Cellular and molecular players in adipose tissue inflammation in the development of obesity-induced insulin resistance

Kahn, 2006, Mechanisms linking obesity to insulin resistance and type 2 diabetes, Nature, 444, 840, 10.1038/nature05482

Biddinger, 2006, From mice to men: insights into the insulin resistance syndromes, Annu. Rev. Physiol., 68, 123, 10.1146/annurev.physiol.68.040104.124723

White, 2003, Insulin signaling in health and disease, Science, 302, 1710, 10.1126/science.1092952

Pilch, 2004, Insulin receptor family, vol. 2, 436

Osborn, 2012, The cellular and signaling networks linking the immune system and metabolism in disease, Nat. Med., 18, 363, 10.1038/nm.2627

Choy, 2001, Cytokine pathways and joint inflammation in rheumatoid arthritis, N. Engl. J. Med., 344, 907, 10.1056/NEJM200103223441207

Hansson, 2005, Inflammation, atherosclerosis, and coronary artery disease, N. Engl. J. Med., 352, 1685, 10.1056/NEJMra043430

De Caterina, 2004, From asthma to atherosclerosis–5-lipoxygenase, leukotrienes, and inflammation, N. Engl. J. Med., 350, 4, 10.1056/NEJMp038190

Lee, 2013, Adipose tissue macrophages in the development of obesity-induced inflammation, insulin resistance and Type 2 Diabetes, Arch. Pharmacal Res., 36, 208, 10.1007/s12272-013-0023-8

Libby, 2011, Progress and challenges in translating the biology of atherosclerosis, Nature, 473, 317, 10.1038/nature10146

Stephens, 1992, Transcriptional repression of the C/EBP-alpha and GLUT4 genes in 3 T3-L1 adipocytes by tumor necrosis factor-alpha. Regulations is coordinate and independent of protein synthesis, J. Biol. Chem., 267, 13580, 10.1016/S0021-9258(18)42251-X

Stephens, 1997, Tumor necrosis factor-alpha-induced insulin resistance in 3 T3-L1 adipocytes is accompanied by a loss of insulin receptor substrate-1 and GLUT4 expression without a loss of insulin receptor-mediated signal transduction, J. Biol. Chem., 272, 971, 10.1074/jbc.272.2.971

Cheung, 1998, An in vivo model for elucidation of the mechanism of tumor necrosis factor-alpha (TNF-alpha)-induced insulin resistance: evidence for differential regulation of insulin signaling by TNF-alpha, Endocrinology, 139, 4928, 10.1210/endo.139.12.6336

Hotamisligil, 1993, Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance, Science, 259, 87, 10.1126/science.7678183

Uysal, 1997, Protection from obesity-induced insulin resistance in mice lacking TNF-alpha function, Nature, 389, 610, 10.1038/39335

Ventre, 1997, Targeted disruption of the tumor necrosis factor-alpha gene: metabolic consequences in obese and nonobese mice, Diabetes, 46, 1526, 10.2337/diab.46.9.1526

De Taeye, 2007, Macrophage TNF-alpha contributes to insulin resistance and hepatic steatosis in diet-induced obesity, Am. J. Physiol. Endocrinol. Metab., 293, E713, 10.1152/ajpendo.00194.2007

Festa, 2000, Chronic subclinical inflammation as part of the insulin resistance syndrome: the Insulin Resistance Atherosclerosis Study (IRAS), Circulation, 102, 42, 10.1161/01.CIR.102.1.42

Yudkin, 2000, Inflammation, obesity, stress and coronary heart disease: is interleukin-6 the link?, Atherosclerosis, 148, 209, 10.1016/S0021-9150(99)00463-3

Barzilay, 2001, The relation of markers of inflammation to the development of glucose disorders in the elderly: the Cardiovascular Health Study, Diabetes, 50, 2384, 10.2337/diabetes.50.10.2384

Ford, 2002, Leukocyte count, erythrocyte sedimentation rate, and diabetes incidence in a national sample of US adults, Am. J. Epidemiol., 155, 57, 10.1093/aje/155.1.57

