Characterization and immunostimulatory activity of a polysaccharide from the spores of Ganoderma lucidum

International Immunopharmacology - Tập 9 Số 10 - Trang 1175-1182 - 2009
Liang Guo1, Jianhui Xie2, Yuanyuan Ruan2, Lei Zhou2, Haiyan Zhu2, Xiaojing Yun2, Yan Jiang3, Lu Long3, Kangli Chen2, Zhihui Min4, Yumei Wen5, Jianxin Gu2
1Gene Research Center, Shanghai Medical College and Institutes of Biomedical Science of Fudan University, Shanghai, PR China.
2Gene Research Center, Shanghai Medical College and Institutes of Biomedical Science of Fudan University, Shanghai, 200032, PR China
3Key Laboratory of Organofluorine Chemistry Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, PR China
4Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, PR China
5Key Laboratory of Medical Molecular Virology, Institute of Medical Microbiology, Shanghai Medical College of Fudan University, Shanghai 200032, PR China

Tóm tắt

Từ khóa


Tài liệu tham khảo

Berovic, 2003, Submerged cultivation of Ganoderma lucidum biomass and immunostimulatory effects of fungal polysaccharides, J Biotechnol, 103, 77, 10.1016/S0168-1656(03)00069-5

Zhou, 2007, Ganodermataceae: natural products and their related pharmacological functions, Am J Chin Med, 35, 559, 10.1142/S0192415X07005065

Lin, 2005, Cellular and molecular mechanisms of immuno-modulation by Ganoderma lucidum, J Pharmacol Sci, 99, 144, 10.1254/jphs.CRJ05008X

Yue, 2008, Comparative studies on the immunomodulatory and antitumor activities of the different parts of fruiting body of Ganoderma lucidum and Ganoderma spores, Phytother Res, 10.1002/ptr.2478

Lin, 2006, Reishi polysaccharides induce immunoglobulin production through the TLR4/TLR2-mediated induction of transcription factor Blimp-1, J Biol Chem, 281, 24111, 10.1074/jbc.M601106200

Wang, 1997, The anti-tumor effect of Ganoderma lucidum is mediated by cytokines released from activated macrophages and T lymphocytes, Int J Cancer, 70, 699, 10.1002/(SICI)1097-0215(19970317)70:6<699::AID-IJC12>3.0.CO;2-5

Hsu, 2004, Extract of Reishi polysaccharides induces cytokine expression via TLR4-modulated protein kinase signaling pathways, J Immunol, 173, 5989, 10.4049/jimmunol.173.10.5989

Chan, 2005, Ganoderma lucidum mycelium and spore extracts as natural adjuvants for immunotherapy, J Altern Complement Med, 11, 1047, 10.1089/acm.2005.11.1047

Bao, 2002, Purification, characterization, and modification of T lymphocyte-stimulating polysaccharide from spores of Ganoderma lucidum, Chem Pharm Bull (Tokyo), 50, 623, 10.1248/cpb.50.623

Englyst, 1994, Determination of dietary fibre as non-starch polysaccharides with gas–liquid chromatographic, high-performance liquid chromatographic or spectrophotometric measurement of constituent sugars, Analyst, 119, 1497, 10.1039/AN9941901497

Hakomori, 1964, A rapid permethylation of glycolipid, and polysaccharide catalyzed by methylsulfinyl carbanion in dimethyl sulfoxide, J Biochem, 55, 205

Gantner, 2003, Collaborative induction of inflammatory responses by dectin-1 and Toll-like receptor 2, J Exp Med, 197, 1107, 10.1084/jem.20021787

Xia, 1999, Generation of recombinant fragments of CD11b expressing the functional beta-glucan-binding lectin site of CR3 (CD11b/CD18), J Immunol, 162, 7285, 10.4049/jimmunol.162.12.7285

Yan, 2003, The beta-(1->6)-branched beta-(1->3) glucohexaose and its analogues containing an alpha-(1->3)-linked bond have similar stimulatory effects on the mouse spleen as Lentinan, Int Immunopharmacol, 3, 1861, 10.1016/j.intimp.2003.09.003

Lin, 2005, Polysaccharide purified from Ganoderma lucidum induced activation and maturation of human monocyte-derived dendritic cells by the NF-kappaB and p38 mitogen-activated protein kinase pathways, J Leukoc Biol, 78, 533, 10.1189/jlb.0804481

