Chaotic neovascularization induced by aggressive fibrosarcoma cells overexpressing S-adenosylmethionine decarboxylase

Aino Paasinen-Sohns1, Essi Kääriäinen1, Miao Yin1, Kristiina Järvinen1, Pirjo Nummela1, Erkki Hölttä1
1Haartman Institute, Department of Pathology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland

Tài liệu tham khảo

Auvinen, 1992, Ornithine decarboxylase activity is critical for cell transformation, Nature, 360, 355, 10.1038/360355a0 Auvinen, 1995, Ornithine decarboxylase- and ras-induced cell transformations: reversal by protein tyrosine kinase inhibitors and role of pp130CAS, Mol Cell Biol, 15, 6513, 10.1128/MCB.15.12.6513 Auvinen, 1997, Human ornithine decarboxylase-overproducing NIH3T3 cells induce rapidly growing, highly vascularized tumors in nude mice, Cancer Res, 57, 3016 Bergers, 2000, Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis, Nat Cell Biol, 2, 737, 10.1038/35036374 Bergers, 2003, Tumorigenesis and the angiogenic switch, Nat Rev Cancer, 3, 401, 10.1038/nrc1093 Bouck, 1996, How tumors become angiogenic, Adv Cancer Res, 69, 135, 10.1016/S0065-230X(08)60862-3 Brown, 1990, Independent expression and cellular processing of Mr 72,000 type IV collagenase and interstitial collagenase in human tumorigenic cell lines, Cancer Res, 50, 6184 Carew, 2008, The novel polyamine analogue CGC-11093 enhances the antimyeloma activity of bortezomib, Cancer Res, 68, 4783, 10.1158/0008-5472.CAN-07-6483 Carmeliet, 2000, Angiogenesis in cancer and other diseases, Nature, 407, 249, 10.1038/35025220 Carmeliet, 2005, VEGF as a key mediator of angiogenesis in cancer, Oncology, 69, 4, 10.1159/000088478 Casero, 2007, Targeting polyamine metabolism and function in cancer and other hyperproliferative diseases, Nat Rev Drug Discov, 6, 373, 10.1038/nrd2243 Castle, 1993, High level thrombospondin 1 expression in two NIH 3T3 cloned lines confers serum- and anchorage-independent growth, J Biol Chem, 268, 2899, 10.1016/S0021-9258(18)53858-8 Chang, 2000, Mosaic blood vessels in tumors: frequency of cancer cells in contact with flowing blood, Proc Natl Acad Sci USA, 97, 14608, 10.1073/pnas.97.26.14608 Christian, 2008, Endosialin (Tem1) is a marker of tumor-associated myofibroblasts and tumor vessel-associated mural cells, Am J Pathol, 172, 486, 10.2353/ajpath.2008.070623 Dameron, 1994, The p53 tumor suppressor gene inhibits angiogenesis by stimulating the production of thrombospondin, Cold Spring Harb Symp Quant Biol, 59, 483, 10.1101/SQB.1994.059.01.053 de Fraipont, 2001, Thrombospondins and tumor angiogenesis, Trends Mol Med, 7, 401, 10.1016/S1471-4914(01)02102-5 di Tomaso, 2005, Mosaic tumor vessels: cellular basis and ultrastructure of focal regions lacking endothelial cell markers, Cancer Res, 65, 5740, 10.1158/0008-5472.CAN-04-4552 Egeblad, 2002, New functions for the matrix metalloproteinases in cancer progression, Nat Rev Cancer, 2, 161, 10.1038/nrc745 Fang, 2000, Matrix metalloproteinase-2 is required for the switch to the angiogenic phenotype in a tumor model, Proc Natl Acad Sci USA, 97, 3884, 10.1073/pnas.97.8.3884 Ferrara, 2000, VEGF: an update on biological and therapeutic aspects, Curr Opin Biotechnol, 11, 617, 10.1016/S0958-1669(00)00153-1 Ferrara, 2005, Angiogenesis as a therapeutic target, Nature, 438, 967, 10.1038/nature04483 Folberg, 