Cellular Specificity of NF-κB Function in the Nervous System

Erica C. Dresselhaus1, Mollie K. Meffert1
1Department of Biological Chemistry and Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, United States

Tóm tắt

Từ khóa


Tài liệu tham khảo

Hayden, 2012, NF-kappaB, the first quarter-century: remarkable progress and outstanding questions, Genes Dev, 26, 203, 10.1101/gad.183434.111

Zhang, 2017, 30 years of NF-kappaB: a blossoming of relevance to human pathobiology, Cell, 168, 37, 10.1016/j.cell.2016.12.012

Hayden, 2008, Shared principles in NF-kappaB signaling, Cell, 132, 344, 10.1016/j.cell.2008.01.020

Van Antwerp, 1996, Suppression of TNF-alpha-induced apoptosis by NF-kappaB, Science, 274, 787, 10.1126/science.274.5288.787

Zeisel, 2018, Molecular architecture of the mouse nervous system, Cell, 174, 999, 10.1016/j.cell.2018.06.021

Snow, 2016, Neuronal gene targets of NF-kappaB and their dysregulation in Alzheimer's disease, Front Mol Neurosci, 9, 118, 10.3389/fnmol.2016.00118

Kassed, 2004, NF-kappaB p50-deficient mice show reduced anxiety-like behaviors in tests of exploratory drive and anxiety, Behav Brain Res, 154, 577, 10.1016/j.bbr.2004.03.026

Kassed, 2002, Lack of NF-kappaB p50 exacerbates degeneration of hippocampal neurons after chemical exposure and impairs learning, Exp Neurol, 176, 277, 10.1006/exnr.2002.7967

Oikawa, 2012, NF-kappaB p50 subunit knockout impairs late LTP and alters long term memory in the mouse hippocampus, BMC Neurosci, 13, 45, 10.1186/1471-2202-13-45

Ahn, 2008, c-Rel, an NF-kappaB family transcription factor, is required for hippocampal long-term synaptic plasticity and memory formation, Learn Mem, 15, 539, 10.1101/lm.866408

Levenson, 2004, A bioinformatics analysis of memory consolidation reveals involvement of the transcription factor c-rel, J Neurosci, 24, 3933, 10.1523/JNEUROSCI.5646-03.2004

O'Riordan, 2006, Regulation of nuclear factor kappaB in the hippocampus by group I metabotropic glutamate receptors, J Neurosci, 26, 4870, 10.1523/JNEUROSCI.4527-05.2006

Meffert, 2003, NF-kappa B functions in synaptic signaling and behavior, Nat Neurosci, 6, 1072, 10.1038/nn1110

Neidl, 2016, Late-life environmental enrichment induces acetylation events and nuclear factor kappab-dependent regulations in the hippocampus of aged rats showing improved plasticity and learning, J Neurosci, 36, 4351, 10.1523/JNEUROSCI.3239-15.2016

Lubin, 2007, The IkappaB kinase regulates chromatin structure during reconsolidation of conditioned fear memories, Neuron, 55, 942, 10.1016/j.neuron.2007.07.039

Fridmacher, 2003, Forebrain-specific neuronal inhibition of nuclear factor-kappaB activity leads to loss of neuroprotection, J Neurosci, 23, 9403, 10.1523/JNEUROSCI.23-28-09403.2003

O'Mahony, 2006, NF-kappaB/Rel regulates inhibitory and excitatory neuronal function and synaptic plasticity, Mol Cell Biol, 26, 7283, 10.1128/MCB.00510-06

de la Fuente, 2015, NF-kappaB transcription factor role in consolidation and reconsolidation of persistent memories, Front Mol Neurosci, 8, 50, 10.3389/fnmol.2015.00050

Shrum, 2008, The NF-kB family in learning and memory, Learning And Memory: A Comprehensive Reference, 4, 567

Kaltschmidt, 2015, NF-KappaB in long-term memory and structural plasticity in the adult mammalian brain, Front Mol Neurosci, 8, 69, 10.3389/fnmol.2015.00069

Uchida, 2018, Synaptically localized transcriptional regulators in memory formation, Neuroscience, 370, 4, 10.1016/j.neuroscience.2017.07.023

