Celastrol induces ferroptosis in activated HSCs to ameliorate hepatic fibrosis via targeting peroxiredoxins and HO-1

Acta Pharmaceutica Sinica B - Tập 12 - Trang 2300-2314 - 2022
Piao Luo1,2, Dandan Liu1, Qian Zhang1, Fan Yang3,4, Yin-Kwan Wong1, Fei Xia1, Junzhe Zhang1, Jiayun Chen1, Ya Tian1, Chuanbin Yang3, Lingyun Dai3, Han-Ming Shen5, Jigang Wang1,2,3,4,6
1Artemisinin Research Center, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China
2Central People's Hospital of Zhanjiang, Zhanjiang 524037, China
3Department of Urology, the Second Clinical Medical College, Jinan University (Shenzhen People's Hospital), Shenzhen 518020, China
4Integrated Chinese and Western Medicine Postdoctoral Research Station, Jinan University, Guangzhou 510632, China
5Faculty of Health Sciences, University of Macau, Taipa, Macau 999078, China
6Guangdong Provincial Key Laboratory of New Drug Screening, School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China

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