Cerebral Microbleeds: Histopathological Correlation of Neuroimaging

Cerebrovascular Diseases - Tập 32 Số 6 - Trang 528-534 - 2011
Ashkan Shoamanesh1, Chun Shing Kwok2, Oscar Benavente3,1
1Division of Neurology, Department of Medicine, and
2School of Medicine, Health Policy and Practice, Health and Social Sciences Research Institute, Faculty of Health, University of East Anglia, Norwich, UK
3Brain Research Center, UBC Hospital, University of British Columbia, Vancouver, B.C., Canada

Tóm tắt

<i>Background:</i> In recent years, there has been a growing interest in cerebral microbleeds (CMBs) and their role in cerebrovascular disease. A few studies have investigated the histopathological correlation between CMBs and neuroimaging findings. We conducted a systematic review in an attempt to characterize the pathological and radiological correlation. <i>Methods:</i> A systematic literature search was conducted for studies in which CMBs were characterized histopathologically and correlated with MRI findings. <i>Results:</i> Five studies met the inclusion criteria, with a total of 18 patients. Hemosiderin deposition was reported in 42 CMBs (49%), while 16 CMBs (19%) were described as old hematomas which stained for iron, 13 (15%) had no associated specific pathology, 11 (13%) contained intact erythrocytes, 1 (1%) was due to vascular pseudocalcification, 1 (1%) was a microaneurysm and 1 (1%) was a distended dissected vessel. Lipofibrohyalinosis was the most prominent associated vascular finding. Amyloid angiopathy was present primarily in patients with dementia. <i>Conclusions:</i> Although histopathological associations have been observed using MRI in patients with CMBs, the findings have yet to be validated and further research is warranted.

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Cerebrovascular Diseases

Tập 32 Số 6

528-534

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