Cell surface Death Receptor signaling in normal and cancer cells

Kluck, 1997, Cytochrome c activation of CPP32-like proteolysis plays a critical role in a Xenopus cell-free apoptosis system, EMBO J., 16, 4639, 10.1093/emboj/16.15.4639

Kroemer, 2000, Mitochondrial control of cell death, Nat. Med., 6, 513, 10.1038/74994

Green, 1998, Mitochondria and apoptosis, Science, 281, 1309, 10.1126/science.281.5381.1309

Li, 1997, Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an apoptotic protease cascade, Cell, 91, 479, 10.1016/S0092-8674(00)80434-1

Hengartner, 2000, The biochemistry of apoptosis, Nature, 407, 770, 10.1038/35037710

Du, 2000, Smac, a mitochondrial protein that promotes cytochrome c-dependent caspase activation by eliminating IAP inhibition, Cell, 102, 33, 10.1016/S0092-8674(00)00008-8

Verhagen, 2000, Identification of DIABLO, a mammalian protein that promotes apoptosis by binding to and antagonizing IAP proteins, Cell, 102, 43, 10.1016/S0092-8674(00)00009-X

Daugas, 2000, Mitochondrio-nuclear translocation of AIF in apoptosis and necrosis, FASEB J., 14, 729, 10.1096/fasebj.14.5.729

Susin, 1999, Mitochondrial release of caspase-2 and -9 during the apoptotic process, J. Exp. Med., 189, 381, 10.1084/jem.189.2.381

Suzuki, 2001, A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death, Mol. Cell, 8, 613, 10.1016/S1097-2765(01)00341-0

Parrish, 2001, Mitochondrial endonuclease G is important for apoptosis in C. elegans, Nature, 412, 90, 10.1038/35083608

Li, 2001, Endonuclease G is an apoptotic DNase when released from mitochondria, Nature, 412, 95, 10.1038/35083620

El-Deiry, 1998, The p53 pathway and cancer therapy, Cancer J., 11, 229

Miyashita, 1995, Tumor suppressor p53 is a direct transcriptional activator of the human bax gene, Cell, 80, 293, 10.1016/0092-8674(95)90412-3

Knudson, 1995, Bax-deficient mice with lymphoid hyperplasia and male germ cell death, Science, 270, 96, 10.1126/science.270.5233.96

Oda, 2000, Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis, Science, 288, 1053, 10.1126/science.288.5468.1053

Polyak, 1997, A model for p53-induced apoptosis, Nature, 389, 300, 10.1038/38525

Attardi, 2000, PERP, an apoptosis-associated target of p53, is a novel member of the PMP-22/gas3 family, Genes Dev., 14, 704, 10.1101/gad.14.6.704

Buckbinder, 1995, Induction of the growth inhibitor IGF-binding protein 3 by p53, Nature, 377, 646, 10.1038/377646a0

Rich, 2000, Defying death after DNA damage, Nature, 407, 777, 10.1038/35037717

Soengas, 1999, Apaf-1 and caspase-9 in p53-dependent apoptosis and tumor inhibition, Science, 284, 156, 10.1126/science.284.5411.156

Owen-Schaub, 1995, Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression, Mol. Cell Biol., 15, 3032, 10.1128/MCB.15.6.3032

Wu, 2000, Killer/DR5, a novel DNA-damage inducible death receptor gene, links the p53-tumor suppressor to caspase activation and apoptotic death, Adv. Exp. Med. Biol., 465, 143, 10.1007/0-306-46817-4_13

Gross, 1999, Caspase cleaved BID targets mitochondria and is required for cytochrome c release, while BCL-XL prevents this release but not tumor necrosis factor-R1/Fas death, J. Biol. Chem., 274, 1156, 10.1074/jbc.274.2.1156

Muller, 1998, p53 activates the CD95 (APO-1/Fas) gene in response to DNA damage by anticancer drugs, J. Exp. Med., 188, 2033, 10.1084/jem.188.11.2033

Takimoto, 2000, Wild-type p53 transactivates the KILLER/DR5 gene through an intronic sequence-specific DNA-binding site, Oncogene, 19, 1735, 10.1038/sj.onc.1203489

Burns, 2001, Tissue specific expression of p53 target genes suggests a key role for KILLER/DR5 in p53-dependent apoptosis in vivo, Oncogene, 20, 4601, 10.1038/sj.onc.1204484

