Changes in Progesterone Metabolites in the Hippocampus Can Modulate Open Field and Forced Swim Test Behavior of Proestrous Rats

Akwa, 1999, The amygdala mediates the anxiolytic-like effect of the neurosteroid allopregnanolone in rat, Behav. Brain Res., 106, 119, 10.1016/S0166-4328(99)00101-1

Alonso, 1991, Sex differences in behavioral despair: Relationships between behavioral despair and open field activity, Physiol. Behav., 49, 6972, 10.1016/0031-9384(91)90232-D

Anderson, 1940, The sex hormones and emotional behavior: 1. The effect of sexual receptivity upon timidity in the female rat, J. Gen. Psych., 56, 149

Archer, 1975, Rodent sex differences in emotional and related behaviors, Behav. Biol., 14, 451, 10.1016/S0091-6773(75)90636-7

Bernardi, 1989, Influence of ovariectomy, estradiol and progesterone on the behavior of mice in an experimental model of depression, Physiol. Behav., 46, 1067, 10.1016/0031-9384(89)90238-2

Bitran, 1999, Anxiolytic effects of the neuroactive steroid pregnanolone (3α-OH-5β-pregnan-20-one) after microinjection in the dorsal hippocampus and lateral septum, Brain Res., 850, 217, 10.1016/S0006-8993(99)02150-2

Bitran, 2000, Activation of peripheral benzodiazepine receptors in the hippocampus stimulates allopregnanolone synthesis and produces anxiolytic effects, Psychopharm., 151, 64, 10.1007/s002130000471

Bitran, 1991, Anxiolytic effects of 3α-hydroxy-5α<β>-pregnan-20-one-endogenous metabolites of progesterone that are active at the GABAA receptor, Brain Res., 561, 157, 10.1016/0006-8993(91)90761-J

Bitran, 1991, Ovarian endocrine status modulates the anxiolytic potency of diazepam and the efficacy of GABA-benzodiazepine receptor-mediated chloride ion transport, Behav. Neurosci., 105, 653, 10.1037/0735-7044.105.5.653

Bitran, 1995, Anxiolytic effect of progesterone is mediated by the neurosteroid allopregnanolone at brain GABAA receptors, J. Neuroendocrinol., 7, 171, 10.1111/j.1365-2826.1995.tb00744.x

Blizard, 1975, Sex differences in open-field behavior in the rat: The inductive and activational role of gonadal hormones, Physiol. Behav., 14, 601, 10.1016/0031-9384(75)90188-2

Brot, 1997, The anxiolytic-like effects of the neurosteroid allopregnanolone: Interactions with GABAA receptors, Eur. J. Pharmacol., 325, 1, 10.1016/S0014-2999(97)00096-4

Calhoun, J. B. 1963, The Ecology and Sociology of the Norway Rat, U.S. Department of Health, Education, and Welfare, Washington, DC.

Carboni, 1996, Anxiolytic properties of endogenously occurring pregnanediols in two rodent models of anxiety, Psychopharmacol., 126, 173, 10.1007/BF02246353

Contreras, 1998, Desipramine restricts estral cycle oscillations in swimming, Prog. Neuropsychopharmacol. Biol. Psychiatry, 22, 1121, 10.1016/S0278-5846(98)00066-9

Critchlow, 1963, Sex differences in resting pituitary-adrenal function in the rat, Am. J. Physiol., 205, 807, 10.1152/ajplegacy.1963.205.5.807

Fernandez-Guasti, 1999, Chronic treatment with desipramine induces an estrous cycle-dependent anxiolytic-like action in the burying behavior, but not in the elevated plus-maze test, Pharmacol. Biochem. Behav., 63, 13, 10.1016/S0091-3057(98)00231-7

Fernandez-Guasti, 1990, The actions of diazepam and serotonergic anxiolytics vary according to the gender and the estrous cycle phase, Pharmacol. Biochem. Behav., 37, 77, 10.1016/0091-3057(90)90044-I

Fernandez-Guasti, 1992, Changes in burying behavior during the estrous cycle—Effect of estrogen and progesterone, Psychoneuroendocrinol., 17, 681, 10.1016/0306-4530(92)90027-5