Freeman, 2002, C-reactive protein is an independent predictor of risk for the development of diabetes in the West of Scotland Coronary Prevention Study, Diabetes, 51, 1596, 10.2337/diabetes.51.5.1596

Pickup, 2004, Inflammation and activated innate immunity in the pathogenesis of type 2 diabetes, Diabetes Care, 27, 813, 10.2337/diacare.27.3.813

Pradhan, 2003, C-reactive protein is independently associated with fasting insulin in nondiabetic women, Arterioscler. Thromb. Vasc. Biol., 23, 650, 10.1161/01.ATV.0000065636.15310.9C

Pradhan, 2001, C-reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus, JAMA, 286, 327, 10.1001/jama.286.3.327

Schmidt, 1999, Markers of inflammation and prediction of diabetes mellitus in adults (Atherosclerosis Risk in Communities study): a cohort study, Lancet, 353, 1649, 10.1016/S0140-6736(99)01046-6

Vozarova, 2002, High white blood cell count is associated with a worsening of insulin sensitivity and predicts the development of type 2 diabetes, Diabetes, 51, 455, 10.2337/diabetes.51.2.455

Barzilay, 2003, Inflammation and its association with glucose disorders and cardiovascular disease, Treat. Endocrinol., 2, 85, 10.2165/00024677-200302020-00002

Duncan, 2003, Low-grade systemic inflammation and the development of type 2 diabetes: the atherosclerosis risk in communities study, Diabetes, 52, 1799, 10.2337/diabetes.52.7.1799

Kim, 2001, Prevention of fat-induced insulin resistance by salicylate, J. Clin. Invest., 108, 437, 10.1172/JCI11559

Yuan, 2001, Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta, Science, 293, 1673, 10.1126/science.1061620

Fleischman, 2008, Salsalate improves glycemia and inflammatory parameters in obese young adults, Diabetes Care, 31, 289, 10.2337/dc07-1338

Goldfine, 2010, The effects of salsalate on glycemic control in patients with type 2 diabetes: a randomized trial, Ann. Intern. Med., 152, 346, 10.7326/0003-4819-152-6-201003160-00004

Goldfine, 2008, Use of salsalate to target inflammation in the treatment of insulin resistance and type 2 diabetes, Clin. Transl. Sci., 1, 36, 10.1111/j.1752-8062.2008.00026.x

Hundal, 2002, Mechanism by which high-dose aspirin improves glucose metabolism in type 2 diabetes, J. Clin. Invest., 109, 1321, 10.1172/JCI0214955

Lumeng, 2011, Inflammatory links between obesity and metabolic disease, J. Clin. Invest., 121, 2111, 10.1172/JCI57132

Gregor, 2011, Inflammatory mechanisms in obesity, Annu. Rev. Immunol., 29, 415, 10.1146/annurev-immunol-031210-101322

Xu, 2003, Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance, J. Clin. Invest., 112, 1821, 10.1172/JCI200319451

Weisberg, 2003, Obesity is associated with macrophage accumulation in adipose tissue, J. Clin. Invest., 112, 1796, 10.1172/JCI200319246

Ferrante, 2007, Obesity-induced inflammation: a metabolic dialogue in the language of inflammation, J. Intern. Med., 262, 408, 10.1111/j.1365-2796.2007.01852.x

Solinas, 2010, JNK1 and IKKbeta: molecular links between obesity and metabolic dysfunction, FASEB J., 24, 2596, 10.1096/fj.09-151340

Odegaard, 2013, Pleiotropic actions of insulin resistance and inflammation in metabolic homeostasis, Science, 339, 172, 10.1126/science.1230721

Walther, 2012, Lipid droplets and cellular lipid metabolism, Annu. Rev. Biochem., 81, 687, 10.1146/annurev-biochem-061009-102430