Locksley, 2001, The TNF and TNF receptor superfamilies: integrating mammalian biology, Cell, 104, 487, 10.1016/S0092-8674(01)00237-9

Hu, 2000, dFADD, a novel death domain-containing adapter protein for the Drosophila caspase DREDD, J. Biol. Chem., 275, 30761, 10.1074/jbc.C000341200

Beg, 1996, An essential role for NF-kappaB in preventing TNF-alpha-induced cell death, Science, 274, 782, 10.1126/science.274.5288.782

Van Antwerp, 1996, Suppression of TNF-alpha-induced apoptosis by NF-kappaB, Science, 274, 787, 10.1126/science.274.5288.787

Hsu, 1995, The TNF receptor 1-associated protein TRADD signals cell death and NF- kappa B activation, Cell, 81, 495, 10.1016/0092-8674(95)90070-5

Chinnaiyan, 1995, FADD, a novel death domain-containing protein, interacts with the death domain of Fas and initiates apoptosis, Cell, 81, 505, 10.1016/0092-8674(95)90071-3

Liu, 1996, Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappaB activation prevents cell death, Cell, 87, 565, 10.1016/S0092-8674(00)81375-6

Kelliher, 1998, The death domain kinase RIP mediates the TNF-induced NF-kappaB signal, Immunity, 8, 297, 10.1016/S1074-7613(00)80535-X

Yeh, 1997, Early lethality, functional NF-kappaB activation, and increased sensitivity to TNF-induced cell death in TRAF2-deficient mice, Immunity, 7, 715, 10.1016/S1074-7613(00)80391-X

Tartaglia, 1992, Two TNF receptors, Immunol. Today, 13, 151, 10.1016/0167-5699(92)90116-O

Schulze-Osthoff, 1998, Apoptosis signaling by death receptors, Eur. J. Biochem., 254, 439, 10.1046/j.1432-1327.1998.2540439.x

Nagata, 1997, Apoptosis by death factor, Cell, 88, 355, 10.1016/S0092-8674(00)81874-7

Korner, 1997, Distinct roles for lymphotoxin-alpha and tumor necrosis factor in organogenesis and spatial organization of lymphoid tissue, Eur. J. Immunol., 27, 2600, 10.1002/eji.1830271020

Pfeffer, 1993, Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection, Cell, 73, 457, 10.1016/0092-8674(93)90134-C

Erickson, 1994, Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice, Nature, 372, 560, 10.1038/372560a0

Ashkenazi, 1998, Death receptors: signaling and modulation, Science, 281, 1305, 10.1126/science.281.5381.1305

Nagata, 1999, Fas ligand-induced apoptosis, Annu. Rev. Genet., 33, 29, 10.1146/annurev.genet.33.1.29

Nagata, 1995, The Fas death factor, Science, 267, 1449, 10.1126/science.7533326

Zhou, 2001, CED-1 is a transmembrane receptor that mediates cell corpse engulfment in C. elegans, Cell, 104, 43, 10.1016/S0092-8674(01)00190-8

Pitti, 1998, Genomic amplification of a decoy receptor for Fas ligand in lung and colon cancer, Nature, 396, 699, 10.1038/25387

Liu, 1998, Candidate adaptor protein CED-6 promotes the engulfment of apoptotic cells in C. elegans, Cell, 93, 961, 10.1016/S0092-8674(00)81202-7

Gumienny, 2001, Ced-12/elmo, a novel member of the crkii/dock180/rac pathway, is required for phagocytosis and cell migration, Cell, 107, 27, 10.1016/S0092-8674(01)00520-7

Zhou, 1997, Cooperative functions of the reaper and head involution defective genes in the programmed cell death of Drosophila central nervous system midline cells, Proc. Natl. Acad. Sci. U.S.A., 94, 5131, 10.1073/pnas.94.10.5131

Hengartner, 1994, C. elegans cell survival gene ced-9 encodes a functional homolog of the mammalian proto-oncogene bcl-2, Cell, 76, 665, 10.1016/0092-8674(94)90506-1

Brodsky, 2000, Drosophila p53 binds a damage response element at the reaper locus, Cell, 101, 103, 10.1016/S0092-8674(00)80627-3

