Characterization and Function of 3-Hydroxy-3-Methylglutaryl-CoA Reductase in Populus trichocarpa: Overexpression of PtHMGR Enhances Terpenoids in Transgenic Poplar

Hui Wei1, Chen Xu1,2, Ali Movahedi1, Weibo Sun1, Dawei Li1, Qiang Zhuge1
1Co-Innovation Center for Sustainable Forestry in Southern China, Key Laboratory of Forest Genetics & Biotechnology, Ministry of Education, College of Biology and the Environment,, Nanjing Forestry University, Nanjing, China
2Jiangsu Provincial Key Construction Laboratory of Special Biomass Resource Utilization, Nanjing Xiaozhuang University, Nanjing, China

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Alborn, 2007, Disulfooxy fatty acids from the American bird grasshopper Schistocerca americana, elicitors of plant volatiles, Proc. Natl. Acad. Sci. United States America, 104, 12976, 10.1073/pnas.0705947104

Akhtar, 2013, Cloning and functional characterization of 3-hydroxy-3-methylglutaryl coenzyme A reductase gene from Withania somnifera: an important medicinal plant, Protoplasma, 250, 613, 10.1007/s00709-012-0450-2

Ayora-Talavera, 2002, Overexpression in Catharanthus roseus, hairy roots of a truncated hamster 3-hydroxy-3-methylglutaryl-coA reductase gene, Appl. Biochem. Biotechnol., 97, 135, 10.1385/ABAB:97:2:135

Bach, 1983, Inhibition by mevinolin of plant growth, sterol formation and pigment accumulation, Physiolog. Plantarum, 59, 50, 10.1111/j.1399-3054.1983.tb06570.x

Bischoff, 1996, 3-Hydroxy-3-methylglutaryl-coenzyme A reductase from Haloferax volcanii: purification, characterization, and expression in Escherichia coli, J. Bacteriol., 178, 19, 10.1128/jb.178.1.19-23.1996

Bouvier, 2005, Biogenesis, molecular regulation, and function of plant isoprenoids, Prog. In Lipid Res., 44, 357, 10.1016/j.plipres.2005.09.003

Cao, 2010, Molecular cloning, characterization and function analysis of the gene encoding HMG-CoA reductase from Euphorbia pekinensis rupr, Mol. Biol. Rep., 37, 1559, 10.1007/s11033-009-9558-7

Choi, 1992, Differential induction and suppression of potato 3-hydroxy-3-methylglutaryl coenzyme A reductase genes in response to Phytophthora infestans and to its elicitor arachidonic acid, Plant Cell, 4, 1333, 10.1105/tpc.4.10.1333

Cowan, 2001, Fruit size: towards an understanding of the metabolic control of fruit growth using avocado as a model system, Physiolog. Plantarum, 111, 127, 10.1034/j.1399-3054.2001.1110201.x

Dai, 2011, Cloning and characterization of a novel 3-hydroxy-3-methylglutaryl coenzyme A reductase gene from Salvia miltiorrhiza, involved in diterpenoid tanshinone accumulation, J. Plant Physiol., 168, 148, 10.1016/j.jplph.2010.06.008

Dong, 2013, Overexpression of 3-hydroxy-3-methylglutaryl coenzyme A reductase in Parthenium argentatum (guayule), Industrial Crops Prod., 46, 15, 10.1016/j.indcrop.2012.12.044

Eapen, 2005, Prospects of genetic engineering of plants for phytoremediation of toxic metals, Biotechnol. Adv., 23, 97, 10.1016/j.biotechadv.2004.10.001

Eisenreich, 2001, Deoxyxylulose phosphate pathway to terpenoids, Trends In Plant Sci., 6, 78, 10.1016/S1360-1385(00)01812-4

Enfissi, 2010, Metabolic engineering of the mevalonate and non-mevalonate isopentenyl diphosphate-forming pathways for the production of health-promoting isoprenoids in tomato, Plant Biotechnol. J., 3, 17, 10.1111/j.1467-7652.2004.00091.x

Estévez, 2001, 1-Deoxy-D-xylulose-5-phosphate synthase, a limiting enzyme for plastidic isoprenoid biosynthesis in plants, J. Biol. Chem., 276, 22901, 10.1074/jbc.M100854200

Finkelstein, 2013, Abscisic acid synthesis and response, Arabidopsis Book/American Soc. Plant Biolog., 11, 10.1199/tab.0166

Goldstein, 1990, Regulation of the mevalonate pathway, Nat., 343, 425, 10.1038/343425a0