Herrero, 2010, Inflammation and adipose tissue macrophages in lipodystrophic mice, Proc. Natl. Acad. Sci. U. S. A., 107, 240, 10.1073/pnas.0905310107

Ouchi, 2011, Adipokines in inflammation and metabolic disease, Nat. Rev. Immunol., 11, 85, 10.1038/nri2921

Kondo, 2003, Biology of hematopoietic stem cells and progenitors: implications for clinical application, Annu. Rev. Immunol., 21, 759, 10.1146/annurev.immunol.21.120601.141007

Gordon, 2005, Monocyte and macrophage heterogeneity, Nat. Rev. Immunol., 5, 953, 10.1038/nri1733

Murdoch, 2008, The role of myeloid cells in the promotion of tumour angiogenesis, Nat. Rev. Cancer, 8, 618, 10.1038/nrc2444

Glass, 2012, Inflammation and lipid signaling in the etiology of insulin resistance, Cell Metab., 15, 635, 10.1016/j.cmet.2012.04.001

Kanda, 2006, MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity, J. Clin. Invest., 116, 1494, 10.1172/JCI26498

Kamei, 2006, Overexpression of monocyte chemoattractant protein-1 in adipose tissues causes macrophage recruitment and insulin resistance, J. Biol. Chem., 281, 26602, 10.1074/jbc.M601284200

Lumeng, 2007, Obesity induces a phenotypic switch in adipose tissue macrophage polarization, J. Clin. Invest., 117, 175, 10.1172/JCI29881

Dominguez, 2010, Differentiation and function of mouse monocyte-derived dendritic cells in steady state and inflammation, Immunol. Rev., 234, 90, 10.1111/j.0105-2896.2009.00876.x

Gautier, 2012, Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages, Nat. Immunol., 13, 1118, 10.1038/ni.2419

Hashimoto, 2011, Dendritic cell and macrophage heterogeneity in vivo, Immunity, 35, 323, 10.1016/j.immuni.2011.09.007

Shaul, 2010, Dynamic, M2-like remodeling phenotypes of CD11c+ adipose tissue macrophages during high-fat diet-induced obesity in mice, Diabetes, 59, 1171, 10.2337/db09-1402

Gordon, 2003, Alternative activation of macrophages, Nat. Rev. Immunol., 3, 23, 10.1038/nri978

Bourlier, 2008, Remodeling phenotype of human subcutaneous adipose tissue macrophages, Circulation, 117, 806, 10.1161/CIRCULATIONAHA.107.724096

Mayi, 2012, Human adipose tissue macrophages display activation of cancer-related pathways, J. Biol. Chem., 287, 21904, 10.1074/jbc.M111.315200

Cinti, 2005, Adipocyte death defines macrophage localization and function in adipose tissue of obese mice and humans, J. Lipid Res., 46, 2347, 10.1194/jlr.M500294-JLR200

Steinman, 2008, Dendritic cells in vivo: a key target for a new vaccine science, Immunity, 29, 319, 10.1016/j.immuni.2008.08.001

Patsouris, 2008, Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals, Cell Metab., 8, 301, 10.1016/j.cmet.2008.08.015

Stefanovic-Racic, 2012, Dendritic cells promote macrophage infiltration and comprise a substantial proportion of obesity-associated increases in CD11c+ cells in adipose tissue and liver, Diabetes, 61, 2330, 10.2337/db11-1523

Bertola, 2012, Identification of adipose tissue dendritic cells correlated with obesity-associated insulin-resistance and inducing Th17 responses in mice and patients, Diabetes, 61, 2238, 10.2337/db11-1274

Jaensson, 2008, Small intestinal CD103+ dendritic cells display unique functional properties that are conserved between mice and humans, J. Exp. Med., 205, 2139, 10.1084/jem.20080414

Winer, 2011, B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies, Nat. Med., 17, 610, 10.1038/nm.2353

DeFuria, 2013, B cells promote inflammation in obesity and type 2 diabetes through regulation of T cell function and an inflammatory cytokine profile, Proc. Natl. Acad. Sci. U. S. A., 110, 5133, 10.1073/pnas.1215840110

