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Vật liệu đóng gói chiral dạng hạt lai từ cellulose phenylcarbamate cho nhận diện chiral hiệu quả
Tóm tắt
Để phân tách enantiomer một cách hiệu quả, tám vật liệu đóng gói chiral dạng hạt lai hữu cơ-vô cơ (CPMs) với hàm lượng hữu cơ cao đã được phát triển bằng cách sử dụng cellulose tris(3,5-dimethylphenylcarbamates) mang một lượng nhỏ nhóm 3-(triethoxysilyl)propyl và tetraethyl orthosilicate thông qua quá trình Stöber đã được điều chỉnh trong điều kiện kiềm. Các hạt lai có thể được hình thành một cách hiệu quả hơn trong điều kiện kiềm mà không cần sử dụng chất hoạt động bề mặt, so với điều kiện axit. Các điều kiện chuẩn bị, bao gồm loại và số lượng chất xúc tác, lượng nước và nhiệt độ, đã tác động mạnh mẽ đến hàm lượng hữu cơ và hình thái của các CPM lai. Các đặc tính nhận diện chiral của chúng sau đó đã được khảo sát bằng phương pháp sắc ký lỏng hiệu năng cao. Các CPM lai thu được với hàm lượng hữu cơ cao hơn có khả năng phân tách enantiomer tốt hơn so với các CPM truyền thống và các mẫu tương tự trước đây được tạo ra từ điều kiện axit. Đối với một số racemate, các CPM lai thậm chí còn thể hiện tính chọn lọc enantiomer cao hơn cả Chiralpak IB N thương mại, đây là một trong những CPM kiểu cố định mạnh nhất và được chế tạo từ cellulose tris(3,5-dimethylphenylcarbamate).
Từ khóa
#Vật liệu đóng gói chiral #phân tách enantiomer #cellulose phenylcarbamate #sắc ký lỏng hiệu năng cao #vật liệu lai hữu cơ-vô cơTài liệu tham khảo
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