Kyrargyri, 2015, Differential contributions of microglial and neuronal IKKbeta to synaptic plasticity and associative learning in alert behaving mice, Glia, 63, 549, 10.1002/glia.22756

Boersma, 2011, A requirement for nuclear factor-kappaB in developmental and plasticity-associated synaptogenesis, J Neurosci, 31, 5414, 10.1523/JNEUROSCI.2456-10.2011

Mihalas, 2013, Opposing action of nuclear factor kappaB and Polo-like kinases determines a homeostatic end point for excitatory synaptic adaptation, J Neurosci, 33, 16490, 10.1523/JNEUROSCI.2131-13.2013

Kaltschmidt, 1995, Stimulation of ionotropic glutamate receptors activates transcription factor NF-kappa B in primary neurons, Proc Natl Acad Sci USA, 92, 9618, 10.1073/pnas.92.21.9618

Guerrini, 1995, Synaptic activation of NF-kappa B by glutamate in cerebellar granule neurons in vitro, Proc Natl Acad Sci USA, 92, 9077, 10.1073/pnas.92.20.9077

Guerrini, 1997, Glutamate-dependent activation of NF-kappaB during mouse cerebellum development, J Neurosci, 17, 6057, 10.1523/JNEUROSCI.17-16-06057.1997

Caccamo, 2005, Glutamate promotes NF-kappaB pathway in primary astrocytes: protective effects of IRFI 016, a synthetic vitamin E analogue, Exp Neurol, 193, 377, 10.1016/j.expneurol.2005.01.014

Sitcheran, 2008, Essential role for epidermal growth factor receptor in glutamate receptor signaling to NF-kappaB, Mol Cell Biol, 28, 5061, 10.1128/MCB.00578-08

Meffert, 2005, Physiological functions for brain NF-kappaB, Trends Neurosci, 28, 37, 10.1016/j.tins.2004.11.002

Lilienbaum, 2003, From calcium to NF-kappa B signaling pathways in neurons, Mol Cell Biol, 23, 2680, 10.1128/MCB.23.8.2680-2698.2003

Mihalas, 2015, IKK kinase assay for assessment of canonical NF-kappaB activation in neurons, Methods Mol Biol, 1280, 61, 10.1007/978-1-4939-2422-6_5

Cruise, 2000, Kainate receptors activate NF-kappaB via MAP kinase in striatal neurones, Neuroreport, 11, 395, 10.1097/00001756-200002070-00034

Hughes, 2001, Calmodulin-dependent kinase II mediates T cell receptor/CD3- and phorbol ester-induced activation of IkappaB kinase, J Biol Chem, 276, 36008, 10.1074/jbc.M106125200

Ling, 2013, Ca2+/Calmodulin-dependent protein kinase II delta mediates myocardial ischemia/reperfusion injury through nuclear factor-kappaB, Circ Res, 112, 935, 10.1161/CIRCRESAHA.112.276915

Martin, 2018, CaMKIIdelta interacts directly with IKKbeta and modulates NF-kappaB signalling in adult cardiac fibroblasts, Cell Signal, 51, 166, 10.1016/j.cellsig.2018.07.008

Fan, 2009, Glutamate-induced NFkappaB activation in the retina, Invest Ophthalmol Vis Sci, 50, 917, 10.1167/iovs.08-2555

Shrum, 2009, Stimulated nuclear translocation of NF-kappaB and shuttling differentially depend on dynein and the dynactin complex, Proc Natl Acad Sci USA, 106, 2647, 10.1073/pnas.0806677106

Widera, 2016, Single-particle tracking uncovers dynamics of glutamate-induced retrograde transport of NF-kappaB p65 in living neurons, Neurophotonics, 3, 041804, 10.1117/1.NPh.3.4.041804

Mikenberg, 2007, Transcription factor NF-kappaB is transported to the nucleus via cytoplasmic dynein/dynactin motor complex in hippocampal neurons, PLoS ONE, 2, e589, 10.1371/journal.pone.0000589

