Cell‐based aqueous two‐phase systems for therapeutics

Journal of Chemical Technology and Biotechnology - Tập 95 Số 1 - Trang 8-10 - 2020
Mirna González‐González1, Marco Rito‐Palomares1
1Escuela de Medicina y Ciencias de la Salud, Tecnologico de Monterrey, Monterrey, Mexico

Tóm tắt

AbstractCell‐based aqueous two‐phase system technologies present an emerging and promising translational tool for the development of next‐generation therapeutic applications. Advantages such as biocompatibility, scalability and ease of implementation confirm this possibility. The aim of this perspective article is to present a brief, process‐oriented analysis of cell‐based aqueous two‐phase system strategies for therapeutic purposes, highlighting their potential advantages and limitations. These strategies include regenerative therapies, high‐throughput screening platforms and clinical diagnostics. Special attention is given to the implementation of polyethylene glycol and dextran aqueous two‐phase systems in the culture, expansion and separation of cells to accomplish novel diagnostic and therapeutic tasks for the healthcare, biotechnology and pharmaceutical industries. © 2019 Society of Chemical Industry

Từ khóa


Tài liệu tham khảo

10.3109/07388551.2013.794125

10.1002/btpr.1875

10.1002/jmr.2374

10.1007/s10529-011-0727-0

10.1016/j.chroma.2016.08.025

10.1002/adma.200904271

10.1002/bit.23190

10.1002/adfm.201401302

10.1007/s12195-014-0349-4

10.1021/acs.molpharmaceut.6b00527

10.1021/acsbiomaterials.8b00904

10.1021/acsami.5b05757

Han C, 2015, Formation and manipulation of cell spheroids using a density adjusted PEG/DEX aqueous two phase system, Sci Rep, 5

Frampton JP, 2014, Aqueous two‐phase system patterning of detection antibody solutions for cross‐reaction‐free multiplex ELISA, Sci Rep, 4, 10.1038/srep04878

10.1142/S2339547814500150

10.1002/biot.201400271

Thông tin
Thông tin xuất bản

Journal of Chemical Technology and Biotechnology

Tập 95 Số 1

8-10

Thông tin tác giả