Cerebral Metabolic Relationships for Selected Brain Regions in Alzheimer's, Huntington's, and Parkinson's Diseases

Journal of Cerebral Blood Flow and Metabolism - Tập 4 Số 4 - Trang 500-506 - 1984
E. Jeffrey Metter1,2, Walter H. Riege1,2, M Kameyama1, David E. Kuhl1, Michael E. Phelps1
1* Laboratory of Nuclear Medicine, UCLA School of Medicine
2Veterans Administration Medical Center, Sepulveda, California, U.S.A.

Tóm tắt

Local CMRGlc values were determined for 13 regions in each hemisphere from tomographs of patients with Alzheimer's, Huntington's, and Parkinson's diseases who were studied using [18F]fluorodeoxyglucose with positron emission computed tomography. Intercorrelations among the 26 regional measures were calculated for each disease state and for normal controls, and were accepted as reliable at p < 0.01, uncorrected for the number of comparisons. The number of reliable correlations was found to be decreased in Parkinson's and Huntington's diseases, two primarily subcortical disorders, and increased in Alzheimer's disease, a primarily cortical disorder. The changes suggest that one role of the basal ganglia involves coordinating or pacing the ability of cortical brain regions to function as a unit.

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Tài liệu tham khảo

10.1001/archneur.1983.04050110029003

10.1038/jcbfm.1983.3

DeLeon M.J., 1983, AJNR, 5, 553

DeLeon M.J., 1983, AJNR, 4, 568

10.1016/B978-0-08-023174-7.50019-9

Fabre N., 1983, J Cerebr Blood Flow Metabol, 3, S516, 10.1038/jcbfm.1983.79

10.1176/ajp.139.3.352

10.1093/brain/104.4.753

Friedland R.P., 1983, J Cereb Blood Flow Metabol, 3, S510

Globus M., 1983, J Cereb Blood Flow Metabol, 3, S508, 10.1038/jcbfm.1983.43

10.1038/jcbfm.1983.34

Hays W.L., 1973, Statistics for the Social Sciences, 2

Herscovitch P., 1983, J Nucl Med, 24, P106

Huang S.C., 1980, Am J Physiol, 238, E69

10.1093/brain/93.3.525

10.1002/ana.410120504

Kuhl D.E., 1983, J Cereb Blood Flow Metabol, 3, S494

10.1002/ana.410150504

10.1001/archneur.1979.00500420054005

Leenders K., 1983, J Cereb Blood Flow Metabol, 3, S488

10.1136/jnnp.42.1.59

Matsui T., 1978, An Atlas of the Human Brain for Computerized Tomography

10.1212/WNL.32.9.921

Metter E.J., 1983, J Cereb Blood Flow Metabol, 3, S482

10.1038/jcbfm.1984.1

Phelps M.E., 1978, J Nucl Med, 19, 635

10.1002/ana.410060502

10.1212/WNL.31.5.517

Rougemont D., 1983, J Cereb Blood Flow Metabol, 3, S504

10.1016/0006-8993(78)90059-8

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Thông tin xuất bản

Journal of Cerebral Blood Flow and Metabolism

Tập 4 Số 4

500-506

Thông tin tác giả