Cerebrospinal Cytokine Levels in Patients with Acute Depression

Neuropsychobiology - Tập 40 Số 4 - Trang 171-176 - 1999
Jay F. Levine1,2, Yoram Barak3, K.N.R. Chengappa2, A. Rapoport4, M. Rebey5, Vivian Barak6
1Beersheva Mental Health Center, Faculty of Health Sciences, Ben Gurion University of the Negev, Beersheva, Israel
2Western Psychiatric Institute and Clinic, Pittsburgh PA, USA
3Abrabanel Mental Health Center Bat Yam, Israel
4Volfson Hospital, Neurology Department, Holon, Israel
5Assaf Harofe Hospital, Neurology Department, Beer Yaacov, Israel and
6Immunology Laboratory for Tumor Diagnosis, Oncology Department, Hadassah University Hospital, Jerusalem, Israel

Tóm tắt

There is increasing evidence for an association between the alteration of cytokine concentrations in blood and the pathophysiology of depressive disorders. Studies in humans have not investigated CSF cytokine concentrations and their relationship to depressive disorders. This study reports on the association of the CSF concentration of proinflammatory cytokines, IL-1β, IL-6 and TNFα, and major depressive disorders. CSF samples were obtained from 13 hospitalized patients with acute unmedicated severe depression and were compared with 10 control subjects. Compared to the control group, the depressed patient group had higher CSF concentrations of IL-1β, lower IL-6 and no change in TNFα. A positive correlation was found between serum IL-1β and the severity of depression. These results indicate a unique profile for CSF proinflammatory cytokines in acute depression. These findings merit further investigation and if replicated may possibly offer immunological treatment options for depression.

Từ khóa


Tài liệu tham khảo

10.1016/0361-9230(92)90148-Q

10.1016/0006-8993(93)90090-A

10.1073/pnas.93.9.3908

10.1016/S0024-3205(97)00990-9

10.1016/S0002-9343(97)00275-1

10.1016/S0006-3223(97)00401-0

Thông tin
Thông tin xuất bản

Neuropsychobiology

Tập 40 Số 4

171-176

Thông tin tác giả