Changes of serum amyloid A, haptoglobin, ceruloplasmin, fibrinogen, and lipid-associated sialic acid in sheep fed high grain rations with altered digestive functions
Tóm tắt
Changes of serum amyloid A (SAA), haptoglobin (Hp), ceruloplasmin, fibrinogen, and lipid-associated sialic acid (LSA) were assessed in sheep fed high grain rations with negative alterations of digestive functions. During a period of 30 days (divided into three equal steps), eight Karakul lambs were divided into a control (n = 4) and an experiment group (n = 4). The control group was fed a ration consisting of 80% alfalfa hay and 20% wheat straw for the whole period of the study. In the experiment group, ground barley was substituted for 40% of the ration for the first step (10 days) and 62.5% of the ration for the rest of the study (20 days). Negative alterations of digestive functions (decreased rumen pH, reduced feces consistency and dry matter, and reduced feed intake) were evidenced in the experiment group after day 10. On day 0 (beginning of the study) and days 8 and 10 of each step, serum (for SAA, HP, ceruloplasmin, and LSA) and plasma samples (for fibrinogen) were collected from jugular vein. The averages of the eighth and tenth days were used for statistical study. SAA increased in both groups from day 10 afterwards. This increase was significant (P < 0.05) in the experiment group on day 20. Great variations were observed in the concentrations of SAA in individual sheep of the control group. On day 20, the concentration of SAA was significantly higher in the experiment group than that of the control sheep (P < 0.05). HP increased in both groups from day 10 with sharp rises on day 20 (P < 0.05 in the experiment group). Great variations were obvious in the control group on days 20 and 30. Ceruloplasmin, fibrinogen, and LSA were almost constant at various stages of the study with no significant difference between groups. The results reveal that, unlike SAA and HP, levels of ceruloplasmin, fibrinogen, and LSA may not be affected by high grain rations, digestive disorders such as SARA and/or the confounding parameters such as stress. More investigations with larger numbers of animals and focusing on specific markers for stress are suggested for precise differentiations.
Tài liệu tham khảo
citation_journal_title=Vet Q; citation_title=Influence of physical stress on the plasma concentrations of serum amyloid A (SAA) and haptoglobin (Hp) in calves; citation_author=SPM Alsemgeest, IE Lambooy, HK Wierenga, SJ Dieleman, B Meerkerk, AM Ederen, TA Niewold; citation_volume=17; citation_publication_date=1995; citation_pages=9-12; citation_id=CR1
citation_journal_title=J Anim Sci; citation_title=Effect of feeding regimen on concentration of free endotoxin in ruminal fluid of cattle; citation_author=PH Andersen, B Bergelin, KA Christensen; citation_volume=72; citation_publication_date=1994; citation_pages=487-491; citation_id=CR2
citation_journal_title=J Anim Sci; citation_title=Effect of transportation and commingling on the acute-phase protein response, growth, and feed intake in newly weaned beef calves; citation_author=JD Arthington, SD Eicher, WE Kunkle, FG Martin; citation_volume=81; citation_publication_date=2003; citation_pages=1120-1125; citation_id=CR3
citation_journal_title=Immunol Today; citation_title=The acute phase response; citation_author=H Baumann, J Gauldie; citation_volume=15; citation_publication_date=1994; citation_pages=74-80; citation_doi=10.1016/0167-5699(94)90137-6; citation_id=CR4
citation_journal_title=Am J Vet Res; citation_title=Serum amyloid A concentrations in cows given endotoxin as an acute phase stimulant; citation_author=R Boosman, TA Niewold, CWAA Mutsaers, E Gruys; citation_volume=50; citation_publication_date=1989; citation_pages=1690-1694; citation_id=CR5
citation_journal_title=Res Vet Sci; citation_title=Bovine acute phase response following turpentine injection; citation_author=JG Conner, PD Eckersall, A Wiseman, TC Aitchison, TA Douglas; citation_volume=44; citation_publication_date=1988; citation_pages=82-88; citation_id=CR6