2000, Vasculogenic mimicry and tumor angiogenesis, Am J Pathol, 156, 361, 10.1016/S0002-9440(10)64739-6 Folberg, 2004, Vasculogenic mimicry, APMIS, 112, 508, 10.1111/j.1600-0463.2004.apm11207-0810.x Folberg, 2006, Tumor cell plasticity in uveal melanoma: microenvironment directed dampening of the invasive and metastatic genotype and phenotype accompanies the generation of vasculogenic mimicry patterns, Am J Pathol, 169, 1376, 10.2353/ajpath.2006.060223 Folkman, 2006, Angiogenesis, Annu RevMed, 57, 1, 10.1146/annurev.med.57.121304.131306 Hanahan, 1996, Patterns and emerging mechanisms of the angiogenic switch during tumorigenesis, Cell, 86, 353, 10.1016/S0092-8674(00)80108-7 Handsley, 2005, Metalloproteinases and their inhibitors in tumor angiogenesis, Int J Cancer, 115, 849, 10.1002/ijc.20945 Hato, 2008, The role of angiopoietin-like proteins in angiogenesis and metabolism, Trends Cardiovasc Med, 18, 6, 10.1016/j.tcm.2007.10.003 Heby, 1990, Molecular genetics of polyamine synthesis in eukaryotic cells, Trends Biochem Sci, 15, 153, 10.1016/0968-0004(90)90216-X Hillen, 2007, Tumour vascularization: sprouting angiogenesis and beyond, Cancer Metastasis Rev, 26, 489, 10.1007/s10555-007-9094-7 Holtta, 1998, Cell transformation by ornithine decarboxylase is associated with phosphorylation of the transactivation domain of c-jun, Biochem Soc Trans, 26, 621, 10.1042/bst0260621 Humtsoe, 2003, Regulation of cell-cell interactions by phosphatidic acid phosphatase 2b/VCIP, EMBO J, 22, 1539, 10.1093/emboj/cdg165 Jones, 2000, The tenascin family of ECM glycoproteins: structure, function, and regulation during embryonic development and tissue remodeling, Dev Dyn, 218, 235, 10.1002/(SICI)1097-0177(200006)218:2<235::AID-DVDY2>3.0.CO;2-G Kaariainen, 2006, Switch to an invasive growth phase in melanoma is associated with tenascin-C, fibronectin, and procollagen-I forming specific channel structures for invasion, J Pathol, 210, 181, 10.1002/path.2045 Kazerounian, 2008, Thrombospondins in cancer, Cell Mol Life Sci, 65, 700, 10.1007/s00018-007-7486-z Kielosto, 2004, Reversible regulation of the transformed phenotype of ornithine decarboxylase- and ras-overexpressing cells by dominant-negative mutants of c-jun, Cancer Res, 64, 3772, 10.1158/0008-5472.CAN-3188-2 Kielosto, 2009, Identification of integrins alpha6 and beta7 as c-jun- and transformation-relevant genes in highly invasive fibrosarcoma cells, Int J Cancer, 125, 1065, 10.1002/ijc.24391 Kucharzewska, 2010, Ornithine decarboxylase and extracellular polyamines regulate microvascular sprouting and actin cytoskeleton dynamics in endothelial cells, Exp Cell Res, 316, 2683, 10.1016/j.yexcr.2010.05.033 Lan, 2000, Inhibition of ornithine decarboxylase (ODC) decreases tumor vascularization and reverses spontaneous tumors in ODC/Ras transgenic mice, Cancer Res, 60, 5696 MacFadyen, 2005, Endosialin (TEM1, CD248) is a marker of stromal fibroblasts and is not selectively expressed on tumour endothelium, FEBS Lett, 579, 2569, 10.1016/j.febslet.2005.03.071 Medina, 2007, Challenges of antiangiogenic cancer therapy: trials and errors, and renewed hope, J Cell Mol Med, 11, 374, 10.1111/j.1582-4934.2007.00056.x Morgenstern, 1990, Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line, Nucleic Acids Res, 18, 3587, 10.1093/nar/18.12.3587 Nanda, 2006, Tumor