Brown, 2002, Dectin-1 is a major beta-glucan receptor on macrophages, J Exp Med, 196, 407, 10.1084/jem.20020470

Herre, 2004, Dectin-1 and its role in the recognition of beta-glucans by macrophages, Mol Immunol, 40, 869, 10.1016/j.molimm.2003.10.007

Brown, 2003, Fungal beta-glucans and mammalian immunity, Immunity, 19, 311, 10.1016/S1074-7613(03)00233-4

Herre, 2004, The role of Dectin-1 in antifungal immunity, Crit Rev Immunol, 24, 193, 10.1615/CritRevImmunol.v24.i3.30

Adams, 2008, Differential high-affinity interaction of dectin-1 with natural or synthetic glucans is dependent upon primary structure and is influenced by polymer chain length and side-chain branching, J Pharmacol Exp Ther, 325, 115, 10.1124/jpet.107.133124

Brown, 2006, Dectin-1: a signalling non-TLR pattern-recognition receptor, Nat Rev Immunol, 6, 33, 10.1038/nri1745

Herre, 2004, Dectin-1 uses novel mechanisms for yeast phagocytosis in macrophages, Blood, 104, 4038, 10.1182/blood-2004-03-1140

Underhill, 2005, Dectin-1 activates Syk tyrosine kinase in a dynamic subset of macrophages for reactive oxygen production, Blood, 106, 2543, 10.1182/blood-2005-03-1239

Ho, 2007, Ganoderma lucidum polysaccharide peptide reduced the production of proinflammatory cytokines in activated rheumatoid synovial fibroblast, Mol Cell Biochem, 301, 173, 10.1007/s11010-006-9409-y

Sullivan, 2006, Medicinal mushrooms and cancer therapy: translating a traditional practice into Western medicine, Perspect Biol Med, 49, 159, 10.1353/pbm.2006.0034

Kidd, 2000, The use of mushroom glucans and proteoglycans in cancer treatment, Altern Med Rev, 5, 4

Volman, 2008, Dietary modulation of immune function by beta-glucans, Physiol Behav, 94, 276, 10.1016/j.physbeh.2007.11.045

Kollar, 1995, Architecture of the yeast cell wall. The linkage between chitin and beta(1 ®3)-glucan, J Biol Chem, 270, 1170, 10.1074/jbc.270.3.1170

Williams, 1992, Development of a water-soluble, sulfated (1®3)-beta-D-glucan biological response modifier derived from Saccharomyces cerevisiae, Carbohydr Res, 235, 247, 10.1016/0008-6215(92)80093-G

Akramiene, 2007, Effects of beta-glucans on the immune system, Medicina (Kaunas), 43, 597, 10.3390/medicina43080076

Gao, 2005, Antitumor activity and underlying mechanisms of ganopoly, the refined polysaccharides extracted from Ganoderma lucidum, in mice, Immunol Invest, 34, 171, 10.1081/IMM-200055813

Bao, 2001, Structural and immunological studies of a major polysaccharide from spores of Ganoderma lucidum (Fr.) Karst, Carbohydr. Res., 332, 67, 10.1016/S0008-6215(01)00075-1

Bao, 2001, Structural characterization and immunomodulating activity of a complex glucan from spores of Ganoderma lucidum, Biosci Biotechnol Biochem, 65, 2384, 10.1271/bbb.65.2384

Chen, 2007, Medicinal importance of fungal beta-(1®3), (1®6)-glucans, Mycol Res, 111, 635, 10.1016/j.mycres.2007.02.011

Ozinsky, 2000, The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between toll-like receptors, Proc Natl Acad Sci U S A, 97, 13766, 10.1073/pnas.250476497

Brown, 2001, Immune recognition. A new receptor for beta-glucans, Nature, 413, 36, 10.1038/35092620

Rice, 2002, Human monocyte scavenger receptors are pattern recognition receptors for (1®3)-beta-D-glucans, J Leukoc Biol, 72, 140, 10.1189/jlb.72.1.140

Xia, 1999, The beta-glucan-binding lectin site of mouse CR3 (CD11b/CD18) and its function in generating a primed state of the receptor that mediates cytotoxic activation in response to iC3b-opsonized target cells, J Immunol, 162, 2281, 10.4049/jimmunol.162.4.2281