogenes, and tumor suppressors, PLoS One, 5, e13690, 10.1371/journal.pone.0013690 Tsukahara, 2013, PTB-associated splicing factor (PSF) is a PPARγ-binding protein and growth regulator of colon cancer cells, PLoS One, 8, e58749, 10.1371/journal.pone.0058749 Patel, 2013, Sprouty2, PTEN, and PP2A interact to regulate prostate cancer progression, J Clin Invest, 123, 1157, 10.1172/JCI63672 Faratian, 2011, Sprouty 2 is an independent prognostic factor in breast cancer and may be useful in stratifying patients for trastuzumab therapy, PLoS One, 6, e23772, 10.1371/journal.pone.0023772 Knauf, 2001, Negative regulation of protein translation by mitogen-activated protein kinase-interacting kinases 1 and 2, Mol Cell Biol, 21, 5500, 10.1128/MCB.21.16.5500-5511.2001 Bain, 2007, The selectivity of protein kinase inhibitors: a further update, Biochem J, 408, 297, 10.1042/BJ20070797 Wang, 2007, Inhibition of mammalian target of rapamycin induces phosphatidylinositol 3-kinase-dependent and Mnk-mediated eukaryotic translation initiation factor 4E phosphorylation, Mol Cell Biol, 27, 7405, 10.1128/MCB.00760-07 Mbatia, 2015, J Med Chem, 58, 1900, 10.1021/jm501792c Ramalingam, 2014, First MNKs degrading agents block phosphorylation of eIF4E, induce apoptosis, inhibit cell growth, migration and invasion in triple negative and Her2-overexpressing breast cancer cell lines, Oncotarget, 5, 530, 10.18632/oncotarget.1528 Santarpia, 2012, Targeting the MAPK-RAS-RAF signaling pathway in cancer therapy, Expert Opin Ther Targets, 16, 103, 10.1517/14728222.2011.645805 Bradford, 1976, A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding, Anal Biochem, 72, 248, 10.1016/0003-2697(76)90527-3 Iborra, 2004, Vaccination with a plasmid DNA cocktail encoding the nucleosomal histones of Leishmania confers protection against murine cutaneous leishmaniosis, Vaccine, 22, 3865, 10.1016/j.vaccine.2004.04.015 Ramos, 2007, A DNA aptamer population specifically detects Leishmania infantum H2A antigen, Lab Invest, 87, 409, 10.1038/labinvest.3700535 Zuker, 2003, Mfold web server for nucleic acid folding and hybridization prediction, Nucleic Acids Res, 31, 3406, 10.1093/nar/gkg595 Kikin, 2006, QGRS Mapper: a web-based server for predicting G-quadruplexes in nucleotide sequences, Nucleic Acids Res, 34, W676, 10.1093/nar/gkl253 Kanazawa, 2010, bFGF regulates PI3-kinase-Rac1-JNK pathway and promotes fibroblast migration in wound healing, PLoS One, 5, e12228, 10.1371/journal.pone.0012228