Changing the locks on intestinal signaling

Basu, 2014, Intestinal cell proliferation and senescence are regulated by receptor guanylyl cyclase C and p21, J. Biol. Chem., 289, 581, 10.1074/jbc.M113.511311 Carey, 2021, Diarrheal pathogens trigger rapid evolution of the guanylate cyclase-C signaling axis in bats, Cell Host Microbe, 29, 1342, 10.1016/j.chom.2021.07.005 Khalil, 2018, Morbidity and mortality due to shigella and enterotoxigenic Escherichia coli diarrhoea: the Global Burden of Disease Study 1990-2016, Lancet Infect. Dis., 18, 1229, 10.1016/S1473-3099(18)30475-4 Marx, 1998, One peptide, two topologies: structure and interconversion dynamics of human uroguanylin isomers, J. Pept. Res., 52, 229, 10.1111/j.1399-3011.1998.tb01480.x Pitari, 2003, Bacterial enterotoxins are associated with resistance to colon cancer, Proc. Natl. Acad. Sci. USA, 100, 2695, 10.1073/pnas.0434905100 Schulz, 1990, Guanylyl cyclase is a heat-stable enterotoxin receptor, Cell, 63, 941, 10.1016/0092-8674(90)90497-3 Steinbrecher, 2011, Transmembrane guanylate cyclase in intestinal pathophysiology, Curr. Opin. Gastroenterol., 27, 139, 10.1097/MOG.0b013e328341ead5 Zambon, 2005, Gene expression patterns define key transcriptional events in cell-cycle regulation by cAMP and protein kinase A, Proc. Natl. Acad. Sci. USA, 102, 8561, 10.1073/pnas.0503363102 Zegeye, 2019, Development of an enterotoxigenic Escherichia coli vaccine based on the heat-stable toxin, Hum. Vaccin. Immunother., 15, 1379, 10.1080/21645515.2018.1496768 Zhao, 2005, Cyclic GMP-dependent protein kinase regulates CCAAT enhancer-binding protein beta functions through inhibition of glycogen synthase kinase-3, J. Biol. Chem., 280, 32683, 10.1074/jbc.M505486200