Grassmann, 2002, Plant’s defense and its benefits for animals and medicine: the role of phenolics and terpenoids in avoiding oxygen stress, Plant Physiol. Biochem., 471

Hemmerlin, 1998, Effects of mevinolin on cell cycle progression and viability of tobacco BY-2 cells, Plant J., 14, 65, 10.1046/j.1365-313X.1998.00095.x

Hemmerlin, 2013, Post-translational events and modifications regulating plant enzymes involved in isoprenoid precursor biosynthesis, Plant Sci., 203, 41, 10.1016/j.plantsci.2012.12.008

Heuston, 2012, HmgR, a key enzyme in the mevalonate pathway for isoprenoid biosynthesis, is essential for the growth of Listeria monocytogenes EDGe, Microbiol., 1684

Hunter, 2007, The non-mevalonate pathway of isoprenoid precursor biosynthesis, J. Biol. Chem., 282, 21573, 10.1074/jbc.R700005200

Istvan, 2000, Crystal structure of the catalytic portion of human HMG-CoA reductase: insights into the regulation of activity and catalysis, EMBO J., 19, 819, 10.1093/emboj/19.5.819

Jiang, 2006, Molecular cloning of a HMG-CoA reductase gene from Eucommia ulmoides oliver, Biosci. Rep., 26, 171, 10.1007/s10540-006-9010-3

Kim, 2014, Functional analysis of HMGR encoding genes in triterpene saponin-producing Panax ginseng Meyer, Plant Physiol., 165, 373, 10.1104/pp.113.222596

Kirby, 2009, Biosynthesis of plant isoprenoids: perspectives for microbial engineering, Annu. Rev. Plant Biol., 60, 335, 10.1146/annurev.arplant.043008.091955

Leivar, 2011, Modulation of plant HMG-CoA reductase by protein phosphatase 2a, Plant Signaling Behav., 6, 1127, 10.4161/psb.6.8.16363

Li, 2014, Species-specific expansion and molecular evolution of the 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMGR) gene family in plants, PloS One, 9, 10.1371/journal.pone.0094172

Liao, 2018, Improved fruit α-tocopherol, carotenoid, squalene and phytosterol content through manipulation of Brassica juncea 3-hydroxy-3-methylglutaryl-CoA synthase1 in transgenic tomato, Plant Biotechnol. J., 16, 784, 10.1111/pbi.12828

Liao, 2014, Past achievements, current status and future perspectives of studies on 3-hydroxy-3-methylglutaryl-CoA synthase (HMGS) in the mevalonate (MVA) pathway, Plant Cell Rep., 33, 1005, 10.1007/s00299-014-1592-9

Liao, 2004, Cloning and characterisation of the gene encoding HMG-CoA reductase from Taxus media and its functional identification in yeast, Funct. Plant Biol., 31, 785, 10.1071/FP03153

Lin, 2011, Enhancement of artemisinin content in tetraploid Artemisia annua plants by modulating the expression of genes in the artemisinin biosynthetic pathway, Biotechnol. Appl. Biochem., 58, 50, 10.1002/bab.13

Lois, 2010, Carotenoid biosynthesis during tomato fruit development: regulatory role of 1-deoxy-d-xylulose 5-phosphate synthase, Plant J., 22, 503, 10.1046/j.1365-313x.2000.00764.x

Luo, 2013, Cloning and expression analysis of a key device of HMGR gene involved in ginsenoside biosynthesis of Panax ginseng via synthetic biology approach, Acta Pharm. Sin., 48, 219

Maldonado-Mendoza, 1992, Nucleotide sequence of a cDNA encoding 3-hydroxy-3-methylglutaryl coenzyme A reductase from Catharanthus roseus, Plant Physiol., 100, 1613, 10.1104/pp.100.3.1613

Marmiroli, 2011, Growth, physiological and molecular traits in Salicaceae trees investigated for phytoremediation of heavy metals and organics, Tree Physiol., 31, 1319, 10.1093/treephys/tpr090

Mashiguchi, 2011, The main auxin biosynthesis pathway in Arabidopsis, Proc. Natl. Acad. Sci., 108, 18512, 10.1073/pnas.1108434108

Matthews, 2000, Metabolic engineering of carotenoid accumulation in Escherichia coli by modulation of the isoprenoid precursor pool with expression of deoxyxylulose phosphate synthase, Appl. Microbiol. Biotechnol., 53, 396, 10.1007/s002530051632

Maurey, 1986, 3-Hydroxy-3-methylglutaryl coenzyme A reductase activity in Ochromonas malhamensis: a system to study the relationship between enzyme activity and rate of steroid biosynthesis, Plant Physiol., 82, 523, 10.1104/pp.82.2.523