Mantovani, 2011, Neutrophils in the activation and regulation of innate and adaptive immunity, Nat. Rev. Immunol., 11, 519, 10.1038/nri3024

Amulic, 2012, Neutrophil function: from mechanisms to disease, Annu. Rev. Immunol., 30, 459, 10.1146/annurev-immunol-020711-074942

Nathan, 2006, Neutrophils and immunity: challenges and opportunities, Nat. Rev. Immunol., 6, 173, 10.1038/nri1785

Elgazar-Carmon, 2008, Neutrophils transiently infiltrate intra-abdominal fat early in the course of high-fat feeding, J. Lipid Res., 49, 1894, 10.1194/jlr.M800132-JLR200

Talukdar, 2012, Neutrophils mediate insulin resistance in mice fed a high-fat diet through secreted elastase, Nat. Med., 18, 1407, 10.1038/nm.2885

Spencer, 2010, Eosinophils and Th2 immunity: contemporary insights, Immunol. Cell Biol., 88, 250, 10.1038/icb.2009.115

Rothenberg, 2006, The eosinophil, Annu. Rev. Immunol., 24, 147, 10.1146/annurev.immunol.24.021605.090720

Ricardo-Gonzalez, 2010, IL-4/STAT6 immune axis regulates peripheral nutrient metabolism and insulin sensitivity, Proc. Natl. Acad. Sci. U. S. A., 107, 22617, 10.1073/pnas.1009152108

Wu, 2011, Eosinophils sustain adipose alternatively activated macrophages associated with glucose homeostasis, Science, 332, 243, 10.1126/science.1201475

Abraham, 2010, Mast cell-orchestrated immunity to pathogens, Nat. Rev. Immunol., 10, 440, 10.1038/nri2782

Galli, 2005, Mast cells as “tunable” effector and immunoregulatory cells: recent advances, Annu. Rev. Immunol., 23, 749, 10.1146/annurev.immunol.21.120601.141025

Liu, 2009, Genetic deficiency and pharmacological stabilization of mast cells reduce diet-induced obesity and diabetes in mice, Nat. Med., 15, 940, 10.1038/nm.1994

Koch, 2011, Mechanisms of T cell development and transformation, Annu. Rev. Cell Dev. Biol., 27, 539, 10.1146/annurev-cellbio-092910-154008

Oestreich, 2012, Master regulators or lineage-specifying? Changing views on CD4+ T cell transcription factors, Nat. Rev. Immunol., 12, 799, 10.1038/nri3321

Zhang, 2011, CD8(+) T cells: foot soldiers of the immune system, Immunity, 35, 161, 10.1016/j.immuni.2011.07.010

Winer, 2009, Normalization of obesity-associated insulin resistance through immunotherapy, Nat. Med., 15, 921, 10.1038/nm.2001

Rocha, 2008, Interferon-gamma, a Th1 cytokine, regulates fat inflammation: a role for adaptive immunity in obesity, Circ. Res., 103, 467, 10.1161/CIRCRESAHA.108.177105

Yang, 2010, Obesity increases the production of proinflammatory mediators from adipose tissue T cells and compromises TCR repertoire diversity: implications for systemic inflammation and insulin resistance, J. Immunol., 185, 1836, 10.4049/jimmunol.1000021

Nishimura, 2009, CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity, Nat. Med., 15, 914, 10.1038/nm.1964

Feuerer, 2009, Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters, Nat. Med., 15, 930, 10.1038/nm.2002

Josefowicz, 2012, Regulatory T cells: mechanisms of differentiation and function, Annu. Rev. Immunol., 30, 531, 10.1146/annurev.immunol.25.022106.141623

Cipolletta, 2012, PPAR-gamma is a major driver of the accumulation and phenotype of adipose tissue Treg cells, Nature, 486, 549, 10.1038/nature11132