Kaltschmidt, 1993, Brain synapses contain inducible forms of the transcription factor NF- kappa B, Mech Dev, 43, 135, 10.1016/0925-4773(93)90031-R

Meberg, 1996, Gene expression of the transcription factor NF-kappa B in hippocampus: regulation by synaptic activity, Brain Res Mol Brain Res, 38, 179, 10.1016/0169-328X(95)00229-L

Salles, 2015, Hippocampal dynamics of synaptic NF-kappa B during inhibitory avoidance long-term memory consolidation in mice, Neuroscience, 291, 70, 10.1016/j.neuroscience.2015.01.063

Dresselhaus, 2018, Targeting of NF-kappaB to dendritic spines is required for synaptic signaling and spine development, J Neurosci, 38, 4093, 10.1523/JNEUROSCI.2663-16.2018

Marcora, 2010, The Huntington's disease mutation impairs Huntingtin's role in the transport of NF-kappaB from the synapse to the nucleus, Hum Mol Genet, 19, 4373, 10.1093/hmg/ddq358

Konig, 2017, NF-kappaB regulates neuronal ankyrin-G via a negative feedback loop, Sci Rep, 7, 42006, 10.1038/srep42006

Schmeisser, 2012, IkappaB kinase/nuclear factor kappaB-dependent insulin-like growth factor 2 (Igf2) expression regulates synapse formation and spine maturation via Igf2 receptor signaling, J Neurosci, 32, 5688, 10.1523/JNEUROSCI.0111-12.2012

Kaltschmidt, 2006, NF-kappaB regulates spatial memory formation and synaptic plasticity through protein kinase A/CREB signaling, Mol Cell Biol, 26, 2936, 10.1128/MCB.26.8.2936-2946.2006

Li, 2013, Role of p300 in regulating neuronal nitric oxide synthase gene expression through nuclear factor-kappaB-mediated way in neuronal cells, Neuroscience, 248, 681, 10.1016/j.neuroscience.2013.06.030

Bhakar, 2002, Constitutive nuclear factor-kappa B activity is required for central neuron survival, J Neurosci, 22, 8466, 10.1523/JNEUROSCI.22-19-08466.2002

Schmidt-Ullrich, 1996, NF-kappaB activity in transgenic mice: developmental regulation and tissue specificity, Development, 122, 2117, 10.1242/dev.122.7.2117

Xiao, 2018, Lymphotoxin beta receptor-mediated NFkappaB signaling promotes glial lineage differentiation and inhibits neuronal lineage differentiation in mouse brain neural stem/progenitor cells, J Neuroinflammation, 15, 49, 10.1186/s12974-018-1074-z

Cherry, 2015, Tumor necrosis factor-like weak inducer of apoptosis (TWEAK) promotes glioma cell invasion through induction of NF-kappaB-inducing kinase (NIK) and noncanonical NF-kappaB signaling, Mol Cancer, 14, 9, 10.1186/s12943-014-0273-1

Gupta, 2019, RelB controls adaptive responses of astrocytes during sterile inflammation, Glia., 10.1002/glia.23619

Simmons, 2016, Regulation of inflammatory responses by neuregulin-1 in brain ischemia and microglial cells in vitro involves the NF-kappa B pathway, J Neuroinflammation, 13, 237, 10.1186/s12974-016-0703-7

Kiebala, 2010, Nuclear factor-kappa B family member RelB inhibits human immunodeficiency virus-1 Tat-induced tumor necrosis factor-alpha production, PLoS ONE, 5, e11875, 10.1371/journal.pone.0011875

Block, 2007, Microglia-mediated neurotoxicity: uncovering the molecular mechanisms, Nat Rev Neurosci, 8, 57, 10.1038/nrn2038

Cho, 2008, Role of microglial IKKbeta in kainic acid-induced hippocampal neuronal cell death, Brain, 131, 3019, 10.1093/brain/awn230

Voet, 2018, A20 critically controls microglia activation and inhibits inflammasome-dependent neuroinflammation, Nat Commun, 9, 2036, 10.1038/s41467-018-04376-5

Parkhurst, 2013, Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor, Cell, 155, 1596, 10.1016/j.cell.2013.11.030

