Characterisation by molecular cloning of two genes from Streptomyces verticillus encoding resistance to bleomycin

Carter, 1990, A role for the metal binding domain in determining the DNA sequence selectivity of Fe-bleomycin, J. Biol. Chem., 265, 4193, 10.1016/S0021-9258(19)39544-4 Desomer, 1990, Transformation of Rhodococcus fascians by high-voltage electroporation and development of R. fascians cloning vectors, Appl. Environ. Microbiol., 56, 2818, 10.1128/AEM.56.9.2818-2825.1990 Drocourt, 1990, Cassettes of the Streptoalloteichus hindustanus ble gene for transformation of lower and higher eukaryotes to phleomycin resistance, Nucleic Acids Res., 18, 4009, 10.1093/nar/18.13.4009 Dumas, 1994, Crystal structure and site-directed mutagenesis of a bleomycin resistance protein and their significance for drug sequencing, EMBO J., 13, 2483, 10.1002/j.1460-2075.1994.tb06535.x Gatignol, 1988, Bleomycin resistance conferred by a drug-binding protein, FEBS Lett., 230, 171, 10.1016/0014-5793(88)80665-3 Genilloud, 1984, The transposon Tn5 carries a bleomycin resistance determinant, Gene, 32, 225, 10.1016/0378-1119(84)90050-7 Hopwood, 1985 Iitaka, 1978, Chemistry of bleomycin, XX. The x-ray structure determination of P-3A Cu (II) -complex, a biosynthetic interme- diate of bleomycin, J. Antibiot., 31, 1070, 10.7164/antibiotics.31.1070 Katz, 1983, Cloning and expression of the tyrosinase gene from Streptomyces antibioticus in Streptomyces lividans, J. Gen. Microbiol., 129, 2703 Mania, 1988, An Escherichia coli vector to express and purify foreign proteins by fusion to and separation from maltose-binding protein, Gene, 74, 365, 10.1016/0378-1119(88)90170-9 Mazodier, 1985, Completion of the nucleotide sequence of the central region of Tn5 confirms the presence of three resistance genes, Nucleic Acids Res., 13, 195, 10.1093/nar/13.1.195 Semon, 1987, Plasmid-determined bleomycin resistance in Staphylococcus aureus, Plasmid, 17, 46, 10.1016/0147-619X(87)90007-2 Sugiyama, 1985, Mechanism of self-protection in a puromycin-producing micro-organism, J. Gen. Microbiol., 131, 1999 Sugiyama, 1994, Inactivation of bleomycin by an N-acetyltransferase in the bleoraycin-producing strain Streptomyces verticillus, FEMS Microbiol. Lett., 121, 81, 10.1111/j.1574-6968.1994.tb07079.x Umezawa, 1975, Bleomycin, Vol. III, 21