Zha, 2000, Posttranslational N-myristoylation of BID as a molecular switch for targeting mitochondria and apoptosis, Science, 290, 1761, 10.1126/science.290.5497.1761

Walczak, 2000, The CD95 (APO-1/Fas) and the TRAIL (APO-2L) apoptosis systems, Exp. Cell Res., 256, 58, 10.1006/excr.2000.4840

Jenkins, 2000, A membrane-bound Fas decoy receptor expressed by human thymocytes, J. Biol. Chem., 275, 7988, 10.1074/jbc.275.11.7988

Vercammen, 1998, Dual signaling of the Fas receptor: initiation of both apoptotic and necrotic cell death pathways, J. Exp. Med., 188, 919, 10.1084/jem.188.5.919

Matsumura, 2000, Necrotic death pathway in Fas receptor signaling, J. Cell Biol., 151, 1247, 10.1083/jcb.151.6.1247

Vercammen, 1998, Inhibition of caspases increases the sensitivity of L929 cells to necrosis mediated by tumor necrosis factor, J. Exp. Med., 187, 1477, 10.1084/jem.187.9.1477

Watanabe-Fukunaga, 1992, Lymphoproliferation disorder in mice explained by defects in Fas antigen that mediates apoptosis, Nature, 356, 314, 10.1038/356314a0

Takahashi, 1994, Generalized lymphoproliferative disease in mice, caused by a point mutation in the Fas ligand, Cell, 76, 969, 10.1016/0092-8674(94)90375-1

Krammer, 2000, CD95’s deadly mission in the immune system, Nature, 407, 789, 10.1038/35037728

Ogasawara, 1993, Lethal effect of the anti-Fas antibody in mice, Nature, 364, 806, 10.1038/364806a0

Wiley, 1995, Identification and characterization of a new member of the TNF family that induces apoptosis, Immunity, 3, 673, 10.1016/1074-7613(95)90057-8

Mongkolsapaya, 1999, Structure of the TRAIL-DR5 complex reveals mechanisms conferring specificity in apoptotic initiation, Nat. Struct. Biol., 6, 1048, 10.1038/14935

Kayagaki, 1999, Type I interferons (IFNs) regulate tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) expression on human T cells: a novel mechanism for the antitumor effects of type I IFNs, J. Exp. Med., 189, 1451, 10.1084/jem.189.9.1451

Fanger, 1999, Human dendritic cells mediate cellular apoptosis via tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), J. Exp. Med., 190, 1155, 10.1084/jem.190.8.1155

Griffith, 1999, Monocyte-mediated tumoricidal activity via the tumor necrosis factor-related cytokine, TRAIL, J. Exp. Med., 189, 1343, 10.1084/jem.189.8.1343

Kayagaki, 1999, Expression and function of TNF-related apoptosis-inducing ligand on murine activated NK cells, J. Immunol., 163, 1906, 10.4049/jimmunol.163.4.1906

Smyth, 2001, Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) contributes to interferon gamma-dependent natural killer cell protection from tumor metastasis, J. Exp. Med., 193, 661, 10.1084/jem.193.6.661

Pan, 1997, The receptor for the cytotoxic ligand TRAIL, Science, 276, 111, 10.1126/science.276.5309.111

Walczak, 1997, TRAIL-R2: a novel apoptosis-mediating receptor for TRAIL, EMBO J., 16, 5386, 10.1093/emboj/16.17.5386

Screaton, 1997, TRICK2, a new alternatively spliced receptor that transduces the cytotoxic signal from TRAIL, Curr. Biol., 7, 693, 10.1016/S0960-9822(06)00297-1

Pan, 1997, An antagonist decoy receptor and a death domain-containing receptor for TRAIL, Science, 277, 815, 10.1126/science.277.5327.815

Sheridan, 1997, Control of TRAIL-induced apoptosis by a family of signaling and decoy receptors, Science, 277, 818, 10.1126/science.277.5327.818

Wu, 1997, KILLER/DR5 is a DNA damage-inducible p53-regulated death receptor gene, Nat. Genet., 17, 141, 10.1038/ng1097-141

MacFarlane, 1997, Identification and molecular cloning of two novel receptors for the cytotoxic ligand TRAIL, J. Biol. Chem., 272, 25417, 10.1074/jbc.272.41.25417