citation_title=Occurrence of sialic acid; citation_inbook_title=Sialic acids; citation_publication_date=1982; citation_pages=5-50; citation_id=CR7; citation_author=AP Corfield; citation_author=R Schauer; citation_publisher=Springer-Verlag
citation_journal_title=Am J Physiol; citation_title=Evidence of brief stress may induce the acute phase response in rats; citation_author=T Deak, JL Meriwether, M Fleshner, RL Spencer, A Abouhamze, LL Moldawer, RE Grahn, LR Watkins, SF Maier; citation_volume=273; citation_publication_date=1997; citation_pages=1998-2004; citation_id=CR8
citation_journal_title=Res Vet Sci; citation_title=Serum haptoglobin: an objective indicator of experimentally induced Salmonella infection in calves; citation_author=T Deignan, A Alwan, J Kelly, J McNair, T Warren, C O’Farrelly; citation_volume=69; citation_publication_date=2000; citation_pages=153-158; citation_doi=10.1053/rvsc.2000.0403; citation_id=CR9
citation_journal_title=Vet J; citation_title=The time is right for acute phase protein assays; citation_author=PD Eckersall; citation_volume=168; citation_publication_date=2004; citation_pages=3-5; citation_id=CR10
citation_journal_title=Vet J; citation_title=The monitoring, prevention and treatment of sub-acute ruminal acidosis (SARA): a review; citation_author=JMD Enemark; citation_volume=176; citation_publication_date=2008; citation_pages=32-43; citation_doi=10.1016/j.tvjl.2007.12.021; citation_id=CR11
citation_journal_title=Vet Zootec; citation_title=Rumen acidosis with special emphasis of diagnostic aspects of subclinical rumen acidosis: a review; citation_author=JM Enemark, RJ Jørgensen, P Enemark; citation_volume=20; citation_publication_date=2002; citation_pages=16-29; citation_id=CR12
citation_title=Schalm’s Veterinary Hematology; citation_publication_date=2000; citation_id=CR13; citation_author=BV Feldman; citation_author=JG Zinkl; citation_author=NC Jain; citation_publisher=Williams & Wilkins
citation_journal_title=J Dairy Sci; citation_title=Ruminal lipopolysaccharide concentration and inflammatory response during gradual stepwise adaptation to concentrate and subsequent induction of subacute ruminal acidosis in steers; citation_author=GN Gozho, JC Plazier, DO Krause; citation_volume=89; citation_publication_date=2006; citation_pages=4404-4413; citation_doi=10.3168/jds.S0022-0302(06)72487-0; citation_id=CR14
citation_journal_title=J Dairy Sci; citation_title=Sub acute ruminal acidosis induces ruminal lipopolysaccharide endotoxin release and triggers an inflammatory response; citation_author=GN Gozho, JC Plazier, DO Krause, AD Kennedy, KM Wittenberg; citation_volume=88; citation_publication_date=2005; citation_pages=1399-1403; citation_doi=10.3168/jds.S0022-0302(05)72807-1; citation_id=CR15
citation_journal_title=J Dairy Sci; citation_title=Ruminal lipopolysaccharide concentration and inflammatory response during grain-induced subacute ruminal acidosis in dairy cows; citation_author=GN Gozho, DO Krause, JC Plazier; citation_volume=90; citation_publication_date=2007; citation_pages=856-866; citation_doi=10.3168/jds.S0022-0302(07)71569-2; citation_id=CR16
citation_journal_title=Vet Bull; citation_title=Diagnostic significance of the major acute phase proteins in veterinary clinical chemistry: a review; citation_author=E Gruys, MJ Obwalo, MJM Toussaint; citation_volume=64; citation_publication_date=1994; citation_pages=1009-1018; citation_id=CR17
citation_journal_title=J Zhejiang Univ SCI B; citation_title=Acute phase reaction and acute phase proteins; citation_author=E Gruys, MJM Toussaint, TA Neiwold, SJ Koopmans; citation_volume=6; citation_publication_date=2005; citation_pages=1045-1056; citation_doi=10.1631/jzus.2005.B1045; citation_id=CR18
citation_journal_title=Ann Clin Biochem; citation_title=Serum total sialic acid and lipid-associated sialic acid in normal individual patients with myocardial infarction and their relationship to acute phase proteins; citation_author=M Haq, S Haq, P Tutt, M Crook; citation_volume=30; citation_publication_date=1993; citation_pages=383-386; citation_id=CR19