endothelial marker 1 (Tem1) functions in the growth and progression of abdominal tumors, Proc Natl Acad Sci USA, 103, 3351, 10.1073/pnas.0511306103 Nozawa, 2006, Infiltrating neutrophils mediate the initial angiogenic switch in a mouse model of multistage carcinogenesis, Proc Natl Acad Sci USA, 103, 12493, 10.1073/pnas.0601807103 Nummela, 2006, Thymosin beta4 is a determinant of the transformed phenotype and invasiveness of S-adenosylmethionine decarboxylase-transfected fibroblasts, Cancer Res, 66, 701, 10.1158/0008-5472.CAN-05-2421 Nyberg, 2005, Endogenous inhibitors of angiogenesis, Cancer Res, 65, 3967, 10.1158/0008-5472.CAN-04-2427 Orend, 2006, Tenascin-C induced signaling in cancer, Cancer Lett, 244, 143, 10.1016/j.canlet.2006.02.017 O’Rourke, 1992, Thrombospondin 1 and thrombospondin 2 are expressed as both homo- and heterotrimers, J Biol Chem, 267, 24921, 10.1016/S0021-9258(19)73983-0 Paasinen-Sohns, 1997, Cells transformed by ODC, c-HA-ras and v-src exhibit MAP kinase/Erk-independent constitutive phosphorylation of Sos, Raf and c-Jun activation domain, and reduced PDGF receptor expression, Oncogene, 15, 1953, 10.1038/sj.onc.1201366 Paasinen-Sohns, 2000, c-Jun activation-dependent tumorigenic transformation induced paradoxically by overexpression or block of S-adenosylmethionine decarboxylase, J Cell Biol, 151, 801, 10.1083/jcb.151.4.801 Papetti, 2002, Mechanisms of normal and tumor-derived angiogenesis, Am J Physiol Cell Physiol, 282, C947, 10.1152/ajpcell.00389.2001 Pegg, 1988, Polyamine metabolism and its importance in neoplastic growth and a target for chemotherapy, Cancer Res, 48, 759 Ravanko, 2000, Loss of p27Kip1 from cyclin E/cyclin-dependent kinase (CDK) 2 but not from cyclin D1/CDK4 complexes in cells transformed by polyamine biosynthetic enzymes, Cancer Res, 60, 5244 Ravanko, 2004, Cysteine cathepsins are central contributors of invasion by cultured adenosylmethionine decarboxylase-transformed rodent fibroblasts, Cancer Res, 64, 8831, 10.1158/0008-5472.CAN-03-2993 Ren, 2006, Regulation of tumor angiogenesis by thrombospondin-1, Biochim Biophys Acta, 1765, 178 Rettig, 1992, Identification of endosialin, a cell surface glycoprotein of vascular endothelial cells in human cancer, Proc Natl Acad Sci USA, 89, 10832, 10.1073/pnas.89.22.10832 Roberts, 1996, Regulation of tumor growth and metastasis by thrombospondin-1, FASEB J, 10, 1183, 10.1096/fasebj.10.10.8751720 Sheibani, 1995, Thrombospondin 1 expression in transformed endothelial cells restores a normal phenotype and suppresses their tumorigenesis, Proc Natl Acad Sci USA, 92, 6788, 10.1073/pnas.92.15.6788 Sistonen, 1989, Activation of the neu tyrosine kinase induces the fos/jun transcription factor complex, the glucose transporter and ornithine decarboxylase, J Cell Biol, 109, 1911, 10.1083/jcb.109.5.1911 Slack, 1994, Transformation by v-src causes transient induction followed by repression of mouse thrombospondin-1, Cell Growth Differ, 5, 1373 Soikkeli, 2007, Systematic search for the best gene expression markers for melanoma micrometastasis detection, J Pathol, 213, 180, 10.1002/path.2229 St Croix, 2000, Genes expressed in human tumor endothelium, Science, 289, 1197, 10.1126/science.289.5482.1197 Streit, 1999, Thrombospondin-2: a potent endogenous inhibitor of tumor growth and angiogenesis, Proc Natl