Chaudhary, 1997, Death receptor 5, a new member of the TNFR family, and DR4 induce FADD-dependent apoptosis and activate the NF-kappaB pathway, Immunity, 7, 821, 10.1016/S1074-7613(00)80400-8

Sprick, 2000, FADD/MORT1 and caspase-8 are recruited to TRAIL receptors 1 and 2 and are essential for apoptosis mediated by TRAIL receptor 2, Immunity, 12, 599, 10.1016/S1074-7613(00)80211-3

Kischkel, 2000, Apo2L/TRAIL-dependent recruitment of endogenous FADD and caspase-8 to death receptors 4 and 5, Immunity, 12, 611, 10.1016/S1074-7613(00)80212-5

Kischkel, 2001, Death receptor recruitment of endogenous caspase-10 and apoptosis initiation in the absence of caspase-8, J. Biol. Chem., 276, 46639, 10.1074/jbc.M105102200

Wang, 2001, Caspase-10 is an initiator caspase in death receptor signaling, Proc. Natl. Acad. Sci. U.S.A., 98, 13884, 10.1073/pnas.241358198

Yamada, 1999, TRAIL causes cleavage of bid by caspase-8 and loss of mitochondrial membrane potential resulting in apoptosis in BJAB cells, Biochem. Biophys. Res. Commun., 265, 130, 10.1006/bbrc.1999.1641

Degli-Esposti, 1997, Cloning and characterization of TRAIL-R3, a novel member of the emerging TRAIL receptor family, J. Exp. Med., 186, 1165, 10.1084/jem.186.7.1165

Degli-Esposti, 1997, The novel receptor TRAIL-R4 induces NF-kappaB and protects against TRAIL-mediated apoptosis, yet retains an incomplete death domain, Immunity, 7, 813, 10.1016/S1074-7613(00)80399-4

Truneh, 2000, Temperature-sensitive differential affinity of TRAIL for its receptors. DR5 is the highest affinity receptor, J. Biol. Chem., 275, 23319, 10.1074/jbc.M910438199

Schneider, 1997, TRAIL receptors 1 (DR4) and 2 (DR5) signal FADD-dependent apoptosis and activate NF-kappaB, Immunity, 7, 831, 10.1016/S1074-7613(00)80401-X

Marsters, 1997, A novel receptor for Apo2L/TRAIL contains a truncated death domain, Curr. Biol., 7, 1003, 10.1016/S0960-9822(06)00422-2

Long, 2000, Stimulation of erythropoiesis by inhibiting a new hematopoietic death receptor in transgenic zebrafish, Nat. Cell Biol., 2, 549, 10.1038/35019592

Wu, 1999, Molecular cloning and functional analysis of the mouse homologue of the KILLER/DR5 tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor, Cancer Res., 59, 2770

Pan, 1998, TRUNDD, a new member of the TRAIL receptor family that antagonizes TRAIL signalling, FEBS Lett., 424, 41, 10.1016/S0014-5793(98)00135-5

Nicholson, 2000, From bench to clinic with apoptosis-based therapeutic agents, Nature, 407, 810, 10.1038/35037747

Kim, 2000, Molecular determinants of response to TRAIL in killing of normal and cancer cells, Clin. Cancer Res., 6, 335

Rieger, 1998, APO2 ligand: a novel lethal weapon against malignant glioma?, FEBS Lett., 427, 124, 10.1016/S0014-5793(98)00409-8

Zhang, 1999, Relation of TNF-related apoptosis-inducing ligand (TRAIL) receptor and FLICE-inhibitory protein expression to TRAIL-induced apoptosis of melanoma, Cancer Res., 59, 2747

Mitsiades, 2001, Ewing’s sarcoma family tumors are sensitive to tumor necrosis factor-related apoptosis-inducing ligand and express death receptor 4 and death receptor 5, Cancer Res., 61, 2704

Griffith, 1998, Intracellular regulation of TRAIL-induced apoptosis in human melanoma cells, J. Immunol., 161, 2833, 10.4049/jimmunol.161.6.2833

Zhang, 2001, Tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis of human melanoma is regulated by smac/DIABLO release from mitochondria, Cancer Res., 61, 7339

Chen, 2001, Constitutively active Akt is an important regulator of TRAIL sensitivity in prostate cancer, Oncogene, 20, 6073, 10.1038/sj.onc.1204736