citation_journal_title=Vet Immunol Immunopathol; citation_title=The acute phase response of haptoglobin and serum amyloid A (SAA) in cattle undergoing experimental infection with bovine respiratory syncitial virus; citation_author=PMH Heegaard, DL Godson, MJM Toussaint, K Tjørnehøj, LE Larsen, B Viuff, L Rønsholt; citation_volume=77; citation_publication_date=2000; citation_pages=151-159; citation_doi=10.1016/S0165-2427(00)00226-9; citation_id=CR20
citation_journal_title=J Anim Sci; citation_title=The effect of abrupt weaning of suckler calves on the plasma concentration of cortisol, catecholamines, leukocytes, acute-phase proteins and in vitro interferon-gamma production; citation_author=MC Hickey, M Drennan, B Early; citation_volume=81; citation_publication_date=2003; citation_pages=2847-2855; citation_id=CR21
citation_journal_title=J Anim Sci; citation_title=Behavioral, endocrine, immune and performance measures for pigs exposed to acute stress; citation_author=TA Hicks, JJ Mcglone, CS Whisnant, HG Kattesh, RL Norman; citation_volume=76; citation_publication_date=1998; citation_pages=474-483; citation_id=CR22
citation_journal_title=Revue Med Vet; citation_title=Detection of serum total sialic acid in cattle with natural tropical theileriosis; citation_author=T Ilhan Karagenc, F Kargin Kiral, K Seyrek, A Bildik, H Eren; citation_volume=156; citation_publication_date=2005; citation_pages=578-582; citation_id=CR23
citation_journal_title=J Dairy Sci; citation_title=Dose dependency and individual variability of the lipopolysaccharide-induced bovine acute phase protein response; citation_author=S Jacobsen, PH Andersen, T Toelboell, PMH Heegaard; citation_volume=87; citation_publication_date=2004; citation_pages=3330-3339; citation_doi=10.3168/jds.S0022-0302(04)73469-4; citation_id=CR24
citation_journal_title=Cancer Res; citation_title=Lipid-associated sialic acid test for the detection of human cancer; citation_author=N Katopodis, Y Hirshaut, NL Geller, CC Stock; citation_volume=42; citation_publication_date=1982; citation_pages=5270-5275; citation_id=CR25
citation_journal_title=Int Rev Cytol; citation_title=Sialic acid in molecular and cellular interactions; citation_author=S Kelm, R Schauer; citation_volume=175; citation_publication_date=1997; citation_pages=137-240; citation_doi=10.1016/S0074-7696(08)62127-0; citation_id=CR26
citation_journal_title=J Vet Med A; citation_title=Sub acute ruminal acidosis (SARA): a review; citation_author=JL Kleen, GA Hooijer, J Rehage, JP Noordhuizen; citation_volume=50; citation_publication_date=2003; citation_pages=406-414; citation_doi=10.1046/j.1439-0442.2003.00569.x; citation_id=CR27
citation_journal_title=Clin Rheumatol; citation_title=The acute phase response: general aspects. Bailtieres; citation_author=I Kushner, DL Rzewincki; citation_volume=8; citation_publication_date=1994; citation_pages=513-530; citation_id=CR28
citation_journal_title=Vet Res Commun; citation_title=Acute phase protein in cattle after exposure to complex stress; citation_author=SR Lomborg, LR Nielsen, PMH Heegaard, S Jacobsen; citation_volume=32; citation_publication_date=2008; citation_pages=575-582; citation_doi=10.1007/s11259-008-9057-7; citation_id=CR29
citation_journal_title=Biochimie; citation_title=N-Glycolylneuraminic acid in human tumors; citation_author=YN Malykhy, R Schauer, L Shaw; citation_volume=83; citation_publication_date=2001; citation_pages=623-634; citation_doi=10.1016/S0300-9084(01)01303-7; citation_id=CR30
citation_journal_title=Vet Immunol Immunopathol; citation_title=Stress alters the cellular and proteomic compartments in bovine bronchoalveolar lavage fluid; citation_author=GB Mitchell, ME Clark, M Siwicky, JL Caswell; citation_volume=125; citation_publication_date=2008; citation_pages=111-125; citation_doi=10.1016/j.vetimm.2008.05.005; citation_id=CR31
citation_journal_title=J Biol Chem; citation_title=The role of glycoproteins in the circulation; citation_author=AG Morell, G Gregoriadis, IH Scheinberg, J Hickman, G Ashwell; citation_volume=246; citation_publication_date=1971; citation_pages=1461-1467; citation_id=CR32