Fernandez-Guasti, 1999, Sexual differentiation modifies the allopregnanolone anxiolytic actions in rats, Psychoneuroendocrinol., 24, 251, 10.1016/S0306-4530(98)00048-1

Finn, 1994, The estrous cycle, sensitivity to convulsants and the anticonvulsant effect of a neuroactive steroid, J. Pharmacol. Exp. Ther., 271, 164

Frye, 1999, Mating stimuli influence endogenous variations in the neurosteroids 3α,5α-THP and 3α-Diol, J. Neuroendocrinol., 11, 839, 10.1046/j.1365-2826.1999.00379.x

Frye, 1998, The neurosteroids, progesterone and 3α,5α-THP, enhance sexual motivation, receptivity, and proceptivity in female rats, Brain Res., 808, 72, 10.1016/S0006-8993(98)00764-1

Frye, 1992, Hormonal milieu affects tailflick latency in female rats and may be attenuated by access to sucrose, Physiol. Behav., 52, 699, 10.1016/0031-9384(92)90400-V

Frye, 1994, Progesterone metabolites, effective at the GABAA receptor complex, attenuate pain sensitivity in rats, Brain Res., 643, 194, 10.1016/0006-8993(94)90025-6

Frye, 1995, Estradiol benzoate potentiates neuroactive steroids' effects on pain sensitivity, Pharmacol. Biochem. Behav., 53, 27, 10.1016/0091-3057(95)00194-8

Frye, 2000, Estrous cycle and sex differences in performance on anxiety tasks coincide with increases in hippocampal progesterone and 3α,5α-THP, Pharmacol. Biochem. Behav., 67, 587, 10.1016/S0091-3057(00)00392-0

Gallo, 1993, Progesterone withdrawal decreases latency to and increases duration of electrified prod burial: A possible rat model of PMS anxiety, Pharmacol. Biochem. Behav., 46, 897, 10.1016/0091-3057(93)90219-J

Ganesan, 1994, The aversive and hypophagic effects of estradiol, Physiol. Behav., 55, 279, 10.1016/0031-9384(94)90134-1

Gould, 1990, Gonadal steroids regulate dendritic spine density in hippocampal pyramidal cells in adulthood, J. Neurosci., 10, 1286, 10.1523/JNEUROSCI.10-04-01286.1990

Gray, 1964, Effects of induced oestrus on emotional behavior in selected strains of rats, Nature, 201, 1198, 10.1038/2011198a0

Johnston, 1991, Sex differences in animal tests of anxiety, Physiol. Behav., 49, 245, 10.1016/0031-9384(91)90039-Q

Kanarek, 1980, Role of gonadal hormones in diet selection and food utilization in female rats, Physiol. Behav., 24, 381, 10.1016/0031-9384(80)90102-X

Kawakami, 1970, Changes in multiple unit activity in the brain during the estrous cycle, Neuroendocrinol., 6, 30, 10.1159/000121900

Kellogg, 1999, Reduced progesterone metabolites are not critical for plus-maze performance of lactating female rats, Pharmacol. Biochem. Behav., 63, 441, 10.1016/S0091-3057(99)00041-6

Khisti, 2000, Serotonergic agents modulate antidepressant-like effect of the neurosteroid 3α-hydroxy-5α-pregnan-20-one in mice, Brain Res., 865, 291, 10.1016/S0006-8993(00)02373-8

Khisti, 2000, Antidepressant-like effect of the neurosteroid 3α-hydroxy-5α-pregnan-20-one in mice forced swim test, Pharmacol. Biochem. Behav., 67, 137, 10.1016/S0091-3057(00)00300-2

Korol, 1994, Estrogen effects on spatial performance and hippocampal physiology in female rats, Soc. Neurosci. Abstr., 20

Martinez-Mota, L., Contreras, C. M., and Saavedra, M.Progesterone reduces immobility in rats forced to swim. Arch. Med. Res.30, 286–289.

