Cellular FADD-like IL-1β-converting enzyme-inhibitory protein attenuates myocardial ischemia/reperfusion injury via suppressing apoptosis and autophagy simultaneously

Neri, 2017, Ischemia/reperfusion injury following acute myocardial infarction: a critical issue for clinicians and forensic pathologists, Mediat Inflamm, 2017, 7018393, 10.1155/2017/7018393 Yellon, 2007, Myocardial reperfusion injury, N Engl J Med, 357, 1121, 10.1056/NEJMra071667 Ibáñez, 2015, Evolving therapies for myocardial ischemia/reperfusion injury, J Am Coll Cardiol, 65, 1454, 10.1016/j.jacc.2015.02.032 Hamacher-Brady, 2006, The Interplay between pro-death and pro-survival signaling pathways in myocardial ischemia/reperfusion injury: apoptosis meets autophagy, Cardiovasc Drugs Ther, 20, 445, 10.1007/s10557-006-0583-7 Zhu, 2015, The cardioprotective effect of salidroside against myocardial ischemia reperfusion injury in rats by inhibiting apoptosis and inflammation, Apoptosis, 20, 1433, 10.1007/s10495-015-1174-5 Ma, 2012, Impaired autophagosome clearance contributes to cardiomyocyte death in ischemia/reperfusion injury, Circulation, 125, 3170, 10.1161/CIRCULATIONAHA.111.041814 Weinlich, 2013, Protective roles for caspase-8 and cFLIP in adult homeostasis, Cell Rep, 5, 340, 10.1016/j.celrep.2013.08.045 Imanishi, 2000, Cellular FLIP is expressed in cardiomyocytes and down-regulated in TUNEL-positive grafted cardiac tissues, Cardiovasc Res, 48, 101, 10.1016/S0008-6363(00)00154-1 Li, 2010, Cellular FLICE-inhibitory protein protects against cardiac remodeling induced by angiotensin II in mice, Hypertension, 56, 1109, 10.1161/HYPERTENSIONAHA.110.157412 Lee, 2009, FLIP-mediated autophagy regulation in cell death control, Nat Cell Biol, 11, 1355, 10.1038/ncb1980 Ranjan, 2016, Expression of cFLIPL determines the basal interaction of Bcl-2 with Beclin-1 and regulates p53 dependent ubiquitination of Beclin-1 during Autophagic stress, J Cell Biochem, 117, 1757, 10.1002/jcb.25474 Zhou, 2015, Exendin-4 enhances the migration of adipose-derived stem cells to neonatal rat ventricular cardiomyocyte-derived conditioned medium via the phosphoinositide 3-kinase/Akt-stromal cell-derived factor-1α/CXC chemokine receptor 4 pathway, Mol Med Rep, 11, 4063, 10.3892/mmr.2015.3243 Li, 2020, Inhibition of microRNA-327 ameliorates ischemia/reperfusion injury-induced cardiomyocytes apoptosis through targeting apoptosis repressor with caspase recruitment domain, J Cell Physiol, 235, 3753, 10.1002/jcp.29270 Kavuri, 2011, Cellular FLICE-inhibitory protein (cFLIP) isoforms block CD95- and TRAIL death receptor-induced gene induction irrespective of processing of caspase-8 or cFLIP in the death-inducing signaling complex, J Biol Chem, 286, 16631, 10.1074/jbc.M110.148585 Irmler, 1997, Inhibition of death receptor signals by cellular FLIP, Nature, 388, 190, 10.1038/40657 Nakano, 2017, Cellular FLICE-inhibitory protein regulates tissue homeostasis, Curr Top Microbiol Immunol, 403, 119 French, 2015, Cytoplasmic levels of cFLIP determine a broad susceptibility of breast cancer stem/progenitor-like cells to TRAIL, Mol Cancer, 14, 209, 10.1186/s12943-015-0478-y Noh, 2012, CHOP down-regulates cFLIP(L) expression by promoting ubiquitin/proteasome-mediated cFLIP(L) degradation, J Cell Biochem, 113, 3692, 10.1002/jcb.24242 He, 2013, A role for c-FLIP(L) in the regulation of apoptosis, autophagy, and necroptosis in T lymphocytes, Cell Death Differ, 20, 188, 10.1038/cdd.2012.148 Stein, 2007, The late phase of ischemic preconditioning induces a prosurvival genetic program that results in marked attenuation of apoptosis, J Mol Cell Cardiol, 42, 