Miyamoto, 2016, Microglia contact induces synapse formation in developing somatosensory cortex, Nat Commun, 7, 12540, 10.1038/ncomms12540

Brambilla, 2005, Inhibition of astroglial nuclear factor kappaB reduces inflammation and improves functional recovery after spinal cord injury, J Exp Med, 202, 145, 10.1084/jem.20041918

Brambilla, 2012, Transgenic inhibition of astroglial NF-kappaB protects from optic nerve damage and retinal ganglion cell loss in experimental optic neuritis, J Neuroinflammation, 9, 213, 10.1186/1742-2094-9-213

Brambilla, 2009, Transgenic inhibition of astroglial NF-kappa B leads to increased axonal sparing and sprouting following spinal cord injury, J Neurochem, 110, 765, 10.1111/j.1471-4159.2009.06190.x

Ghosh, 2011, Nuclear factor-kappaB contributes to neuron-dependent induction of glutamate transporter-1 expression in astrocytes, J Neurosci, 31, 9159, 10.1523/JNEUROSCI.0302-11.2011

Zhang, 2017, Astrocytic process plasticity and IKKbeta/NF-kappaB in central control of blood glucose, blood pressure, and body weight, Cell Metab, 25, 1091, 10.1016/j.cmet.2017.04.002

Srinivasan, 2016, New transgenic mouse lines for selectively targeting astrocytes and studying calcium signals in astrocyte processes in situ and in vivo, Neuron, 92, 1181, 10.1016/j.neuron.2016.11.030

Zhang, 2012, Nuclear factor kappa B signaling initiates early differentiation of neural stem cells, Stem Cells, 30, 510, 10.1002/stem.1006

Bracchi-Ricard, 2008, Astroglial nuclear factor-kappaB regulates learning and memory and synaptic plasticity in female mice, J Neurochem, 104, 611, 10.1111/j.1471-4159.2007.04993.x

Wang, 1999, NF-kappaB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis, Mol Cell Biol, 19, 5923, 10.1128/MCB.19.9.5923

Wang, 1998, NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation, Science, 281, 1680, 10.1126/science.281.5383.1680

Grumont, 1999, Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis, Genes Dev, 13, 400, 10.1101/gad.13.4.400

Chen, 2000, The Rel/NF-kappaB family directly activates expression of the apoptosis inhibitor Bcl-x(L), Mol Cell Biol, 20, 2687, 10.1128/MCB.20.8.2687-2695.2000

Zong, 1999, The prosurvival Bcl-2 homolog Bfl-1/A1 is a direct transcriptional target of NF-kappaB that blocks TNFalpha-induced apoptosis, Genes Dev, 13, 382, 10.1101/gad.13.4.382

Tamatani, 1999, Tumor necrosis factor induces Bcl-2 and Bcl-x expression through NFkappaB activation in primary hippocampal neurons, J Biol Chem, 274, 8531, 10.1074/jbc.274.13.8531

Yabe, 2001, NFkappaB activation is required for the neuroprotective effects of pigment epithelium-derived factor (PEDF) on cerebellar granule neurons, J Biol Chem, 276, 43313, 10.1074/jbc.M107831200

Mincheva, 2011, The canonical nuclear factor-kappaB pathway regulates cell survival in a developmental model of spinal cord motoneurons, J Neurosci, 31, 6493, 10.1523/JNEUROSCI.0206-11.2011

Mettang, 2018, IKK2/NF-kappaB signaling protects neurons after traumatic brain injury, FASEB J, 32, 1916, 10.1096/fj.201700826R

Shih, 2015, NF-kappaB signaling pathways in neurological inflammation: a mini review, Front Mol Neurosci, 8, 77, 10.3389/fnmol.2015.00077

De Strooper, 2016, The cellular phase of Alzheimer's disease, Cell, 164, 603, 10.1016/j.cell.2015.12.056

Giri, 2016, Genes associated with Alzheimer's disease: an overview and current status, Clin Interv Aging, 11, 665, 10.2147/CIA.S105769