Walczak, 1999, Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo, Nat. Med., 5, 157, 10.1038/5517

Nagane, 2000, Increased death receptor 5 expression by chemotherapeutic agents in human gliomas causes synergistic cytotoxicity with tumor necrosis factor-related apoptosis-inducing ligand in vitro and in vivo, Cancer Res., 60, 847

Kim, 2001, Enhanced TRAIL sensitivity by p53 overexpression in human cancer but not normal cell lines, Int. J. Oncol., 18, 241

Chinnaiyan, 2000, Combined effect of tumor necrosis factor-related apoptosis-inducing ligand and ionizing radiation in breast cancer therapy, Proc. Natl. Acad. Sci. U.S.A., 97, 1754, 10.1073/pnas.030545097

Takeda, 2001, Involvement of tumor necrosis factor-related apoptosis-inducing ligand in surveillance of tumor metastasis by liver natural killer cells, Nat. Med., 7, 94, 10.1038/83416

Zamai, 1998, Natural killer (NK) cell-mediated cytotoxicity: differential use of TRAIL and Fas ligand by immature and mature primary human NK cells, J. Exp. Med., 188, 2375, 10.1084/jem.188.12.2375

Thomas, 1998, TNF-related apoptosis-inducing ligand (TRAIL) induces apoptosis in Fas ligand-resistant melanoma cells and mediates CD4 T cell killing of target cells, J. Immunol., 161, 2195, 10.4049/jimmunol.161.5.2195

Liu, 2001, The involvement of TNF-alpha-related apoptosis-inducing ligand in the enhanced cytotoxicity of IFN-beta-stimulated human dendritic cells to tumor cells, J. Immunol., 166, 5407, 10.4049/jimmunol.166.9.5407

Hsu, 1996, TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways, Cell, 84, 299, 10.1016/S0092-8674(00)80984-8

Thome, 1997, Viral FLICE-inhibitory proteins (FLIPs) prevent apoptosis induced by death receptors, Nature, 386, 517, 10.1038/386517a0

Irmler, 1997, Inhibition of death receptor signals by cellular FLIP, Nature, 388, 190, 10.1038/40657

Adams, 1998, The Bcl-2 protein family: arbiters of cell survival, Science, 281, 1322, 10.1126/science.281.5381.1322

Wei, 2001, Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death, Science, 292, 727, 10.1126/science.1059108

Deveraux, 1999, IAP family proteins—suppressors of apoptosis, Genes Dev., 13, 239, 10.1101/gad.13.3.239

Roy, 1997, The c-IAP-1 and c-IAP-2 proteins are direct inhibitors of specific caspases, EMBO J., 16, 6914, 10.1093/emboj/16.23.6914

Bratton, 2001, Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes, EMBO J., 20, 998, 10.1093/emboj/20.5.998

Srinivasula, 2001, A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis, Nature, 410, 112, 10.1038/35065125

Beere, 2000, Heat-shock protein 70 inhibits apoptosis by preventing recruitment of procaspase-9 to the Apaf-1 apoptosome, Nat. Cell Biol., 2, 469, 10.1038/35019501

Saleh, 2000, Negative regulation of the Apaf-1 apoptosome by Hsp70, Nat. Cell Biol., 2, 476, 10.1038/35019510

Pandey, 2000, Negative regulation of cytochrome c-mediated oligomerization of Apaf-1 and activation of procaspase-9 by heat shock protein 90a, EMBO J., 19, 4310, 10.1093/emboj/19.16.4310

Bruey, 2000, Hsp27 negatively regulates cell death by interacting with cytochrome c, Nat. Cell Biol., 2, 645, 10.1038/35023595

Hahne, 1996, Melanoma cell expression of Fas(Apo-1/CD95) ligand: implications for tumor immune escape, Science, 274, 1363, 10.1126/science.274.5291.1363

Takakuwa, 2002, Frequent mutations of Fas gene in nasal NK/T cell lymphoma, Oncogene, 21, 4702, 10.1038/sj.onc.1205571

Takayama, 2002, Frequent Fas gene mutations in testicular germ cell tumors, Am. J. Pathol., 161, 635, 10.1016/S0002-9440(10)64219-8