1075, 10.1016/j.yjmcc.2007.03.908 Fricker, 2010, Model-based dissection of CD95 signaling dynamics reveals both a pro- and antiapoptotic role of c-FLIPL, J Cell Biol, 190, 377, 10.1083/jcb.201002060 Wang, 2018, Inflammation, autophagy, and apoptosis after myocardial infarction, J Am Heart Assoc, 7, 10.1161/JAHA.117.008024 Whelan, 2010, Cell death in the pathogenesis of heart disease: mechanisms and significance, Annu Rev Physiol, 72, 19, 10.1146/annurev.physiol.010908.163111 Xia, 2016, Signaling pathways in cardiac myocyte apoptosis, BioMed Res Int, 2016, 9583268, 10.1155/2016/9583268 Teringova, 2017, Apoptosis in ischemic heart disease, J Transl Med, 15, 87, 10.1186/s12967-017-1191-y Bagnoli, 2010, Cellular FLICE-inhibitory protein (c-FLIP) signalling: a key regulator of receptor-mediated apoptosis in physiologic context and in cancer, Int J Biochem Cell Biol, 42, 210, 10.1016/j.biocel.2009.11.015 Tait, 2010, Mitochondria and cell death: outer membrane permeabilization and beyond, Nat Rev Mol Cell Biol, 11, 621, 10.1038/nrm2952 Takagi, 2007, The role of autophagy in mediating cell survival and death during ischemia and reperfusion in the heart, Antioxid Redox Signal, 9, 1373, 10.1089/ars.2007.1689 Lin, 2018, Molecular mechanisms of autophagy in cardiac ischemia/reperfusion injury (Review), Mol Med Rep, 18, 675 Valentim, 2006, Urocortin inhibits Beclin1-mediated autophagic cell death in cardiac myocytes exposed to ischaemia/reperfusion injury, J Mol Cell Cardiol, 40, 846, 10.1016/j.yjmcc.2006.03.428 Maejima, 2021, Regulation of autophagy by Beclin 1 in the heart, J Mol Cell Cardiol, 95, 19, 10.1016/j.yjmcc.2015.10.032 Chen, 2019, The crosstalk between autophagy and apoptosis was mediated by phosphorylation of Bcl-2 and beclin1 in benzene-induced hematotoxicity, Cell Death Dis, 10, 772, 10.1038/s41419-019-2004-4 Hirpara, 2020, Superoxide induced inhibition of death receptor signaling is mediated via induced expression of apoptosis inhibitory protein cFLIP, Redox Biol, 30, 101403, 10.1016/j.redox.2019.101403 Guo, 2016, Radioprotective 105 kDa protein attenuates ischemia/reperfusion-induced myocardial apoptosis and autophagy by inhibiting the activation of the TLR4/NF-κB signaling pathway in rats, Int J Mol Med, 38, 885, 10.3892/ijmm.2016.2686 Wei, 2014, NF-κB-mediated miR-30b regulation in cardiomyocytes cell death by targeting Bcl-2, Mol Cell Biochem, 387, 135, 10.1007/s11010-013-1878-1 Matsushita, 2000, Hypoxia-induced endothelial apoptosis through nuclear factor-kappaB (NF-kappaB)-mediated bcl-2 suppression: in vivo evidence of the importance of NF-kappaB in endothelial cell regulation, Circ Res, 86, 974, 10.1161/01.RES.86.9.974 Wang, 2019, CFLAR is a critical regulator of cerebral ischaemia-reperfusion injury through regulating inflammation and endoplasmic reticulum (ER) stress, Biomed Pharmacother, 117, 109155, 10.1016/j.biopha.2019.109155 Xiao, 2021, Cellular FLICE-inhibitory protein protects against cardiac remodelling after myocardial infarction, Basic Res Cardiol, 107, 239, 10.1007/s00395-011-0239-z Wang, 2017, Targeting CASP8 and FADD-like apoptosis regulator ameliorates nonalcoholic steatohepatitis in mice and nonhuman primates, Nat Med, 23, 439, 10.1038/nm.4290 Gates-Tanzer, 2018, Cellular FLIP long isoform (cFLIPL)-IKKα interactions inhibit IRF7 activation, representing a new cellular strategy to inhibit IFNα expression, J Biol Chem, 293, 1745, 10.1074/jbc.RA117.000541 Wallert, 2019, α-Tocopherol preserves cardiac function by reducing oxidative stress and inflammation in ischemia/reperfusion injury, Redox Biol, 26, 101292, 10.1016/j.redox.2019.101292