Ceramide from sphingomyelin hydrolysis differentially mediates mitogen-activated protein kinases (MAPKs) activation following cerebral ischemia in rat hippocampal CA1 subregion

Chang, 2001, Mammalian MAP kinase signalling cascades, Nature, 410, 37, 10.1038/35065000 Pearson, 2001, Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions, Endocr Rev, 22, 153, 10.1210/er.22.2.153 Mehta, 2007, Molecular targets in cerebral ischemia for developing novel therapeutics, Brain Res Rev, 54, 34, 10.1016/j.brainresrev.2006.11.003 Xia, 1995, Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis, Science, 270, 1326, 10.1126/science.270.5240.1326 Seger, 1995, The MAPK signaling cascade, FASEB J, 9, 726, 10.1096/fasebj.9.9.7601337 Zhao, 2008, Protein phosphatase 2A-negative regulation of the protective signaling pathway of Ca2+/CaM-dependent ERK activation in cerebral ischemia, J Neurosci Res, 86, 2733, 10.1002/jnr.21712 Yu, 2000, Pivotal role for acidic sphingomyelinase in cerebral ischemia-induced ceramide and cytokine production, and neuronal apoptosis, J Mol Neurosci, 15, 85, 10.1385/JMN:15:2:85 Ohtani, 2004, Upregulation of ceramide and its regulating mechanism in a rat model of chronic cerebral ischemia, Brain Res, 1023, 31, 10.1016/j.brainres.2004.07.024 Andrieu-Abadie, 2002, Sphingomyelin hydrolysis during apoptosis, Biochim Biophys Acta, 1585, 126, 10.1016/S1388-1981(02)00332-3 Kolesnick, 1998, Regulation of ceramide production and apoptosis, Annu Rev Physiol, 60, 643, 10.1146/annurev.physiol.60.1.643 Ruvolo, 2003, Intracellular signal transduction pathways activated by ceramide and its metabolites, Pharmacol Res, 47, 383, 10.1016/S1043-6618(03)00050-1 Basu, 1998, Stress signals for apoptosis: ceramide and c-Jun kinase, Oncogene, 17, 3277, 10.1038/sj.onc.1202570 Hu, 2000, Alteration of MAP kinase pathways after transient forebrain ischemia, J Cereb Blood Flow Metab, 20, 1089, 10.1097/00004647-200007000-00008 Feng, 2006, N-tosyl-L-phenylalanyl-chloromethyl ketone reduces ceramide during hypoxic-ischemic brain injury in newborn rat, Eur J Pharmacol, 551, 34, 10.1016/j.ejphar.2006.08.070 Ferrer, 2003, Early modifications in the expression of mitogen-activated protein kinase (MAPK/ERK), stress-activated kinases SAPK/JNK and p38, and their phosphorylated substrates following focal cerebral ischemia, Acta Neuropathol, 105, 425, 10.1007/s00401-002-0661-2 Irving, 2002, Role of mitogen-and stress-activated kinases in ischemic injury, J Cereb Blood Flow Metab, 22, 631, 10.1097/00004647-200206000-00001 Xia, 1996, Calcium influx via the NMDA receptor induces immediate early gene transcription by a MAP kinase/ERK-dependent mechanism, J Neurosci, 16, 5425, 10.1523/JNEUROSCI.16-17-05425.1996 Wu, 2007, N-methyl-D-aspartate receptor mediate diphosphorylation of extracellular signal-regulated kinase through Src family tyrosine kinases and CaMKII following ischemia in rat hippocampus. Neurosci, Bull, 23, 78 Enslen, 1996, Regulation of mitogen-activated protein kinases by a calcium/calmodulin-dependent protein kinase cascade, Proc Natl Acad Sci U S A, 93, 10803, 10.1073/pnas.93.20.10803 Gu, 2000, Diphosphorylation of extracellular signal-regulated kinases and c-Jun N-terminal protein kinases in brain ischemic tolerance in rat, Brain Res, 860, 157, 10.1016/S0006-8993(00)02006-0 Guo, 2006, Sustained activation of Src-family tyrosine kinases by ischemia: a potential mechanism mediating extracellular signal-regulated kinase cascades in hippocampal dentate gyrus, Neuroscience, 143, 827, 10.1016/j.neuroscience.2006.08.031 Verheij, 1996, Requirement for ceramide-initiated SAPK/ JNK signaling in stress-induced apoptosis, Nature, 380, 75, 10.1038/380075a0 Brenner, 1997, Fas-or ceramide-induced apoptosis is mediated by a Rac1-regulated activation of Jun N-terminal kinase/p38 kinases and GADD153, J Biol Chem, 272, 22173, 10.1074/jbc.272.35.22173 Shirakabe, 1997, TAK1 mediates the ceramide signaling to stress-activated protein kinase/c-Jun N-terminal kinase, J Biol Chem, 272, 8141, 10.1074/jbc.272.13.8141 Bourbon, 2000, Ceramide directly activates protein kinase C zeta to regulate a stress-activated protein kinase signaling complex, J Biol Chem, 275, 35617, 10.1074/jbc.M007346200 Chen, 1999, ASK1 mediates apoptotic cell death induced by genotoxic stress, Oncogene, 18, 173, 10.1038/sj.onc.1202276 Takekawa, 1997, A human homolog of the yeast Ssk2/Ssk22 MAP kinase kinase kinases, MTK1, mediates stress-induced activation of the p38 and JNK pathways, EMBO J, 16, 4973, 10.1093/emboj/16.16.4973 Ho, 2007, Different mechanisms account for extracellular-signal regulated kinase activation in distinct brain regions following global ischemia and reperfusion, Neuroscience, 145, 248, 10.1016/j.neuroscience.2006.11.039 Prinetti, 1997, Involvement of a ceramide activated protein phosphatase in the differentiation of neuroblastoma Neuro2a cells, FEBS Lett, 414, 475, 10.1016/S0014-5793(97)00981-2 Denouel-Galy, 1998, Murine Ksr interacts with MEK and inhibits Ras-induced transformation, Curr Biol, 8, 46, 10.1016/S0960-9822(98)70019-3 Shen, 2003, Cross-talk between JNK/SAPK and ERK/MAPK pathways: sustained activation of JNK blocks ERK activation by mitogenic factors, J Biol Chem, 278, 26715, 10.1074/jbc.M303264200