De Libero, 2005, Recognition of lipid antigens by T cells, Nat. Rev. Immunol., 5, 485, 10.1038/nri1631

Lynch, 2012, Adipose tissue invariant NKT cells protect against diet-induced obesity and metabolic disorder through regulatory cytokine production, Immunity, 37, 574, 10.1016/j.immuni.2012.06.016

Wu, 2012, Activation of invariant natural killer T cells by lipid excess promotes tissue inflammation, insulin resistance, and hepatic steatosis in obese mice, Proc. Natl. Acad. Sci. U. S. A., 109, E1143, 10.1073/pnas.1200498109

Kotas, 2011, Impact of CD1d deficiency on metabolism, PLoS One, 6, e25478, 10.1371/journal.pone.0025478

Mantell, 2011, Mice lacking NKT cells but with a complete complement of CD8+ T-cells are not protected against the metabolic abnormalities of diet-induced obesity, PLoS One, 6, e19831, 10.1371/journal.pone.0019831

Ji, 2012, Short term high fat diet challenge promotes alternative macrophage polarization in adipose tissue via natural killer T cells and interleukin-4, J. Biol. Chem., 287, 24378, 10.1074/jbc.M112.371807

Ji, 2012, Activation of natural killer T cells promotes M2 Macrophage polarization in adipose tissue and improves systemic glucose tolerance via interleukin-4 (IL-4)/STAT6 protein signaling axis in obesity, J. Biol. Chem., 287, 13561, 10.1074/jbc.M112.350066

Ohmura, 2010, Natural killer T cells are involved in adipose tissues inflammation and glucose intolerance in diet-induced obese mice, Arterioscler. Thromb. Vasc. Biol., 30, 193, 10.1161/ATVBAHA.109.198614

Schipper, 2012, Natural killer T cells in adipose tissue prevent insulin resistance, J. Clin. Invest., 122, 3343, 10.1172/JCI62739

Huh, 2013, A novel function of adipocytes in lipid antigen presentation to iNKT cells, Mol. Cell. Biol., 33, 328, 10.1128/MCB.00552-12

Van Kaer, 2004, Natural killer T cells as targets for immunotherapy of autoimmune diseases, Immunol. Cell Biol., 82, 315, 10.1111/j.0818-9641.2004.01252.x

Carnaud, 1999, Cutting edge: cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells, J. Immunol., 163, 4647, 10.4049/jimmunol.163.9.4647

Singh, 1999, Cutting edge: activation of NK T cells by CD1d and alpha-galactosylceramide directs conventional T cells to the acquisition of a Th2 phenotype, J. Immunol., 163, 2373, 10.4049/jimmunol.163.5.2373

Matsuda, 2000, Tracking the response of natural killer T cells to a glycolipid antigen using CD1d tetramers, J. Exp. Med., 192, 741, 10.1084/jem.192.5.741

Eberl, 2000, Selective bystander proliferation of memory CD4+ and CD8+ T cells upon NK T or T cell activation, J. Immunol., 165, 4305, 10.4049/jimmunol.165.8.4305

Sidobre, 2002, The V alpha 14 NKT cell TCR exhibits high-affinity binding to a glycolipid/CD1d complex, J. Immunol., 169, 1340, 10.4049/jimmunol.169.3.1340

LeBien, 2008, B lymphocytes: how they develop and function, Blood, 112, 1570, 10.1182/blood-2008-02-078071

Mauri, 2012, Immune regulatory function of B cells, Annu. Rev. Immunol., 30, 221, 10.1146/annurev-immunol-020711-074934

Oeckinghaus, 2011, Crosstalk in NF-kappaB signaling pathways, Nat. Immunol., 12, 695, 10.1038/ni.2065

Ghosh, 2012, NF-kappaB regulation: lessons from structures, Immunol. Rev., 246, 36, 10.1111/j.1600-065X.2012.01097.x

Arkan, 2005, IKK-beta links inflammation to obesity-induced insulin resistance, Nat. Med., 11, 191, 10.1038/nm1185