Morris, 2011, Utilisation of the MVA pathway to produce elevated levels of the sesquiterpene α-copaene in potato tubers, Phytochem., 72, 2288, 10.1016/j.phytochem.2011.08.023

Movahedi, 2015, Expression of the chickpea CarNAC3, gene enhances salinity and drought tolerance in transgenic poplars, Plant Cell Tissue Organ Culture, 120, 141, 10.1007/s11240-014-0588-z

Ozga, 2009, Developmental and hormonal regulation of gibberellin biosynthesis and catabolism in pea fruit, Plant Physiol., 150, 448, 10.1104/pp.108.132027

Pan, 2009, Molecular cloning, characterization and expression analysis of a new gene encoding 3-hydroxy-3-methylglutaryl coenzyme A reductase from Salvia miltiorrhiza, Acta Physiolog. Plantarum, 31, 565, 10.1007/s11738-008-0266-z

Qiu, 2014, Cloning and characterization of an elicitor-responsive gene encoding 3-hydroxy-3-methylglutaryl coenzyme A reductase involved in 20-hydroxyecdysone production in cell cultures of Cyanotis arachnoidea, Plant Physiol. Biochem., 84, 1, 10.1016/j.plaphy.2014.08.021

Reinecke, 2013, Gibberellin 3-oxidase gene expression patterns influence gibberellin biosynthesis, growth, and development in pea, Plant Physiol., 163, 929, 10.1104/pp.113.225987

Rohmer, 1996, Glyceraldehyde 3-phosphate and pyruvate as precursors of isoprenic units in an alternative non-mevalonate pathway for terpenoid biosynthesis, J. Am. Chem. Soc., 118, 2564, 10.1021/ja9538344

Schaller, 1995, Expression of the Hevea brasiliensis (HBK) Mull. Arg. 3-hydroxy-3-methylglutaryl-coenzyme A reductase 1 in tobacco results in sterol overproduction, Plant Physiol., 109, 770, 10.1104/pp.109.3.761

Shen, 2006, Cloning and characterization of a root-specific expressing gene encoding 3-hydroxy-3-methylglutaryl coenzyme A reductase from Gingko biloba, Mol. Biol. Rep., 33, 117, 10.1007/s11033-006-0014-7

Suzuki, 2005, Loss of function of 3-hydroxy-3-methylglutaryl coenzyme A reductase 1 (HMGR1) in Arabidopsis leads to dwarfing, early senescence and male sterility, and reduced sterol levels, Plant J., 20, 67, 10.1111/j.1365-313X.2004.02003.x

Suzuki, 2007, Molecular genetics of plant sterol backbone synthesis, Lipids, 42, 47, 10.1007/s11745-006-1000-5

Ton, 2009, The multifaceted role of ABA in disease resistance, Trends In Plant Sci., 14, 310, 10.1016/j.tplants.2009.03.006

Tuskan, 2006, The genome of black cottonwood, Populus trichocarpa (Torr. & Gray), Sci., 313, 1596, 10.1126/science.1128691

Uthup, 2013, Impact of an intragenic retrotransposon on the structural integrity and evolution of a major isoprenoid biosynthesis pathway gene in Hevea brasiliensis, Plant Physiol. Biochem., 73, 176, 10.1016/j.plaphy.2013.09.004

Wang, 2007, Molecular cloning and functional analysis of the gene encoding 3-hydroxy-3-methylglutaryl coenzyme A reductase from hazel (Corylus avellana L. Gasaway), J. Biochem. Mol. Biol., 40, 861, 10.5483/BMBRep.2007.40.6.861

Wu, 1997, Tetranortriterpenoid insect antifeedants from Severinia buxifolia, Phytochem., 45, 1393, 10.1016/S0031-9422(97)00176-3

Xu, 2012, Enhancement of ganoderic acid accumulation by overexpression of an n-terminally truncated 3-hydroxy-3-methylglutaryl coenzyme A reductase gene in the basidiomycete Ganoderma lucidum, Appl. Environ. Microbiol., 78, 7968, 10.1128/AEM.01263-12

Yang, 2012, PEG and ABA trigger methyl jasmonate accumulation to induce the MEP pathway and increase tanshinone production in Salvia miltiorrhiza hairy roots, Physiolog. Plantarum, 146, 173, 10.1111/j.1399-3054.2012.01603.x

Zhang, 2013, Genome-wide analysis of the populus hsp90 gene family reveals differential expression patterns, localization, and heat stress responses, BMC Genomics, 14, 532, 10.1186/1471-2164-14-532