Du, 2005, NF-(kappa)B mediates amyloid beta peptide-stimulated activity of the human apolipoprotein E gene promoter in human astroglial cells, Brain Res Mol Brain Res, 136, 177, 10.1016/j.molbrainres.2005.02.001

Chami, 2012, Nuclear factor-kappaB regulates betaAPP and beta- and gamma-secretases differently at physiological and supraphysiological Abeta concentrations, J Biol Chem, 287, 24573, 10.1074/jbc.M111.333054

Owens, 2017, Divergent neuroinflammatory regulation of microglial TREM expression and involvement of NF-kappaB, Front Cell Neurosci, 11, 56, 10.3389/fncel.2017.00056

Kumar, 2016, Binding of transcription factors to Presenilin 1 and 2 promoter cis-acting elements varies during the development of mouse cerebral cortex, Neurosci Lett, 628, 98, 10.1016/j.neulet.2016.05.013

Tanaka, 2018, Presenilin 1 regulates NF-kappaB activation via association with breakpoint cluster region and casein kinase II, J Immunol, 201, 2256, 10.4049/jimmunol.1701446

Wang, 2018, Genome-wide RNAseq study of the molecular mechanisms underlying microglia activation in response to pathological tau perturbation in the rTg4510 tau transgenic animal model, Mol Neurodegener, 13, 65, 10.1186/s13024-018-0296-y

Colonna, 2016, TREM2 variants: new keys to decipher Alzheimer disease pathogenesis, Nat Rev Neurosci, 17, 201, 10.1038/nrn.2016.7

Guerreiro, 2013, TREM2 variants in Alzheimer's disease, N Engl J Med, 368, 117, 10.1056/NEJMoa1211851

Keren-Shaul, 2017, A unique microglia type associated with restricting development of Alzheimer's disease, Cell, 169, 1276, 10.1016/j.cell.2017.05.018

Ulland, 2017, TREM2 maintains microglial metabolic fitness in Alzheimer's disease, Cell, 170, 649, 10.1016/j.cell.2017.07.023

Hong, 2017, TREM2: keeping microglia fit during good times and bad, Cell Metab, 26, 590, 10.1016/j.cmet.2017.09.010

Hong, 2016, Complement and microglia mediate early synapse loss in Alzheimer mouse models, Science, 352, 712, 10.1126/science.aad8373

Hong, 2016, Microglia: phagocytosing to clear, sculpt, and eliminate, Dev Cell, 38, 126, 10.1016/j.devcel.2016.07.006

Lahiri, 2004, Apolipoprotein E as a target for developing new therapeutics for Alzheimer's disease based on studies from protein, RNA, and regulatory region of the gene, J Mol Neurosci, 23, 225, 10.1385/JMN:23:3:225

Jones, 2017, Nuclear Factor-Kappa B and Alzheimer disease, unifying genetic and environmental risk factors from cell to humans, Front Immunol, 8, 1805, 10.3389/fimmu.2017.01805

Bates, 2015, Huntington disease, Nat Rev Dis Primers, 1, 15005, 10.1038/nrdp.2015.5

Takano, 2002, The predominantly HEAT-like motif structure of huntingtin and its association and coincident nuclear entry with dorsal, an NF-kB/Rel/dorsal family transcription factor, BMC Neurosci, 3, 15, 10.1186/1471-2202-3-15

Caviston, 2007, Huntingtin facilitates dynein/dynactin-mediated vesicle transport, Proc Natl Acad Sci USA, 104, 10045, 10.1073/pnas.0610628104

Gauthier, 2004, Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules, Cell, 118, 127, 10.1016/j.cell.2004.06.018

Trushina, 2004, Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro, Mol Cell Biol, 24, 8195, 10.1128/MCB.24.18.8195-8209.2004

Hsiao, 2013, A critical role of astrocyte-mediated nuclear factor-kappaB-dependent inflammation in Huntington's disease, Hum Mol Genet, 22, 1826, 10.1093/hmg/ddt036

Khoshnan, 2004, Activation of the IkappaB kinase complex and nuclear factor-kappaB contributes to mutant huntingtin neurotoxicity, J Neurosci, 24, 7999, 10.1523/JNEUROSCI.2675-04.2004