Beutler, 2009, TLRs and innate immunity, Blood, 113, 1399, 10.1182/blood-2008-07-019307

Shi, 2006, TLR4 links innate immunity and fatty acid-induced insulin resistance, J. Clin. Invest., 116, 3015, 10.1172/JCI28898

Lee, 2001, Saturated fatty acids, but not unsaturated fatty acids, induce the expression of cyclooxygenase-2 mediated through Toll-like receptor 4, J. Biol. Chem., 276, 16683, 10.1074/jbc.M011695200

Tsukumo, 2007, Loss-of-function mutation in Toll-like receptor 4 prevents diet-induced obesity and insulin resistance, Diabetes, 56, 1986, 10.2337/db06-1595

Holland, 2011, Lipid-induced insulin resistance mediated by the proinflammatory receptor TLR4 requires saturated fatty acid-induced ceramide biosynthesis in mice, J. Clin. Invest., 121, 1858, 10.1172/JCI43378

Saberi, 2009, Hematopoietic cell-specific deletion of toll-like receptor 4 ameliorates hepatic and adipose tissue insulin resistance in high-fat-fed mice, Cell Metab., 10, 419, 10.1016/j.cmet.2009.09.006

Orr, 2012, Toll-like receptor 4 deficiency promotes the alternative activation of adipose tissue macrophages, Diabetes, 61, 2718, 10.2337/db11-1595

Hosoi, 2010, Myeloid differentiation factor 88 (MyD88)-deficiency increases risk of diabetes in mice, PLoS One, 5, e12537, 10.1371/journal.pone.0012537

Bogoyevitch, 2010, c-Jun N-terminal kinase (JNK) signaling: recent advances and challenges, Biochim. Biophys. Acta, 1804, 463, 10.1016/j.bbapap.2009.11.002

Hotamisligil, 2010, Endoplasmic reticulum stress and the inflammatory basis of metabolic disease, Cell, 140, 900, 10.1016/j.cell.2010.02.034

Hirosumi, 2002, A central role for JNK in obesity and insulin resistance, Nature, 420, 333, 10.1038/nature01137

Jaeschke, 2004, An essential role of the JIP1 scaffold protein for JNK activation in adipose tissue, Genes Dev., 18, 1976, 10.1101/gad.1216504

Solinas, 2007, JNK1 in hematopoietically derived cells contributes to diet-induced inflammation and insulin resistance without affecting obesity, Cell Metab., 6, 386, 10.1016/j.cmet.2007.09.011

Vallerie, 2008, A predominant role for parenchymal c-Jun amino terminal kinase (JNK) in the regulation of systemic insulin sensitivity, PLoS One, 3, e3151, 10.1371/journal.pone.0003151

Sabio, 2008, A stress signaling pathway in adipose tissue regulates hepatic insulin resistance, Science, 322, 1539, 10.1126/science.1160794

Han, 2013, JNK expression by macrophages promotes obesity-induced insulin resistance and inflammation, Science, 339, 218, 10.1126/science.1227568

Strowig, 2012, Inflammasomes in health and disease, Nature, 481, 278, 10.1038/nature10759

Davis, 2011, The inflammasome NLRs in immunity, inflammation, and associated diseases, Annu. Rev. Immunol., 29, 707, 10.1146/annurev-immunol-031210-101405

Duewell, 2010, NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals, Nature, 464, 1357, 10.1038/nature08938

Wen, 2011, Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling, Nat. Immunol., 12, 408, 10.1038/ni.2022

Vandanmagsar, 2011, The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance, Nat. Med., 17, 179, 10.1038/nm.2279

Stienstra, 2011, Inflammasome is a central player in the induction of obesity and insulin resistance, Proc. Natl. Acad. Sci. U. S. A., 108, 15324, 10.1073/pnas.1100255108

Jager, 2007, Interleukin-1beta-induced insulin resistance in adipocytes through down-regulation of insulin receptor substrate-1 expression, Endocrinology, 148, 241, 10.1210/en.2006-0692

