Centralized Pan-Middle East Survey on the Undertreatment of Hypercholesterolemia

Angiology - Tập 65 Số 10 - Trang 919-926 - 2014
Mohamed Arafah1, Ali T. Al‐Hinai2, Wael Al Mahmeed3, Khalid Al‐Rasadi4, Omar Tamimi5, Shorook Al Herz6, Faisal Al Anazi7, Khalid Al Nemer8, Othman Metwally9, Akram Al-Khadra10, Mohammed Fakhry10, Hossam Elghetany11, Abdel Razak Medani12, Afzalhussein Yusufali12, Obaid Al Jassim12, Omar Al Hallaq13, Fahad Baslaib14, Mahmoud Alawadhi15, Haitham Amin16, Khamis Al-Hashmi2, Abdullah Shehab17
1King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia
2Sultan Qaboos University, College of Medicine & Health Sciences, Muscat, Oman
3Sheikh Khalifa Medical City, Abu Dhabi, United Arab Emirates
4Sultan Qaboos University Hospital, Muscat, Oman
5Hamad Medical Corporation, Doha, Qatar
6King Fahad National Guard Hospital, Riyadh, Kingdom of Saudi Arabia
7Ministry of Health, Riyadh, Kingdom of Saudi Arabia
8Security Force Hospital, Riyadh, Kingdom of Saudi Arabia
9King Fahad General Hospital, Jeddah, Kingdom of Saudi Arabia
10King Fahad Hospital of the University, Khobar, Kingdom of Saudi Arabia
11Soliman Fakieh Hospital, Jeddah, Kingdom of Saudi Arabia
12Dubai Hospital, Dubai, United Arab Emirates
13American Hospital Dubai, United Arab Emirates
14Rashid Hospital, Dubai, United Arab Emirates
15Al Amiri Hospital, Kuwait City, Kuwait
16Bahrain Defence Force Hospital, Riffa, Bahrain
17UAE University, AlAin, United Arab Emirates

Tóm tắt

The Centralized pan-Middle East Survey on the undertreatment of hypercholesterolemia (CEPHEUS) survey evaluated the attainment of low-density lipoprotein cholesterol (LDL-C) goals among patients on lipid-lowering drugs (LLDs) according to the updated National Cholesterol Education Program (NCEP)-Adult Treatment Panel (ATP-III) guideline. The survey was conducted in 6 Arabian Gulf countries. Patients aged ≥18 years on LLDs for at least ≥3 months (stable medication for ≥6 weeks) were recruited. Fasting blood samples were collected at a single visit. In this survey, 5276 (58.2% male) patients were included in the final analysis. The LDL-C goal was attained in 91.1% of low-risk, 52.7% of high-risk, and 32.0% in very-high-risk categories. Goal attainment was directly related to female gender, age <40 years, history of diabetes, and family history of cardiovascular disease. The results of this survey highlight the suboptimal management of hypercholesterolemia across Arabian Gulf countries.

Từ khóa


Tài liệu tham khảo

Husseini A, 2009, Lancet, 373, 1764, 10.1016/S0140-6736(09)60983-1

Gehani Abdurrazzak A, 2012, Eur J Preventive Cardiol

10.1136/bmj.326.7404.1423

10.1016/S0195-668X(03)00347-6

10.1161/circ.106.25.3143

10.1161/01.CIR.0000133317.49796.0E

10.1093/oxfordjournals.eurheartj.a015136

10.1053/euhj.2001.2610

10.1161/01.CIR.0000066320.27195.B4

10.1001/archinte.160.4.459

10.1016/S0002-9343(02)01303-7

10.1093/eurheartj/ehm316

Alberti KG, 2009, Circulation, 120, 1640, 10.1161/CIRCULATIONAHA.109.192644

10.1016/j.ahj.2010.08.041

10.1093/eurheartj/ehl391

10.1097/01.hjr.0000277983.23934.c9

10.1001/archinte.167.8.847

10.1093/oxfordjournals.eurheartj.a015165

10.1592/phco.2005.25.8.1035

10.1001/jama.297.2.177

10.1093/oxfordjournals.eurheartj.a014826

10.1056/NEJM199511163332001

10.1056/NEJM199610033351401

The Scandinavian Simvastatin Survival Study Group, 1994, Lancet, 344, 1383

10.1001/jama.279.20.1615

Simes RJ, Program and abstracts of the 47th Annual Scientific Session of the American College of Cardiology, 1116, 1998

10.1056/NEJMoa0807646

10.1185/03007990903500565

10.1016/j.ijcard.2009.02.001

10.1185/03007990903512396

10.1177/1741826710397100

10.1177/0003319710366432

10.5830/CVJA-2011-044

10.1161/CIRCULATIONAHA.108.838466