Acad Sci USA, 96, 14888, 10.1073/pnas.96.26.14888 Strongin, 2010, Proteolytic and non-proteolytic roles of membrane type-1 matrix metalloproteinase in malignancy, Biochim Biophys Acta, 1803, 133, 10.1016/j.bbamcr.2009.04.009 Svensson, 1997, CGP 48664, a potent and specific S-adenosylmethionine decarboxylase inhibitor: effects on regulation and stability of the enzyme, Biochem J, 322, 297, 10.1042/bj3220297 Svensson, 2008, Hypoxia-mediated induction of the polyamine system provides opportunities for tumor growth inhibition by combined targeting of vascular endothelial growth factor and ornithine decarboxylase, Cancer Res, 68, 9291, 10.1158/0008-5472.CAN-08-2340 Takigawa, 1990, Tumor angiogenesis and polyamines: alpha-difluoromethylornithine, an irreversible inhibitor of ornithine decarboxylase, inhibits B16 melanoma-induced angiogenesis in ovo and the proliferation of vascular endothelial cells in vitro, Cancer Res, 50, 4131 Takigawa, 1990, Induction of angiogenesis in chick yolk-sac membrane by polyamines and its inhibition by tissue inhibitors of metalloproteinases (TIMP and TIMP-2), Biochem Biophys Res Commun, 171, 1264, 10.1016/0006-291X(90)90822-5 Talts, 1998, Expansion of the nonadherent myeloid cell population by monoclonal antibodies against tenascin-C in murine long-term bone marrow cultures, Exp Hematol, 26, 552 Tikhonenko, 1996, Viral myc oncoproteins in infected fibroblasts down-modulate thrombospondin-1, a possible tumor suppressor gene, J Biol Chem, 271, 30741, 10.1074/jbc.271.48.30741 Toft, 2001, Reactivation of proliferin gene expression is associated with increased angiogenesis in a cell culture model of fibrosarcoma tumor progression, Proc Natl Acad Sci USA, 98, 13055, 10.1073/pnas.231364798 Vollmer, 1997, Biologic and oncologic implications of tenascin-C/hexabrachion proteins, Crit Rev Oncol Hematol, 25, 187, 10.1016/S1040-8428(97)00004-8 Volpert, 1998, A human fibrosarcoma inhibits systemic angiogenesis and the growth of experimental metastases via thrombospondin-1, Proc Natl Acad Sci USA, 95, 6343, 10.1073/pnas.95.11.6343 Wallace, 2007, Targeting polyamine metabolism: a viable therapeutic/preventative solution for cancer?, Expert Opin Pharmacother, 8, 2109, 10.1517/14656566.8.13.2109 Watnick, 2003, Ras modulates myc activity to repress thrombospondin-1 expression and increase tumor angiogenesis, Cancer Cell, 3, 219, 10.1016/S1535-6108(03)00030-8 Weinstat-Saslow, 1994, Transfection of thrombospondin 1 complementary DNA into a human breast carcinoma cell line reduces primary tumor growth, metastatic potential, and angiogenesis, Cancer Res, 54, 6504 Yang, 2007, Thrombospondin-1 peptide ABT-510 combined with valproic acid is an effective antiangiogenesis strategy in neuroblastoma, Cancer Res, 67, 1716, 10.1158/0008-5472.CAN-06-2595 Zabrenetzky, 1994, Expression of the extracellular matrix molecule thrombospondin inversely correlates with malignant progression in melanoma, lung and breast carcinoma cell lines, Int J Cancer, 59, 191, 10.1002/ijc.2910590209 Zhang, 2007, Thrombospondin-based antiangiogenic therapy, Microvasc Res, 74, 90, 10.1016/j.mvr.2007.04.007 Zhang, 2003, Hepatocyte growth factor/scatter factor mediates angiogenesis through positive VEGF and negative thrombospondin 1 regulation, Proc Natl Acad Sci USA, 100, 12718, 10.1073/pnas.2135113100