Lagathu, 2006, Long-term treatment with interleukin-1beta induces insulin resistance in murine and human adipocytes, Diabetologia, 49, 2162, 10.1007/s00125-006-0335-z

Osborn, 2008, Treatment with an Interleukin 1 beta antibody improves glycemic control in diet-induced obesity, Cytokine, 44, 141, 10.1016/j.cyto.2008.07.004

Larsen, 2007, Interleukin-1-receptor antagonist in type 2 diabetes mellitus, N. Engl. J. Med., 356, 1517, 10.1056/NEJMoa065213

Ridker, 2012, Effects of interleukin-1beta inhibition with canakinumab on hemoglobin A1c, lipids, C-reactive protein, interleukin-6, and fibrinogen: a phase IIb randomized, placebo-controlled trial, Circulation, 126, 2739, 10.1161/CIRCULATIONAHA.112.122556

Rui, 2001, Insulin/IGF-1 and TNF-alpha stimulate phosphorylation of IRS-1 at inhibitory Ser307 via distinct pathways, J. Clin. Invest., 107, 181, 10.1172/JCI10934

Ofei, 1996, Effects of an engineered human anti-TNF-alpha antibody (CDP571) on insulin sensitivity and glycemic control in patients with NIDDM, Diabetes, 45, 881, 10.2337/diab.45.7.881

Paquot, 2000, No increased insulin sensitivity after a single intravenous administration of a recombinant human tumor necrosis factor receptor: Fc fusion protein in obese insulin-resistant patients, J. Clin. Endocrinol. Metab., 85, 1316

Hong, 2009, Interleukin-10 prevents diet-induced insulin resistance by attenuating macrophage and cytokine response in skeletal muscle, Diabetes, 58, 2525, 10.2337/db08-1261

Wallenius, 2002, Interleukin-6-deficient mice develop mature-onset obesity, Nat. Med., 8, 75, 10.1038/nm0102-75

Fujisaka, 2009, Regulatory mechanisms for adipose tissue M1 and M2 macrophages in diet-induced obese mice, Diabetes, 58, 2574, 10.2337/db08-1475

Kowalski, 2011, Deficiency of haematopoietic-cell-derived IL-10 does not exacerbate high-fat-diet-induced inflammation or insulin resistance in mice, Diabetologia, 54, 888, 10.1007/s00125-010-2020-5

Honda, 2012, The microbiome in infectious disease and inflammation, Annu. Rev. Immunol., 30, 759, 10.1146/annurev-immunol-020711-074937

Tilg, 2011, Gut microbiome, obesity, and metabolic dysfunction, J. Clin. Invest., 121, 2126, 10.1172/JCI58109

Odegaard, 2007, Macrophage-specific PPARgamma controls alternative activation and improves insulin resistance, Nature, 447, 1116, 10.1038/nature05894

Marathe, 2009, Preserved glucose tolerance in high-fat-fed C57BL/6 mice transplanted with PPARgamma−/−, PPARdelta−/−, PPARgammadelta−/−, or LXRalphabeta−/− bone marrow, J. Lipid Res., 50, 214, 10.1194/jlr.M800189-JLR200

Caricilli, 2011, Gut microbiota is a key modulator of insulin resistance in TLR 2 knockout mice, PLoS Biol., 9, e1001212, 10.1371/journal.pbio.1001212

Zhang, 2011, Selective inactivation of c-Jun NH2-terminal kinase in adipose tissue protects against diet-induced obesity and improves insulin sensitivity in both liver and skeletal muscle in mice, Diabetes, 60, 486, 10.2337/db10-0650

Barra, 2010, Interleukin-15 contributes to the regulation of murine adipose tissue and human adipocytes, Obesity (Silver Spring), 18, 1601, 10.1038/oby.2009.445

Chang, 2012, Regulation of glucose/lipid metabolism and insulin sensitivity by interleukin-4, Int. J. Obes. (Lond), 36, 993, 10.1038/ijo.2011.168