Becanovic, 2015, A SNP in the HTT promoter alters NF-kappaB binding and is a bidirectional genetic modifier of Huntington disease, Nat Neurosci, 18, 807, 10.1038/nn.4014

Rojo, 2004, Regulation of Cu/Zn-superoxide dismutase expression via the phosphatidylinositol 3 kinase/Akt pathway and nuclear factor-kappaB, J Neurosci, 24, 7324, 10.1523/JNEUROSCI.2111-04.2004

Swarup, 2011, Deregulation of TDP-43 in amyotrophic lateral sclerosis triggers nuclear factor kappaB-mediated pathogenic pathways, J Exp Med, 208, 2429, 10.1084/jem.20111313

Maruyama, 2010, Mutations of optineurin in amyotrophic lateral sclerosis, Nature, 465, 223, 10.1038/nature08971

Frakes, 2014, Microglia induce motor neuron death via the classical NF-kappaB pathway in amyotrophic lateral sclerosis, Neuron, 81, 1009, 10.1016/j.neuron.2014.01.013

Ouali Alami, 2018, NF-kappaB activation in astrocytes drives a stage-specific beneficial neuroimmunological response in ALS, EMBO J, 37, e98697, 10.15252/embj.201798697

Dauer, 2003, Parkinson's disease: mechanisms and models, Neuron, 39, 889, 10.1016/S0896-6273(03)00568-3

Ghosh, 2007, Selective inhibition of NF-kappaB activation prevents dopaminergic neuronal loss in a mouse model of Parkinson's disease, Proc Natl Acad Sci USA, 104, 18754, 10.1073/pnas.0704908104

Hunot, 1997, Nuclear translocation of NF-kappaB is increased in dopaminergic neurons of patients with Parkinson disease, Proc Natl Acad Sci USA, 94, 7531, 10.1073/pnas.94.14.7531

Pizzi, 2005, NF-kappaB factor c-Rel mediates neuroprotection elicited by mGlu5 receptor agonists against amyloid beta-peptide toxicity, Cell Death Differ, 12, 761, 10.1038/sj.cdd.4401598

Baiguera, 2012, Late-onset Parkinsonism in NFkappaB/c-Rel-deficient mice, Brain, 135, 2750, 10.1093/brain/aws193

Sun, 2017, Cooperation of Rel family members in regulating Abeta1-40-mediated pro-inflammatory cytokine secretion by retinal pigment epithelial cells, Cell Death Dis, 8, e3115, 10.1038/cddis.2017.502

Clark, 2006, Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin, Nature, 441, 1162, 10.1038/nature04779

Park, 2006, Mitochondrial dysfunction in Drosophila PINK1 mutants is complemented by parkin, Nature, 441, 1157, 10.1038/nature04788

Yang, 2006, Mitochondrial pathology and muscle and dopaminergic neuron degeneration caused by inactivation of Drosophila Pink1 is rescued by Parkin, Proc Natl Acad Sci USA, 103, 10793, 10.1073/pnas.0602493103

Henn, 2007, Parkin mediates neuroprotection through activation of IkappaB kinase/nuclear factor-kappaB signaling, J Neurosci, 27, 1868, 10.1523/JNEUROSCI.5537-06.2007

Sha, 2010, Phosphorylation of parkin by Parkinson disease-linked kinase PINK1 activates parkin E3 ligase function and NF-kappaB signaling, Hum Mol Genet, 19, 352, 10.1093/hmg/ddp501

Tanji, 2010, TRIM9, a novel brain-specific E3 ubiquitin ligase, is repressed in the brain of Parkinson's disease and dementia with Lewy bodies, Neurobiol Dis, 38, 210, 10.1016/j.nbd.2010.01.007

Zeng, 2019, TRIM9-mediated resolution of neuroinflammation confers neuroprotection upon ischemic stroke in mice, Cell Rep, 27, 549, 10.1016/j.celrep.2018.12.055

Carrasco, 1993, Expression of relB transcripts during lymphoid organ development: specific expression in dendritic antigen-presenting cells, Development, 118, 1221, 10.1242/dev.118.4.1221