citation_journal_title=Nat Inst Anim Heal; citation_title=Determination and clinical evaluation of sialic acid and mucoprotein in bovine blood; citation_author=Y Motoi; citation_volume=37; citation_publication_date=1984; citation_pages=643-649; citation_id=CR33
citation_journal_title=Vet J; citation_title=Stress and acute phase protein response: an inconspicuous but essential linkage; citation_author=H Mutara; citation_volume=173; citation_publication_date=2007; citation_pages=473-474; citation_doi=10.1016/j.tvjl.2006.05.008; citation_id=CR34
citation_journal_title=Vet J; citation_title=Current research on acute phase proteins in veterinary diagnosis: an overview; citation_author=H Mutara, N Shimada, M Yoshioka; citation_volume=168; citation_publication_date=2004; citation_pages=28-40; citation_doi=10.1016/S1090-0233(03)00119-9; citation_id=CR35
citation_journal_title=J Anim Sci; citation_title=Relationship of rumen gram-negative bacteria and free endotoxin to lactic acidosis in cattle; citation_author=TG Nagaraja, EE Bartley, LR Fina, HD Anthony; citation_volume=47; citation_publication_date=1978; citation_pages=1329-1336; citation_id=CR36
citation_journal_title=Vet J; citation_title=Characterization of the pig acute phase protein response to road transport; citation_author=M Pineiro, C Pinerio, R Carpontero, J Morales, FM Campbell, PD Eckersall, MJ Taussaint, F Lampreave; citation_volume=173; citation_publication_date=2007; citation_pages=669-674; citation_doi=10.1016/j.tvjl.2006.02.006; citation_id=CR37
citation_title=Circulating sialyl compounds; citation_inbook_title=Biological roles of sialic acid; citation_publication_date=1976; citation_pages=275-294; citation_id=CR38; citation_author=A Rosenberg; citation_author=CL Schengrund; citation_publisher=Plenum Publishing Corp
citation_journal_title=Tumor Biol; citation_title=The utility of lipid-associated sialic acid (LASA or LSA) as serum marker for malignancy. A review of literature; citation_author=EM Schutter, JJ Visser, GJ Kamp, S Mensdorff-Pouilly, M Dick, J Higers, P Kenemans; citation_volume=13; citation_publication_date=1992; citation_pages=121-132; citation_doi=10.1159/000217755; citation_id=CR39
citation_journal_title=Bull Vet Inst Pulawy; citation_title=Serum sialic acid, malondialdehyde, retinol, zinc, and copper concentrations in dairy cows with lameness; citation_author=K Seyrek, E Yaylak, H Akşit; citation_volume=52; citation_publication_date=2008; citation_pages=281-284; citation_id=CR40
citation_journal_title=Clin Chem; citation_title=Measurement of human serum ceruloplasmin by its ρ-phenylene diamine oxidase activity; citation_author=FW Sunderman, S Nomoto; citation_volume=16; citation_publication_date=1970; citation_pages=903-910; citation_id=CR41
citation_journal_title=Kobe J Med Sci; citation_title=A new enzymatic method for the determination of sialic acid in serum and its application for a marker of acute phase reactants; citation_author=K Taniuchi, K Chifu, N Hayashi, Y Nakamachi, N Yamaguchi, Y Miyamoto, K Doi, S Baba, Y Uchida, Y Tsukada, T Sugimori; citation_volume=27; citation_publication_date=1981; citation_pages=91-102; citation_id=CR42
citation_title=Veterinary hematology and clinical chemistry; citation_publication_date=2004; citation_id=CR43; citation_author=MA Thrall; citation_publisher=Lippincott Williams and Wilkins
citation_journal_title=Res Vet Sci; citation_title=Characterization of the acute phase response of heifers to a prolonged low dose infusion of lipopolysaccharide; citation_author=D Werling, F Sutter, M Arnold, G Kun, PCJ Tooten, E Gruys, M Kruezer, W Langhans; citation_volume=61; citation_publication_date=1996; citation_pages=252-257; citation_doi=10.1016/S0034-5288(96)90073-9; citation_id=CR44
citation_journal_title=Clin Chim Acta; citation_title=Clinical significance of serum total sialic acid in cholangiocarcinoma; citation_author=S Wongkham, V Bhudhisawasdi, S Chau-In, C Boonla, K Muisuk, S Kongkham, C Wongkham, P Boonsiri, P Thauwajit; citation_volume=327; citation_publication_date=2003; citation_pages=139-147; citation_doi=10.1016/S0009-8981(02)00371-6; citation_id=CR45