Martinez-Mota, 2000, Interaction of desipramine with steroid hormones on experimental anxiety, Psychoneuroendocrinol., 25, 109, 10.1016/S0306-4530(99)00042-6

Marvan, 1996, Clomipramine modifies fluctuations of forced swimming immobility in different phases of the rat estrous cycle, Arch. Med. Res., 27, 83

Marvan, 1997, Inescapable shocks accentuate fluctuations of forced swimming immobility in different phases of the rat estrous cycle, Arch. Med. Res., 28, 369

McCarthy, 1995, Infusions of diazepam and allopregnanolone into the midbrain central gray facilitate open-field behavior and sexual receptivity in female rats, Horm. Behav., 29, 279, 10.1006/hbeh.1995.1020

Mora, 1996, Effects of the estrous cycle and ovarian hormones on behavioral indices of anxiety in female rats, Psychoneuroendocrinol., 21, 609, 10.1016/S0306-4530(96)00015-7

Okada, 1997, Influences of ovariectomy and continuous replacement of 17β-estradiol on the tail skin temperature and behavior in the forced swimming test in rats, Jpn. J. Pharmacol., 73, 93, 10.1254/jjp.73.93

Pare, 1993, Sex differences and stress response of WKY rats, Physiol. Behav., 54, 1179, 10.1016/0031-9384(93)90345-G

Paxinos, 1986

Porsolt, 1977, Depression: A new model sensitive to antidepressant treatments, Nature., 266, 730, 10.1038/266730a0

Purdy, 1990, Radioimmunoassay of 3α-hydroxy-5α-pregnan-20-one in rat and human plasma, Steroids., 55, 290, 10.1016/0039-128X(90)90031-6

Rachman, 1998, Estrogen alters behavior and forebrain c-fos expression in ovariectomized rats subjected to the forced swim test, Proc. Natl. Acad. Sci., 95, 13,941, 10.1073/pnas.95.23.13941

Rhodes, 2001, Inhibiting progesterone metabolism in the hippocampus of proestrous rats decreases anxiolytic, and enhances, exploration and analgesia, Cog. Affect. Behav. Neurosci., 1, 287, 10.3758/CABN.1.3.287

Rodbard, D, and, Hutt, D. M. 1974, Statistical analysis of radioimmunoassay and immunoradiometric assays: A generalized, weighted iterative, least squares method for logistic curve fitting, In, International Atomic Energy Agency, (Ed.), Symposium on Radioimmunoassay and Related Procedures in Medicine, Uniput, New York.

Rodriguez-Sierra, 1986, Anxiolytic effects of progesterone are sexually dimorphic, Life Sci., 38, 1841, 10.1016/0024-3205(86)90139-6

Rodriguez-Sierra, 1984, Effect of ovarian hormones on conflict behavior, Psychoneuroendocrinol., 9, 293, 10.1016/0306-4530(84)90008-8

Smythe, 1994, The interaction between prenatal stress and neonatal handling on nociceptive response latencies in male and female rats, Physiol. Behav., 55, 971, 10.1016/0031-9384(94)90089-2

Teresawa, 1968, Electrical activity during the estrous cycle of the rat: Cyclic changes in limbic structures, Endocrinol., 83, 207, 10.1210/endo-83-2-207

Viau, 1991, Variations in the hypothalamic-pituitary adrenal response to stress during the estrous cycle in the rat, Endocrinol., 129, 2503, 10.1210/endo-129-5-2503

Vinogradova, 1999, The effect of different stages of the sex cycle on rat behavior in a plus maze, Zh. Vyssh. Nerv. Deiat. Im. I. P. Pavlova, 49, 1039

Wade, 1976, Sex hormones, regulatory behaviors, and body weight, 10.1016/S0065-3454(08)60085-6

Wade, 1979, Gonadal effects on food intake and adiposity: A metabolic hypothesis, Physiol. Behav., 22, 583, 10.1016/0031-9384(79)90028-3

Walker, 1995, Dissociation between behavioral and hormonal responses to the forced swim stress in lactating rats, J. Neuroendocrinol., 7, 615, 10.1111/j.1365-2826.1995.tb00799.x

Warren, 1995, LTP varies across the estrous cycle: Enhanced synaptic plasticity in proestrous rats, Brain Res., 703, 26, 10.1016/0006-8993(95)01059-9

Zimmerberg, 1993, Sex differences in anxiety behavior in rats: Role of gonadal hormones, Physiol. Behav., 54, 1119, 10.1016/0031-9384(93)90335-D