Boldrini, 2002, Identification of Fas (APO-1/CD95) and p53 gene mutations in non-small cell lung cancer, Int. J. Oncol., 20, 155

Shin, 1999, Alterations of Fas (Apo-1/CD95) gene in cutaneous malignant melanoma, Am. J. Pathol., 154, 1785, 10.1016/S0002-9440(10)65434-X

Gronbaek, 1998, Somatic Fas mutations in non-Hodgkin’s lymphoma: association with extranodal disease and autoimmunity, Blood, 92, 3018, 10.1182/blood.V92.9.3018

Lee, 1999, Alterations of Fas (APO-1/CD95) gene in transitional cell carcinomas of urinary bladder, Cancer Res., 59, 3068

Lee, 1999, Alterations of Fas (Apo-1/CD95) gene in non-small cell lung cancer, Oncogene, 18, 3754, 10.1038/sj.onc.1202769

Ozoren, 2000, Homozygous deletion of the death receptor DR4 gene in a nasopharyngeal cancer cell line is associated with TRAIL resistance, Int. J. Oncol., 16, 917

Fisher, 2001, Nucleotide substitution in the ectodomain of trail receptor DR4 is associated with lung cancer and head and neck cancer, Clin. Cancer Res., 7, 1688

Pai, 1998, Rare loss-of-function mutation of a death receptor gene in head and neck cancer, Cancer Res., 58, 3513

Lee, 1999, Alterations of the DR5/TRAIL receptor 2 gene in non-small cell lung cancers, Cancer Res., 59, 5683

McDonald, 2001, Death domain mutagenesis of KILLER/DR5 reveals residues critical for apoptotic signaling, J. Biol. Chem., 276, 14939, 10.1074/jbc.M100399200

Park, 2001, Inactivating mutations of KILLER/DR5 gene in gastric cancers, Gastroenterology, 121, 1219, 10.1053/gast.2001.28663

Sheikh, 1999, The antiapoptotic decoy receptor TRID/TRAIL-R3 is a p53-regulated DNA damage-inducible gene that is overexpressed in primary tumors of the gastrointestinal tract, Oncogene, 18, 4153, 10.1038/sj.onc.1202763

van Noesel, 2002, Tumor-specific down-regulation of the tumor necrosis factor-related apoptosis-inducing ligand decoy receptors DcR1 and DcR2 is associated with dense promoter hypermethylation, Cancer Res., 62, 2157

Bullani, 2001, Selective expression of FLIP in malignant melanocytic skin lesions, J. Invest. Dermatol., 117, 360, 10.1046/j.0022-202x.2001.01418.x

Jo, 2000, Apoptosis induced in normal human hepatocytes by tumor necrosis factor-related apoptosis-inducing ligand, Nat. Med., 6, 564, 10.1038/75045

Ozoren, 2000, The caspase 9 inhibitor Z-LEHD-FMK protects human liver cells while permitting death of cancer cells exposed to tumor necrosis factor-related apoptosis-inducing ligand, Cancer Res., 60, 6259

Lawrence, 2001, Differential hepatocyte toxicity of recombinant Apo2L/TRAIL versions, Nat. Med., 7, 383, 10.1038/86397

L, 2002, Characterization of the in vivo function of TNF-alpha-related apoptosis-inducing ligand, TRAIL/Apo2L, using TRAIL/Apo2L gene-deficient mice, Eur. J. Immunol., 32, 2246, 10.1002/1521-4141(200208)32:8<2246::AID-IMMU2246>3.0.CO;2-6

Hyer, 2002, Down-regulation of c-FLIP sensitizes D$145 prostate cancer cells to fas-mediated apoptosis, Cancer Biol. Ther., 1, 405, 10.4161/cbt.1.4.15

Yang, 2002, The FLIP side of cancer cell death, Cancer Biol. Ther., 1, 411, 10.4161/cbt.1.4.16

Kelly, 2002, Doxorubicin pretreatment sensitizes prostate cancer cell lines to TRAIL induced apoptosis which correlates with loss of c-FLIP expression, Cancer Biol. Ther., 1, 520, 10.4161/cbt.1.5.169

Guo, 2002, The FLIP variation on the TRAIL DISC: doxorubicin conducts the swan song, Cancer Biol. Ther., 1, 528, 10.4161/cbt.1.5.170