McGillicuddy, 2011, Lack of interleukin-1 receptor I (IL-1RI) protects mice from high-fat diet-induced adipose tissue inflammation coincident with improved glucose homeostasis, Diabetes, 60, 1688, 10.2337/db10-1278

Morris, 2012, CX3CR1 deficiency does not influence trafficking of adipose tissue macrophages in mice with diet-induced obesity, Obesity, 20, 1189, 10.1038/oby.2012.7

Nomiyama, 2007, Osteopontin mediates obesity-induced adipose tissue macrophage infiltration and insulin resistance in mice, J. Clin. Invest., 117, 2877, 10.1172/JCI31986

Weisberg, 2006, CCR2 modulates inflammatory and metabolic effects of high-fat feeding, J. Clin. Invest., 116, 115, 10.1172/JCI24335

Chavey, 2009, CXC ligand 5 is an adipose-tissue derived factor that links obesity to insulin resistance, Cell Metab., 9, 339, 10.1016/j.cmet.2009.03.002

Kang, 2008, Adipocyte-derived Th2 cytokines and myeloid PPARdelta regulate macrophage polarization and insulin sensitivity, Cell Metab., 7, 485, 10.1016/j.cmet.2008.04.002

Kurokawa, 2011, Apoptosis inhibitor of macrophage (AIM) is required for obesity-associated recruitment of inflammatory macrophages into adipose tissue, Proc. Natl. Acad. Sci. U. S. A., 108, 12072, 10.1073/pnas.1101841108

Watanabe, 2012, The radioprotective 105/MD-1 complex contributes to diet-induced obesity and adipose tissue inflammation, Diabetes, 61, 1199, 10.2337/db11-1182

Westcott, 2009, MGL1 promotes adipose tissue inflammation and insulin resistance by regulating 7/4hi monocytes in obesity, J. Exp. Med., 206, 3143, 10.1084/jem.20091333

Nicholls, 2011, Hematopoietic cell-restricted deletion of CD36 reduces high-fat diet-induced macrophage infiltration and improves insulin signaling in adipose tissue, Diabetes, 60, 1100, 10.2337/db10-1353

Spite, 2011, Deficiency of the leukotriene B4 receptor, BLT-1, protects against systemic insulin resistance in diet-induced obesity, J. Immunol., 187, 1942, 10.4049/jimmunol.1100196

Sachithanandan, 2011, Macrophage deletion of SOCS1 increases sensitivity to LPS and palmitic acid and results in systemic inflammation and hepatic insulin resistance, Diabetes, 60, 2023, 10.2337/db11-0259

Mauer, 2010, Myeloid cell-restricted insulin receptor deficiency protects against obesity-induced inflammation and systemic insulin resistance, PLoS Genet., 6, e1000938, 10.1371/journal.pgen.1000938

Zhu, 2008, Increased cellular free cholesterol in macrophage-specific Abca1 knock-out mice enhances pro-inflammatory response of macrophages, J. Biol. Chem., 283, 22930, 10.1074/jbc.M801408200

Lesniewski, 2007, Bone marrow-specific Cap gene deletion protects against high-fat diet-induced insulin resistance, Nat. Med., 13, 455, 10.1038/nm1550

Furuhashi, 2008, Adipocyte/macrophage fatty acid-binding proteins contribute to metabolic deterioration through actions in both macrophages and adipocytes in mice, J. Clin. Invest., 118, 2640

Liao, 2011, Kruppel-like factor 4 regulates macrophage polarization, J. Clin. Invest., 121, 2736, 10.1172/JCI45444

Feral, 2008, Blockade of alpha4 integrin signaling ameliorates the metabolic consequences of high-fat diet-induced obesity, Diabetes, 57, 1842, 10.2337/db07-1751

Oh, 2010, GPR120 is an omega-3 fatty acid receptor mediating potent anti-inflammatory and insulin-sensitizing effects, Cell, 142, 687, 10.1016/j.cell.2010.07.041